NiHowdy > Drug Classes > Prostaglandin Analogs

Browse Medications by Drug Class: Prostaglandin Analogs

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Prostaglandin Analogs?

Prostaglandin analogs are medications that mimic the effects of naturally occurring prostaglandins in the body, acting on specific receptors to regulate physiological processes. These drugs are primarily used to manage conditions like glaucoma, ocular hypertension, and gastric ulcers, and to induce labor in obstetric care. A unique characteristic of prostaglandin analogs is their ability to target localized tissue receptors, making them highly effective in treating specific conditions with minimal systemic effects. NiHowdy ensures affordable access to these essential therapies, supporting patients in managing their conditions effectively.

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List of drugs in Prostaglandin Analogs

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Bimatoprost	Bimatoprost Information	Bimatoprost Pricing
Carboprost Tromethamine	Carboprost Tromethamine Information	Carboprost Tromethamine Pricing
Cytotec	Cytotec Information	Cytotec Pricing
Latanoprost	Latanoprost Information	Latanoprost Pricing
Latanoprost-Timolol Maleate	Latanoprost-Timolol Maleate Information	Latanoprost-Timolol Maleate Pricing
Latisse	Latisse Information	Latisse Pricing
Lumigan	Lumigan Information	Lumigan Pricing
miSOPROStol	miSOPROStol Information	miSOPROStol Pricing
Tafluprost (PF)	Tafluprost (PF) Information	Tafluprost (PF) Pricing
Travatan Z	Travatan Z Information	Travatan Z Pricing
Travoprost (BAK Free)	Travoprost (BAK Free) Information	Travoprost (BAK Free) Pricing
Vyzulta	Vyzulta Information	Vyzulta Pricing
Xalatan	Xalatan Information	Xalatan Pricing
Xelpros	Xelpros Information	Xelpros Pricing
Zioptan	Zioptan Information	Zioptan Pricing

Brief history about Prostaglandin Analogs?

The discovery of prostaglandins in the 1930s revolutionized the understanding of local hormones and their role in physiological processes. By the 1970s, synthetic prostaglandin analogs were developed to harness their therapeutic potential. Early examples included agents for inducing labor and managing gastric ulcers. The introduction of prostaglandin analogs for glaucoma in the 1990s marked a significant advancement, providing a highly effective, first-line treatment option for reducing intraocular pressure. NiHowdy simplifies access to these therapies, ensuring affordability for patients managing a wide range of conditions.

How do Prostaglandin Analogs work?

Prostaglandin analogs work by binding to specific prostaglandin receptors in target tissues, triggering localized effects. For example, in glaucoma, these drugs act on the FP prostaglandin receptor to increase the outflow of aqueous humor from the eye, reducing intraocular pressure. In labor induction, they stimulate uterine contractions by interacting with receptors in the uterine muscle. Similarly, in gastric ulcer prevention, they reduce stomach acid secretion and enhance the production of protective mucus. NiHowdy ensures patients can access these targeted and effective therapies affordably, helping them achieve better health outcomes.

What are Prostaglandin Analogs used to treat?

Glaucoma

Prostaglandin analogs like latanoprost, bimatoprost, and travoprost are the first-line treatment for glaucoma and ocular hypertension. These medications lower intraocular pressure by increasing the outflow of aqueous humor through the uveoscleral pathway. This reduction in pressure helps prevent optic nerve damage and vision loss, making these drugs essential for managing chronic eye conditions.

Ulcers

Misoprostol, a prostaglandin analog, is used to prevent and treat gastric ulcers, particularly in patients taking long-term nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing stomach acid secretion and increasing the production of protective mucus and bicarbonate, creating a barrier against gastric damage.

Induction of Labor

Prostaglandin analogs like dinoprostone and misoprostol are used to induce labor by softening the cervix (cervical ripening) and stimulating uterine contractions. These medications are critical in obstetric care for managing prolonged pregnancies or medical conditions requiring early delivery.

Pulmonary Arterial Hypertension (PAH)

In PAH, prostaglandin analogs such as epoprostenol and treprostinil dilate blood vessels in the lungs and inhibit platelet aggregation, reducing pulmonary vascular resistance. This improves blood flow and oxygenation, alleviating symptoms like shortness of breath and fatigue.

Who should consider Prostaglandin Analogs medications?

Adults

Adults with conditions like glaucoma, gastric ulcers, or PAH are ideal candidates for prostaglandin analogs. These medications provide targeted therapeutic effects with minimal systemic risks. For example, individuals with high intraocular pressure benefit from eye drops like latanoprost, while those at risk of NSAID-induced ulcers find relief with misoprostol. Healthcare providers tailor treatment plans to individual needs, ensuring safety and efficacy.

Children

Prostaglandin analogs are used cautiously in pediatric populations, primarily for managing congenital glaucoma or PAH. Doses are carefully calculated based on the child's age, weight, and specific condition. Close monitoring by a pediatric specialist ensures safe and effective treatment.

Seniors

Seniors with chronic conditions like glaucoma or PAH benefit significantly from prostaglandin analogs. These medications help manage disease progression and improve quality of life. Healthcare providers consider age-related changes in metabolism and co-existing health conditions to minimize side effects and optimize therapy.

Are Prostaglandin Analogs safe?

Prostaglandin analogs are generally safe when used as prescribed. Common side effects include redness or irritation at the application site (e.g., eye drops) and mild gastrointestinal discomfort (e.g., oral formulations). Rare but serious risks include uterine rupture during labor induction or systemic hypotension in PAH treatments. Regular monitoring and adherence to prescribed regimens ensure safe and effective use. NiHowdy provides affordable access to these therapies, supporting patients in achieving better health outcomes.

Can I take Prostaglandin Analogs during pregnancy?

The safety of prostaglandin analogs during pregnancy depends on the specific medication and its intended use. For example, misoprostol is contraindicated for gastric ulcers during pregnancy but is used under strict medical supervision for labor induction. Pregnant individuals should consult their healthcare provider for guidance on safe and effective treatment options.

Are Prostaglandin Analogs safe to take while lactating?

The safety of prostaglandin analogs during breastfeeding varies by medication. For instance, latanoprost eye drops have minimal systemic absorption and are considered safe, while other formulations like misoprostol may require caution. Patients should consult their healthcare provider to evaluate the risks and benefits.

Are Prostaglandin Analogs controlled substances?

Prostaglandin analogs are not classified as controlled substances. They are widely available by prescription for managing various conditions, including glaucoma, gastric ulcers, and PAH. NiHowdy simplifies access to these essential medications, ensuring affordability and convenience for patients.

Side effects of Prostaglandin Analogs?

Prostaglandin analogs are effective medications but may cause side effects depending on the formulation and route of administration. Common side effects of eye drop formulations include redness, irritation, and darkening of the iris or eyelid skin. These effects are usually mild and resolve over time or with continued use. Patients using oral formulations like misoprostol may experience gastrointestinal symptoms, including nausea, diarrhea, or abdominal cramping, which can often be managed with dose adjustments or supportive care. Less common side effects include systemic effects such as headache, dizziness, or transient changes in blood pressure. These symptoms are typically mild and do not require discontinuation of therapy unless they persist or worsen. Rare but serious side effects vary by medication. For example, uterine rupture or excessive uterine contractions may occur during labor induction with misoprostol or dinoprostone. In PAH treatments, systemic hypotension or bleeding disorders are potential risks. Patients experiencing severe symptoms should seek immediate medical attention. To ensure safe use, healthcare providers monitor patients regularly and tailor therapy to individual needs. Adherence to prescribed doses and timely communication of side effects help optimize treatment outcomes and minimize risks.

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Cost considerations and insurance coverage for Prostaglandin Analogs

The cost of prostaglandin analogs varies depending on the specific medication and its intended use. Generic formulations like latanoprost are affordable, while branded medications for PAH, such as treprostinil, may be more expensive. Most insurance plans cover these drugs for approved conditions. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure these treatments remain accessible and cost-effective.

How do I get rebates on Prostaglandin Analogs?

NiHowdy's Bitcoin rebate program for prostaglandin analogs offers patients a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing chronic conditions both affordable and rewarding, improving access to life-changing treatments while building long-term value.