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Tafluprost (PF)
Tafluprost (PF) is a prostaglandin analog used to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Reducing high eye pressure is important in preventing blindness or damage to the optic nerve. The "PF" designation stands for preservative-free, meaning that the formulation does not contain preservatives, making it suitable for patients with sensitivity to preservatives often found in eye drops.
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Frequently Asked Questions
How long does it take for tafluprost to start working?
Tafluprost begins to lower intraocular pressure within 2 to 4 hours of administration, but maximum effects may take 12 hours or longer. Regular use is necessary to maintain control over intraocular pressure.
Can tafluprost permanently change my eye color?
Yes, tafluprost can cause permanent darkening of the iris in some patients, especially those with lighter eye colors. This effect is generally harmless but irreversible.
How should I store tafluprost?
Store unopened vials in the refrigerator. Once opened, the individual vial can be stored at room temperature but should be used immediately and discarded after each use to prevent contamination.
Can I use tafluprost with contact lenses?
You should remove your contact lenses before applying tafluprost and wait at least 15 minutes before reinserting them, as the preservative-free solution can still be absorbed by the lenses.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember unless it is close to the time of your next dose. Do not double up doses to make up for a missed one.
Comprehensive Drug Guide
How Does Tafluprost (PF) Work?
Tafluprost works by mimicking the effects of prostaglandin F2-alpha, a naturally occurring substance in the body that helps regulate the outflow of aqueous humor (fluid) from the eye. By increasing the drainage of this fluid through the uveoscleral pathway, tafluprost reduces intraocular pressure, which helps protect the optic nerve from damage.
Common Dosages
- 0.0015% ophthalmic solution (preservative-free), typically supplied in single-use vials.
Typical Dosing
- For glaucoma or ocular hypertension: The typical dose is one drop in the affected eye(s) once daily in the evening. It is important not to administer more than once daily, as frequent dosing can reduce the effectiveness of the medication.
Typical Dosing
FDA Approved Indications
- Reducing elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
Who Shouldn't Take Tafluprost (PF)?
- Hypersensitivity to tafluprost or any components of the formulation.
Advice From The Pharmacist
- Administer tafluprost in the evening for optimal results. Ensure you wash your hands before using the eye drops.
- Each vial of the preservative-free formulation is intended for single use only. Once opened, discard the vial after use to prevent contamination.
- After applying the drops, close your eyes for 1-2 minutes and gently press your finger on the inner corner of your eye to prevent the solution from draining through the tear duct.
- Remove contact lenses before applying tafluprost, and wait at least 15 minutes before reinserting them, as the solution can be absorbed by the lenses.
- Report any changes in vision, eye color, or eyelash growth to your doctor.
Side Effects of Tafluprost (PF)
Common Side Effects
- Eye redness
- Itching or discomfort in the eye
- Increased pigmentation of the iris (the colored part of the eye)
- Eyelash growth or darkening
Uncommon/Severe Side Effects
- Blurred vision
- Eye infection or severe eye irritation
- Swelling of the retina (macular edema)
- Changes in vision
Risks and Warnings of Tafluprost (PF)
- Iris Pigmentation: Tafluprost can cause a permanent change in the color of the iris (usually darkening), especially in patients with light-colored eyes (blue, green, or hazel). This change is usually slow and may not be noticeable for months or years.
- Eyelash Changes: Tafluprost can cause increased eyelash growth, thickness, or darkening. These changes are generally reversible after discontinuation.
- Macular Edema: In rare cases, tafluprost may cause swelling of the retina, especially in patients with a history of retinal conditions. Report any sudden vision changes to your doctor.
Interactions with Tafluprost (PF)
Common Drug Interactions
Tafluprost is an ophthalmic medication with minimal systemic absorption, so drug interactions are uncommon. However, if you are using multiple types of eye drops, wait at least 5 minutes between applying tafluprost and other eye medications.
Alternatives to Tafluprost (PF)
- Latanoprost (Xalatan): Another prostaglandin analog used to reduce intraocular pressure.
- Travoprost (Travatan Z): A prostaglandin analog that may be used as an alternative, particularly in patients sensitive to preservatives.
- Bimatoprost (Lumigan): Another prostaglandin analog that can be used for lowering intraocular pressure.
- Timolol: A beta-blocker eye drop that is commonly used as an alternative or adjunct therapy to prostaglandin analogs.
