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Latanoprost-Timolol Maleate
Latanoprost-timolol maleate is a combination eye drop medication used to treat intraocular pressure in patients with open-angle glaucoma and ocular hypertension. Latanoprost is a prostaglandin analog that increases the outflow of aqueous humor, while timolol is a non-selective beta-blocker that decreases aqueous humor production.
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Frequently Asked Questions
How long does it take for latanoprost-timolol maleate to start working?
Latanoprost-timolol typically starts to lower intraocular pressure within 1 to 2 hours after administration, with peak effects around 6 to 8 hours.
Can I take latanoprost-timolol maleate with other medications?
Always consult your healthcare provider before combining latanoprost-timolol with other medications, especially other eye drops.
What should I do if I miss a dose of latanoprost-timolol maleate?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use latanoprost-timolol maleate during pregnancy?
Latanoprost-timolol should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can latanoprost-timolol maleate cause weight gain?
Weight gain is not commonly associated with latanoprost-timolol. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Latanoprost-Timolol Maleate Work?
- Latanoprost: Increases the outflow of aqueous humor through the uveoscleral pathway, thereby lowering intraocular pressure.
- Timolol: Decreases the production of aqueous humor by the ciliary body, leading to reduced intraocular pressure.
Common Dosages
- Ophthalmic solution: Common concentration is 0.005% latanoprost and 0.5% timolol.
Typical Dosing
- The usual dosage is one drop in the affected eye(s) once daily, typically in the evening, as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
Reduction of intraocular pressure in patients with open-angle glaucoma and ocular hypertension.
Who Shouldn't Take Latanoprost-Timolol Maleate?
- Known hypersensitivity to latanoprost, timolol, or any components of the formulation
- Asthma or severe chronic obstructive pulmonary disease (COPD)
- Severe bradycardia or heart block without a functioning pacemaker
Advice From The Pharmacist
- Patients should be advised on the proper technique for administering eye drops to ensure effective delivery of the medication.
- Discuss the importance of adhering to the dosing schedule and regular follow-up appointments to monitor intraocular pressure.
- Inform patients about potential side effects and encourage them to report any severe respiratory or cardiac symptoms.
Side Effects of Latanoprost-Timolol Maleate
Common Side Effects
- Eye irritation or burning upon instillation
- Dry eyes
- Increased pigmentation of the iris
- Blurred vision
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Respiratory difficulties or bronchospasm
Risks and Warnings of Latanoprost-Timolol Maleate
- Respiratory Risks: Use caution in patients with a history of respiratory conditions, as beta-blockers can exacerbate bronchospasm.
- Cardiovascular Monitoring: Patients with heart conditions should be monitored for changes in heart rate and rhythm.
Interactions with Latanoprost-Timolol Maleate
Common Drug Interactions
- Other Ophthalmic Medications: Allow at least 5 minutes between the administration of latanoprost-timolol and other eye drops to avoid dilution.
- Systemic Beta-Blockers: May increase the risk of systemic side effects; monitor patients closely.
Alternatives to Latanoprost-Timolol Maleate
- Other Combination Eye Drops: Such as dorzolamide-timolol or brimonidine-timolol for managing intraocular pressure.
- Prostaglandin Analogs Alone: Such as latanoprost or travoprost for glaucoma treatment.
