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Vyzulta
Vyzulta (generic name: latanoprostene bunod) is an ophthalmic solution used to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It is a prostaglandin analog, designed to reduce eye pressure by increasing the outflow of aqueous humor (the fluid inside the eye), helping to prevent damage to the optic nerve and reducing the risk of vision loss.
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Frequently Asked Questions
How long does it take for Vyzulta to start lowering eye pressure?
Vyzulta typically begins to reduce intraocular pressure within 2 to 4 hours after administration, with maximum effect seen in about 12 hours.
Can Vyzulta change the color of my eyes?
Yes, Vyzulta may cause gradual darkening of the iris, especially in people with light-colored eyes. This change is typically permanent.
What should I do if I miss a dose of Vyzulta?
If you miss a dose, apply it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Can I use Vyzulta with other eye drops?
Yes, Vyzulta can be used in combination with other glaucoma medications. Wait at least 5 minutes between applying Vyzulta and other eye drops.
How should I store Vyzulta?
Before opening, store Vyzulta in the refrigerator. Once opened, it can be stored at room temperature for up to 8 weeks. Keep the bottle tightly closed and away from direct light.
Comprehensive Drug Guide
How Does Vyzulta Work?
Vyzulta works by targeting two pathways to increase the outflow of aqueous humor. It metabolizes into latanoprost acid, which increases uveoscleral outflow, and butanediol mononitrate, which releases nitric oxide to enhance the trabecular meshwork outflow. This dual mechanism helps lower intraocular pressure effectively, reducing the risk of optic nerve damage and potential vision loss in patients with glaucoma or ocular hypertension.
Common Dosages
- Vyzulta is available as a 0.024% ophthalmic solution in 2.5 mL or 5 mL bottles. The typical dose is one drop in the affected eye(s) once daily in the evening.
Typical Dosing
- Adults: The standard dose is one drop in the affected eye(s) once daily, preferably in the evening. Do not exceed once-daily dosing, as more frequent administration may reduce the effectiveness of the medication.
Typical Dosing
FDA Approved Indications
- Reduction of elevated intraocular pressure in patients with open-angle glaucoma
- Management of ocular hypertension
Who Shouldn't Take Vyzulta?
- Known hypersensitivity to latanoprostene bunod, latanoprost, or any other components of the formulation.
- Active ocular infections, such as viral or bacterial eye infections, without consulting a healthcare provider.
Advice From The Pharmacist
- Apply one drop of Vyzulta to the affected eye(s) in the evening. If using other eye drops, wait at least 5 minutes between applications.
- Avoid touching the dropper tip to your eye or any other surface to prevent contamination.
- Remove contact lenses before applying Vyzulta, and wait at least 15 minutes before reinserting them.
- Store Vyzulta in the refrigerator before opening, but once opened, it can be kept at room temperature for up to 8 weeks.
Side Effects of Vyzulta
Common Side Effects
- Eye redness (hyperemia)
- Eye discomfort or irritation
- Blurred vision
- Increased pigmentation of the iris (darkening)
Uncommon/Severe Side Effects
- Changes in eyelashes, including increased length, thickness, and number of lashes
- Macular edema (swelling in the retina)
- Eye infection (discharge, pain, or swelling)
Risks and Warnings of Vyzulta
- Iris Pigmentation: Vyzulta may cause a gradual increase in brown pigmentation of the iris, which can be permanent. This change is cosmetic and does not affect vision.
- Eyelash Changes: Vyzulta can cause changes in the appearance of eyelashes, including growth in length, thickness, and number of lashes, which is reversible upon discontinuation of the medication.
- Macular Edema: Patients with risk factors for macular edema should be monitored closely while using Vyzulta.
Interactions with Vyzulta
Common Drug Interactions
- Other glaucoma medications: Vyzulta can be used with other glaucoma medications, but consult your healthcare provider to determine the best treatment plan.
- Contact lenses: Soft contact lenses should not be worn immediately after applying Vyzulta due to the potential for absorption of preservatives by the lenses.
Alternatives to Vyzulta
- Xalatan (latanoprost): A prostaglandin analog that increases aqueous outflow to reduce IOP.
- Lumigan (bimatoprost): Another prostaglandin analog used to lower intraocular pressure in patients with glaucoma.
- Timoptic (timolol): A beta-blocker used to lower intraocular pressure by reducing aqueous humor production.
- Travatan Z (travoprost): A prostaglandin analog similar to Vyzulta, used for the treatment of glaucoma.
