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miSOPROStol
Misoprostol is a medication used to prevent stomach ulcers in patients who take nonsteroidal antiinflammatory drugs (NSAIDs). It is also used in combination with another drug to end an early pregnancy. Some common side effects include nausea, vomiting, and indigestion, but your doctor will usually monitor these and make sure the benefits exceed any potential discomfort.
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Frequently Asked Questions
Can I take Misoprostol with food?
Yes, it is often recommended that misoprostol be taken with food to reduce stomach discomfort.
Can Misoprostol be used to induce labor?
Yes, but it should be under the supervision of a healthcare provider because it can cause intense contractions.
Can Misoprostol cause diarrhea?
Yes, one of the most common side effects of misoprostol is diarrhea.
Does Misoprostol cause bleeding?
Yes, especially when used for the termination of an early pregnancy.
Comprehensive Drug Guide
How Does miSOPROStol Work?
Misoprostol is a synthetic prostaglandin E1 analog that increases the secretion of protective mucus by activating prostaglandin EP3 receptors on gastrointestinal epithelial cells. Abortive therapies induce uterine contractions to facilitate the expulsion of uterine contents.
What is miSOPROStol Used For?
FDA indications: Preventive treatment of nonsteroidal antiinflammatory drug (NSAID)?induced gastric ulcers and as a component of a drug regimen for medical abortion.
Offlabel uses: It?s also utilized as a laborinducing agent or in the treatment of severe postpartum hemorrhage.
Common Dosages
Tablets: 100mcg, 200mcg
Typical Dosing
FDA Approved Indications
- For gastric ulcer prevention due to NSAIDs: 200mcg 34 times a day
Off-Label Uses
- Early pregnancy termination: 800mcg buccally every 3 to 12 hours, not exceeding 3 doses within 24 hours.
Who Shouldn't Take miSOPROStol?
- Individuals with an allergy to misoprostol or any other component of the medication
- Pregnant individuals who are not intending to terminate the pregnancy, as misoprostol can cause birth defects, premature birth, or uterine rupture.
- Patients with conditions where the induction of contractions is a concern (like during pregnancy).
- Individuals with a history of cardiovascular disease, hypertension, or hepatic or renal disease.
Advice From The Pharmacist
- Misoprostol should be taken with meals to reduce the risk of diarrhea.
- If you're a woman of childbearing potential, you should take a pregnancy test to confirm that you're not pregnant before starting misoprostol.
- If you're pregnant and you take misoprostol, you must be under the supervision of a healthcare provider who is willing and able to manage any potential complications of use in pregnancy.
- Stay hydrated and watch for signs of dehydration, particularly if diarrhea is a problem.
- Avoid alcohol and tobacco while taking misoprostol to reduce the risk of stomach complications.
Side Effects of miSOPROStol
Common Side Effects
- Diarrhea
- Abdominal pain
- Nausea
- Vomiting
- Gas
- Indigestion
Uncommon/Severe Side Effects
- Menstrual changes (such as irregular periods, and spotting) may occur in women.
- Chest pain, rapid heartbeat, or feelings of faintness.
Risks and Warnings of miSOPROStol
- Misoprostol has the potential to cause complications in people with a history of cardiovascular disease, hypertension, or hepatic or renal disease.
- Misoprostol should not be used in pregnancy unless being utilized for legal termination of an early pregnancy.
- It's important to get regular checkups and follow your doctor's instructions closely while taking misoprostol.
Interactions with miSOPROStol
Common Drug Interactions
- Antacids: may affect how misoprostol works.
- Magnesiumcontaining antacids: taking misoprostol with these medications may increase the risk of diarrhea.
Alternatives to miSOPROStol
- Omeprazole
- Ranitidine
- Famotidine
- Pantoprazole
- Cimetidine
- Sucralfate
