Browse Medications by Drug Class: Estrogen Replacement Therapies

Written by Amar Lunagaria
Pharm.D • NiHowdy Founder

Reviewed by James Wong
Pharm.D • NiHowdy Founder
Published Jan 15, 2025

What are Estrogen Replacement Therapies?
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List of drugs in Estrogen Replacement Therapies
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Brief history about Estrogen Replacement Therapies?
How do Estrogen Replacement Therapies work?
What are Estrogen Replacement Therapies used to treat?
Menopause Symptoms
ERT is the gold standard for treating menopause-related symptoms such as hot flashes, night sweats, and vaginal dryness. By replenishing estrogen levels, it alleviates these disruptive symptoms, improving quality of life. Localized formulations, such as vaginal creams or rings, specifically target genitourinary symptoms, while systemic ERT addresses a broader range of menopausal complaints.
Osteoporosis Prevention
In postmenopausal individuals, ERT plays a crucial role in preventing bone density loss and reducing the risk of osteoporosis. By inhibiting bone resorption, estrogen supports bone health and reduces the likelihood of fractures, particularly in the spine and hips. ERT is often part of a comprehensive bone health strategy that includes calcium and vitamin D supplementation.
Hypogonadism
ERT is used to treat estrogen deficiency in individuals with hypogonadism or primary ovarian insufficiency, conditions characterized by impaired ovarian function. By restoring estrogen levels, ERT supports normal development of secondary sexual characteristics, menstrual regulation, and bone health.
Who should consider Estrogen Replacement Therapies medications?
Adults
Adults experiencing menopause, surgical menopause, or conditions like primary ovarian insufficiency are prime candidates for ERT. These medications alleviate estrogen deficiency symptoms, improve bone health, and reduce long-term health risks. Healthcare providers carefully assess individual health needs to tailor ERT regimens, balancing benefits with potential risks.
Children
In rare cases, ERT may be used in pediatric populations with delayed puberty or estrogen deficiency due to hypogonadism. Treatment is carefully monitored to support normal pubertal development and reduce long-term complications like bone density loss. Doses are adjusted based on developmental needs.
Seniors
Seniors, particularly postmenopausal individuals, may use ERT to manage long-term health risks like osteoporosis and cardiovascular disease. Age-related changes in health and metabolism necessitate careful consideration of the risks, such as venous thromboembolism or stroke, and the benefits of ERT in this population.
Are Estrogen Replacement Therapies safe?
Can I take Estrogen Replacement Therapies during pregnancy?
Are Estrogen Replacement Therapies safe to take while lactating?
Are Estrogen Replacement Therapies controlled substances?
Side effects of Estrogen Replacement Therapies?
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