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Climara
Climara is a transdermal patch containing estradiol, a form of estrogen hormone used for hormone replacement therapy (HRT) in postmenopausal women. It is commonly prescribed to treat symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness, as well as to prevent osteoporosis in women at high risk. Climara provides continuous hormone delivery through the skin and is designed for once-weekly application, offering a convenient treatment option for managing menopausal symptoms.
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Frequently Asked Questions
How long does it take for Climara to start working?
Climara may begin to relieve menopausal symptoms within a few days, but it may take several weeks to experience the full benefit. The relief of symptoms can vary from person to person.
Can I use Climara if I still have my uterus?
Yes, but women with an intact uterus are typically prescribed a progestin along with estrogen therapy to reduce the risk of endometrial cancer. Consult your healthcare provider for the appropriate therapy.
What should I do if my Climara patch falls off?
If the patch falls off, try reapplying it to a different area of your lower abdomen or buttocks. If it does not adhere properly, apply a new patch and continue with your regular patch-changing schedule.
Can I shower or swim while wearing Climara?
Yes, you can shower, bathe, and swim while wearing the Climara patch. However, avoid rubbing or scrubbing the area where the patch is applied, as this may cause it to come off.
Is Climara safe for long-term use?
Long-term use of hormone replacement therapy, including Climara, carries certain risks, such as an increased risk of breast cancer, heart disease, and stroke. Your healthcare provider will regularly evaluate the benefits and risks of continuing therapy, especially if you are using it for an extended period.
Comprehensive Drug Guide
How Does Climara Work?
Climara works by providing a steady release of estradiol, a natural form of estrogen, through the skin and into the bloodstream. Estrogen levels drop during menopause, which can lead to uncomfortable symptoms. By restoring estrogen levels, Climara helps alleviate symptoms such as hot flashes, night sweats, and vaginal dryness. In addition, it helps maintain bone density and reduce the risk of osteoporosis by slowing the breakdown of bone tissue.
Common Dosages
- Transdermal Patch: 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day
Typical Dosing
- For menopausal symptoms: Apply one patch to the lower abdomen or buttocks once a week. The strength of the patch and duration of use will depend on the severity of symptoms and individual treatment needs.
- For osteoporosis prevention: Apply one patch once a week. Your healthcare provider will determine the appropriate dose based on your risk factors and bone density.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vasomotor symptoms (hot flashes) due to menopause
- Treatment of vaginal and vulvar atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Who Shouldn't Take Climara?
- Known or suspected breast cancer or estrogen-dependent neoplasia
- Undiagnosed abnormal genital bleeding
- Active or history of deep vein thrombosis (DVT), pulmonary embolism, or arterial thromboembolic diseases (e.g., stroke, heart attack)
- Liver dysfunction or disease
- Pregnancy
Advice From The Pharmacist
- Apply the patch to clean, dry, and intact skin on the lower abdomen or buttocks. Avoid placing it on or near the breasts.
- Do not apply the patch to areas where it may be exposed to tight clothing or friction, as this may cause the patch to come off.
- Rotate the application site each week to avoid skin irritation.
- If the patch falls off, reapply it or use a new patch in a different location. Continue following your regular patch-changing schedule.
- Avoid exposing the patch to direct sunlight or excessive heat, as this may affect the release of the hormone.
Side Effects of Climara
Common Side Effects
- Skin irritation at the application site (redness, itching)
- Headache
- Breast tenderness
- Nausea
- Abdominal pain
- Bloating
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- Increased risk of breast or endometrial cancer
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Climara
- Cardiovascular Risks: Estrogen therapy may increase the risk of blood clots, stroke, and heart attack, particularly in women with pre-existing risk factors such as high blood pressure, high cholesterol, or a history of smoking.
- Cancer Risks: Long-term use of estrogen without progestin in women with an intact uterus may increase the risk of endometrial cancer. Women should discuss the risks of estrogen therapy with their healthcare provider, particularly if they have a family history of cancer.
- Gallbladder Disease: Estrogen use has been associated with an increased risk of gallbladder disease. Women with a history of gallbladder issues should inform their healthcare provider before starting Climara.
Interactions with Climara
Common Drug Interactions
- Thyroid Hormones: Estrogens may affect the levels of thyroid-binding globulin, potentially altering the dose requirements for thyroid hormone replacement therapy.
- Blood Thinners (Warfarin): Estrogen therapy may reduce the effectiveness of anticoagulants, leading to an increased risk of blood clots.
- Corticosteroids: Concomitant use of corticosteroids and estrogen therapy may lead to increased effects of corticosteroids.
Alternatives to Climara
- Estradiol Oral Tablets: Estrogen therapy in oral form to manage menopausal symptoms and prevent osteoporosis.
- Estrogen-Progestin Combination (Prempro): An alternative hormone replacement therapy that combines estrogen with progestin to reduce the risk of endometrial cancer in women with an intact uterus.
- Raloxifene (Evista): A selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women without the use of traditional estrogen therapy.
