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Evista
Evista (raloxifene) is a selective estrogen receptor modulator (SERM) used primarily to treat and prevent osteoporosis in postmenopausal women. It is also indicated to reduce the risk of invasive breast cancer in postmenopausal women at high risk or those with osteoporosis. Evista mimics estrogen's positive effects on bone density while blocking its effects on breast and uterine tissues.
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Frequently Asked Questions
Can Evista prevent fractures?
Yes, Evista can help prevent fractures by increasing bone density in postmenopausal women with osteoporosis.
Does Evista reduce the risk of breast cancer?
Yes, Evista reduces the risk of invasive breast cancer in postmenopausal women with osteoporosis or those at high risk of breast cancer.
Can Evista cause weight gain?
Weight gain is not a common side effect of Evista, but some women may experience changes in weight while on the medication.
How long should I take Evista?
Your doctor will determine the duration of treatment based on your condition and risk factors. Long-term use may be needed to maintain bone health and reduce cancer risk.
Can Evista be used during pregnancy?
No, Evista should not be used during pregnancy, as it can cause harm to the fetus.
Comprehensive Drug Guide
How Does Evista Work?
Evista works by binding to estrogen receptors, selectively activating or blocking the effects of estrogen in different tissues. It helps maintain bone density by acting as an estrogen agonist in bone, while acting as an antagonist in breast and uterine tissues, reducing the risk of estrogen-driven cancers.
Common Dosages
- Tablets: 60 mg
Typical Dosing
- The typical dose for Evista is 60 mg once daily, with or without food.
Typical Dosing
FDA Approved Indications
- Treatment and prevention of osteoporosis in postmenopausal women
- Reduction of risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk of breast cancer
Who Shouldn't Take Evista?
- History of blood clots (deep vein thrombosis, pulmonary embolism)
- Pregnancy or breastfeeding
- Known hypersensitivity to raloxifene
Advice From The Pharmacist
- Take Evista at the same time every day. It can be taken with or without food.
- Ensure you are getting enough calcium and vitamin D in your diet to support bone health while taking Evista.
- Avoid long periods of immobility, as Evista can increase the risk of blood clots.
Side Effects of Evista
Common Side Effects
- Hot flashes
- Leg cramps
- Flu-like symptoms
Uncommon/Severe Side Effects
- Blood clots
- Stroke
- Death due to stroke (in women with known coronary artery disease)
Risks and Warnings of Evista
- Blood Clot Risk: Evista increases the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE), especially in women with a history of clotting disorders or prolonged immobility.
- Stroke Risk: Evista may increase the risk of stroke, particularly in women with coronary artery disease or risk factors for stroke.
Interactions with Evista
Common Drug Interactions
- Warfarin: May decrease the effectiveness of warfarin. Monitoring of INR is recommended.
- Cholestyramine: May decrease the absorption of raloxifene.
Alternatives to Evista
- Fosamax (alendronate)
- Boniva (ibandronate)
- Prolia (denosumab)
