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Duavee
Duavee is a combination of conjugated estrogens and bazedoxifene used to treat menopausal symptoms such as hot flashes and to prevent postmenopausal osteoporosis in women with an intact uterus. The conjugated estrogens help relieve menopause symptoms, while bazedoxifene acts as an estrogen receptor modulator, reducing the risk of endometrial hyperplasia, a condition that can occur with estrogen therapy alone.
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Frequently Asked Questions
How long does it take for Duavee to relieve menopausal symptoms?
Most women start to experience relief from hot flashes within 1-2 weeks, but it may take a few weeks to achieve the full benefit.
Can Duavee be used long-term?
Duavee should be used for the shortest duration possible to relieve menopausal symptoms or prevent osteoporosis, as long-term use may increase the risk of serious side effects like blood clots and breast cancer.
Can Duavee cause weight gain?
Weight gain is not a common side effect of Duavee, but hormonal changes from estrogen therapy can sometimes affect weight. Maintaining a healthy lifestyle can help manage this.
Does Duavee increase the risk of breast cancer?
Yes, long-term use of estrogen therapy, including Duavee, can increase the risk of breast cancer. Regular screenings are recommended.
Can Duavee be used by women without a uterus?
No, Duavee is specifically designed for women with an intact uterus to prevent the risk of endometrial hyperplasia caused by estrogen therapy.
Comprehensive Drug Guide
How Does Duavee Work?
Duavee works by combining the actions of conjugated estrogens, which help replace declining estrogen levels in postmenopausal women, and bazedoxifene, which selectively modulates estrogen receptors. Bazedoxifene prevents estrogen from stimulating the uterine lining, reducing the risk of endometrial hyperplasia while allowing the estrogens to relieve menopausal symptoms.
Common Dosages
- Tablets: 0.45 mg conjugated estrogens / 20 mg bazedoxifene
Typical Dosing
- The typical dosing for Duavee is one tablet taken once daily, with or without food. It is important to take Duavee at the same time each day to maintain consistent hormone levels.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause
- Prevention of postmenopausal osteoporosis in women with an intact uterus
Who Shouldn't Take Duavee?
- Known or suspected breast cancer or estrogen-dependent tumors
- Active or history of venous thromboembolism (VTE)
- Liver disease
- Known pregnancy
- Undiagnosed vaginal bleeding
Advice From The Pharmacist
- Take Duavee at the same time every day to ensure consistent hormone levels and symptom relief.
- Duavee should be used for the shortest duration possible to control menopausal symptoms and prevent osteoporosis.
- Inform your healthcare provider if you have a history of blood clots or breast cancer, as Duavee may not be suitable for you.
Side Effects of Duavee
Common Side Effects
- Muscle spasms
- Nausea
- Diarrhea
- Dizziness
Uncommon/Severe Side Effects
- Increased risk of blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Breast cancer
- Endometrial hyperplasia
Risks and Warnings of Duavee
- Blood Clot Risk: Duavee increases the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). Patients with a history of blood clots should avoid this medication.
- Cancer Risk: Long-term use of estrogen products like Duavee may increase the risk of breast cancer. Regular screenings are recommended.
- Stroke and Cardiovascular Risks: Duavee can increase the risk of stroke and other cardiovascular events, especially in women with underlying risk factors.
Interactions with Duavee
Common Drug Interactions
- Warfarin: Duavee may reduce the effectiveness of blood thinners like warfarin, increasing the risk of blood clots.
- Thyroid medications: Estrogen products like Duavee can interfere with thyroid hormone therapy, requiring dose adjustments.
- Corticosteroids: Concomitant use of Duavee with corticosteroids may increase the risk of side effects like fluid retention.
Alternatives to Duavee
- Premarin (conjugated estrogens): Another estrogen product used for menopause symptom relief.
- Estradiol (oral, patch, or gel): Available in various forms for treating menopausal symptoms.
- Raloxifene: A selective estrogen receptor modulator used for osteoporosis prevention and breast cancer risk reduction.
