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Estrace

Estrace (estradiol) is a form of estrogen used to treat menopausal symptoms, including hot flashes, vaginal dryness, and osteoporosis prevention. It is also used for estrogen replacement in women with ovarian failure or other conditions that cause low levels of natural estrogen. Estrace belongs to the estrogen hormone class and is available in oral, topical, and vaginal forms.



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Frequently Asked Questions

Can Estrace be used long-term?
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Long-term use of Estrace may be considered for certain conditions, but regular monitoring and discussions with your doctor are essential due to the potential risks.

Does Estrace cause weight gain?
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Some women may experience weight gain while taking Estrace, though this is generally mild.

Can Estrace help with osteoporosis?
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Yes, Estrace is used to prevent osteoporosis in postmenopausal women by maintaining bone density.

Is Estrace safe for women with a history of breast cancer?
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Estrace is generally not recommended for women with a history of breast cancer unless specifically advised by a healthcare provider.

Can I use Estrace for vaginal dryness?
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Yes, Estrace vaginal cream is often prescribed for the treatment of vaginal dryness associated with menopause.

Comprehensive Drug Guide

How Does Estrace Work?

Estrace works by replacing natural estrogen in the body, which helps regulate various functions, including maintaining the reproductive system and secondary sexual characteristics in women. It also helps alleviate symptoms associated with menopause by increasing estrogen levels.



Common Dosages

  • Tablets: 0.5 mg, 1 mg, 2 mg
  • Vaginal cream: 0.01%

Typical Dosing

  • For menopausal symptoms, the typical dose is 1 mg to 2 mg once daily.
  • For osteoporosis prevention, the dose may be adjusted based on the patient’s needs.


Typical Dosing

FDA Approved Indications

  • Treatment of menopausal symptoms (hot flashes, vaginal dryness)
  • Prevention of osteoporosis in postmenopausal women
  • Estrogen replace


Who Shouldn't Take Estrace?

  • Known hypersensitivity to estradiol.
  • Breast cancer (except in select patients).
  • Undiagnosed vaginal bleeding.
  • Active or history of blood clots.


Advice From The Pharmacist

  • Take Estrace at the same time every day, with or without food.
  • Vaginal creams or topical forms of Estrace should be applied as directed by your doctor.
  • Regular monitoring, including breast exams and Pap smears, is important while on Estrace.


Side Effects of Estrace

Common Side Effects

  • Breast tenderness
  • Nausea
  • Bloating
  • Headache


Uncommon/Severe Side Effects

  • Blood clots
  • Stroke
  • Breast cancer


Risks and Warnings of Estrace

  • Blood Clot Risk: Estrace increases the risk of blood clots, stroke, and heart attack, especially in women who smoke or have underlying cardiovascular conditions.
  • Cancer Risk: Long-term use of Estrace may increase the risk of breast cancer or endometrial cancer. Regular screening is recommended.


Interactions with Estrace

Common Drug Interactions

  • Grapefruit juice: May increase the levels of estradiol in the blood, leading to potential side effects.
  • Anticonvulsants: Medications like phenytoin or carbamazepine may reduce the effectiveness of Estrace.


Alternatives to Estrace

  • Premarin (conjugated estrogens)
  • Climara (estradiol transdermal patch)
  • Femring (estradiol vaginal ring)