You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
Vagifem
Vagifem (generic name: estradiol vaginal tablets) is a local estrogen therapy used to treat symptoms of vaginal atrophy due to menopause, such as vaginal dryness, itching, burning, and painful intercourse (dyspareunia). Vagifem contains estradiol, a form of estrogen that helps to replenish the hormone levels in the vaginal tissue, promoting healing and restoring moisture.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with Vagifem ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long does it take for Vagifem to work?
You may start to notice improvement in symptoms such as vaginal dryness and discomfort within a few weeks of starting Vagifem, but it may take several weeks for full benefits.
Can Vagifem be used long-term?
Yes, Vagifem can be used long-term, but your healthcare provider will likely recommend regular follow-up visits to assess the ongoing need for treatment and monitor for any potential risks.
Does Vagifem increase the risk of cancer?
In women with a uterus, unopposed estrogen therapy can increase the risk of endometrial cancer. Your healthcare provider may suggest using a progestin in combination with Vagifem to reduce this risk. Breast cancer risk may also be increased with long-term estrogen use.
Can Vagifem be used with other medications?
Yes, Vagifem is generally safe to use with most medications, but be sure to inform your healthcare provider of all other treatments you're using, especially systemic hormone therapies or thyroid medications.
Is Vagifem safe for women who have had a hysterectomy?
Yes, Vagifem can be safely used by women who have had a hysterectomy, as the risk of endometrial cancer (associated with unopposed estrogen therapy) is no longer a concern.
Comprehensive Drug Guide
How Does Vagifem Work?
Vagifem contains estradiol, a type of estrogen hormone. When applied locally, it helps restore the vaginal epithelium (lining of the vaginal walls) by increasing cell growth, reducing vaginal pH, and increasing natural lubrication. This relieves symptoms of vaginal atrophy caused by decreased estrogen levels during menopause.
Common Dosages
- 10 mcg vaginal tablets.
- 25 mcg vaginal tablets (less commonly prescribed due to lower dosing guidelines).
Typical Dosing
- The initial dose for treating vaginal atrophy is typically one 10 mcg tablet inserted vaginally once daily for the first two weeks.
- After the initial two weeks, the maintenance dose is usually one tablet twice weekly (e.g., Monday and Thursday).
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vaginal atrophy due to menopause, specifically for symptoms such as vaginal dryness, burning, itching, and pain during intercourse.
Who Shouldn't Take Vagifem?
- Undiagnosed abnormal genital bleeding.
- Known or suspected breast cancer or other hormone-sensitive cancers.
- Active or recent history of venous thromboembolism (blood clots).
- Liver dysfunction or disease.
- Pregnancy or breastfeeding.
Advice From The Pharmacist
- Use the Vagifem applicator to insert the tablet into the vagina. Follow the instructions provided by your healthcare provider on how to properly use the applicator.
- Continue using Vagifem as prescribed, even after symptoms improve, to maintain the health of vaginal tissues.
- Inform your healthcare provider if you experience any abnormal vaginal bleeding while using Vagifem.
- Store Vagifem at room temperature, away from excessive heat and moisture.
Side Effects of Vagifem
Common Side Effects
- Vaginal discomfort or irritation
- Headache
- Abdominal pain or bloating
- Breast tenderness
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis or pulmonary embolism)
- Stroke or heart attack
- Breast cancer
- Endometrial cancer (in women with a uterus who do not use a progestin)
Risks and Warnings of Vagifem
- Endometrial Cancer: In women with a uterus, unopposed estrogen therapy (without progestin) may increase the risk of endometrial hyperplasia, which can lead to cancer. Regular monitoring and possibly adding a progestin may be necessary.
- Cardiovascular Risks: Estrogen therapy, including Vagifem, may increase the risk of blood clots, stroke, and heart attack, especially in women with preexisting cardiovascular risk factors.
- Breast Cancer: Estrogen use has been associated with an increased risk of breast cancer. Regular breast exams and mammograms are recommended while using Vagifem.
Interactions with Vagifem
Common Drug Interactions
- Systemic estrogens: While Vagifem delivers low-dose, local estrogen, caution should be used when combining it with systemic estrogen therapies to avoid excessive hormone levels.
- Thyroid medications: Estrogen may affect the efficacy of thyroid hormone replacement therapy, and thyroid function should be monitored.
Alternatives to Vagifem
- Premarin Vaginal Cream: Another estrogen-based cream used to treat symptoms of vaginal atrophy.
- Estrace Vaginal Cream: A vaginal cream that delivers estradiol for treating vaginal dryness and other symptoms of menopause.
- Intrarosa (prasterone): A non-estrogen option for treating pain during intercourse in postmenopausal women.
- Replens: A non-hormonal over-the-counter vaginal moisturizer used to alleviate dryness.
