You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
Depo-Estradiol
Depo-Estradiol (estradiol cypionate) is a hormone replacement therapy (HRT) used to treat symptoms of menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention in postmenopausal women. It contains estradiol, a form of estrogen, which helps replenish declining hormone levels during menopause. Depo-Estradiol is administered as an intramuscular injection, offering a longer duration of action compared to oral or topical estrogen therapies.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with Depo-Estradiol ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long does it take for Depo-Estradiol to start working?
Some patients may notice relief from menopausal symptoms within the first few weeks of treatment. However, it may take up to a few months to experience the full effects.
How often do I need Depo-Estradiol injections?
Depo-Estradiol is typically injected every 3 to 4 weeks, depending on your symptoms and how your body responds to treatment.
Can Depo-Estradiol increase the risk of cancer?
Yes, prolonged estrogen therapy without the addition of progesterone may increase the risk of certain cancers, such as breast and endometrial cancer. Regular check-ups and screenings are essential.
Is Depo-Estradiol safe to use long-term?
Depo-Estradiol can be used long-term under careful medical supervision. Your healthcare provider will regularly assess the risks and benefits of continuing therapy, especially as they relate to cancer and cardiovascular health.
What should I do if I miss a Depo-Estradiol injection?
If you miss a scheduled injection, contact your healthcare provider to reschedule it as soon as possible. Do not double up on injections to make up for the missed dose.
Comprehensive Drug Guide
How Does Depo-Estradiol Work?
Depo-Estradiol works by supplementing estradiol, the main form of estrogen produced by the ovaries. As estrogen levels decline during menopause, symptoms such as hot flashes and vaginal dryness can occur. Estradiol helps restore hormonal balance and reduce these symptoms, while also maintaining bone density to prevent osteoporosis.
What is Depo-Estradiol Used For?
- Treatment of menopausal symptoms (e.g., hot flashes, vaginal atrophy)
- Prevention of postmenopausal osteoporosis
Common Dosages
Depo-Estradiol is available in the following strengths:
- 5 mg/mL injection
- 10 mg/mL injection
Typical Dosing
FDA Approved Indications
- For menopausal symptoms, the typical dose is 1 to 5 mg injected every 3 to 4 weeks. The dosing schedule may vary based on the severity of symptoms and individual patient response.
Off-Label Uses
Who Shouldn't Take Depo-Estradiol?
Depo-Estradiol should not be used in individuals with:
- A history of breast cancer or estrogen-dependent cancers
- Undiagnosed abnormal vaginal bleeding
- Liver disease
- Active or past history of blood clots
- Known hypersensitivity to estradiol or any components in the formulation
Advice From The Pharmacist
- Depo-Estradiol is administered via intramuscular injection, typically by a healthcare provider, although some patients may be trained for self-administration.
- If you miss an injection, consult your healthcare provider to reschedule the next dose.
- Discuss your complete medical history with your healthcare provider, including any family history of breast cancer or cardiovascular disease, as these may affect your suitability for estrogen therapy.
- Avoid smoking while on estrogen therapy, as it increases the risk of blood clots, stroke, and heart attack.
Side Effects of Depo-Estradiol
Common Side Effects
- Headaches
- Nausea
- Breast tenderness
- Bloating
- Vaginal spotting or breakthrough bleeding
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- Increased risk of breast cancer
- Gallbladder disease
Risks and Warnings of Depo-Estradiol
Blood Clot Risk: Estrogen therapy can increase the risk of blood clots, particularly in women with a history of smoking or certain medical conditions. Patients should be monitored for signs of blood clots, such as leg pain or swelling.
Cancer Risk: Prolonged use of estrogen therapy may increase the risk of certain cancers, including breast and endometrial cancer. Regular screenings are essential for early detection.
Cardiovascular Events: Women with a history of cardiovascular disease should use Depo-Estradiol with caution due to the increased risk of heart attack and stroke.
Interactions with Depo-Estradiol
Common Drug Interactions
- Blood thinners: Depo-Estradiol may increase the risk of bleeding when taken with anticoagulants like warfarin.
- CYP3A4 inhibitors: Medications like ketoconazole may increase estradiol levels, leading to a higher risk of side effects.
- Thyroid medications: Estrogen can interfere with thyroid hormone replacement therapy, requiring dose adjustments.
Alternatives to Depo-Estradiol
- Oral estrogen tablets: Estrace or Premarin, for patients who prefer oral hormone replacement.
- Transdermal estrogen patches: Estradiol patches (Climara, Vivelle-Dot) provide a non-invasive option for continuous estrogen delivery.
- Vaginal estrogen creams: For patients with localized menopausal symptoms, such as vaginal dryness.
