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Estrogel
Estrogel (generic name: estradiol) is a topical hormone replacement therapy (HRT) used to treat symptoms of menopause, such as hot flashes, vaginal dryness, and mood swings. It contains estradiol, a form of estrogen, which helps to replace the hormone levels that decline during menopause, relieving menopausal symptoms.
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Frequently Asked Questions
How long does it take for Estrogel to start working?
It may take several weeks for symptoms to improve after starting Estrogel, but some relief may be noticed within the first few days of use.
Can Estrogel cause weight gain?
Weight gain is not a common side effect of Estrogel, but changes in body fat distribution can occur during menopause and HRT.
How should I store Estrogel?
Store Estrogel at room temperature and keep it away from excessive heat and light.
Can I use Estrogel if I still have my uterus?
If you still have your uterus, your healthcare provider may recommend adding progestin to your HRT to reduce the risk of endometrial cancer.
Can I use Estrogel if I'm breastfeeding?
Estrogen can pass into breast milk, so it's generally not recommended for women who are breastfeeding. Consult your healthcare provider for alternative treatments.
Comprehensive Drug Guide
How Does Estrogel Work?
Estrogel delivers estradiol through the skin into the bloodstream, where it helps to replenish declining estrogen levels during menopause. By restoring estrogen, Estrogel helps alleviate common menopausal symptoms like hot flashes and vaginal dryness.
Common Dosages
- 0.06% (0.75 mg of estradiol per actuation)
Typical Dosing
- Apply one pump of gel daily, usually on the upper arm or shoulder. It is recommended to use it at the same time each day.
Typical Dosing
FDA Approved Indications
- Moderate to severe vasomotor symptoms associated with menopause (hot flashes)
- Vulvar and vaginal atrophy due to menopause
Who Shouldn't Take Estrogel?
- Undiagnosed abnormal vaginal bleeding
- Breast cancer
- Active or history of thromboembolic disorders (blood clots)
- Liver disease
Advice From The Pharmacist
- Apply Estrogel only to clean, dry skin and allow it to dry completely before covering with clothing.
- Avoid contact with the eyes and face. Do not wash the area for at least 1 hour after applying the gel.
- If you miss a dose, apply it as soon as you remember. Do not double up doses.
- Report any unusual vaginal bleeding to your healthcare provider, as it may indicate a more serious condition.
Side Effects of Estrogel
Common Side Effects
- Skin irritation at the application site
- Breast tenderness
- Headache
- Nausea
Uncommon/Severe Side Effects
- Blood clots
- Stroke
- Heart attack
- Breast or uterine cancer
Risks and Warnings of Estrogel
- Blood Clots and Stroke: Estrogen use can increase the risk of blood clots and stroke, particularly in women over 50. Use the lowest effective dose for the shortest duration.
- Cancer Risk: Long-term use of estrogen may increase the risk of breast cancer and endometrial cancer. Women with a uterus should consider using progestin along with estrogen to reduce the risk of uterine cancer.
Interactions with Estrogel
Common Drug Interactions
- Warfarin: Estrogen can affect the effectiveness of blood thinners like warfarin.
- CYP3A4 inhibitors: Drugs that affect this enzyme may alter the metabolism of estradiol, affecting its effectiveness.
Alternatives to Estrogel
- Estrace (estradiol): An oral or vaginal form of estrogen for hormone replacement therapy.
- Premarin (conjugated estrogens): Another estrogen replacement therapy, available in tablet and vaginal cream forms.
- Climara: A transdermal estrogen patch used for hormone replacement therapy.
