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Dotti
Dotti (generic name: doxylamine succinate) is an antihistamine used primarily as a sleep aid and for the relief of symptoms associated with allergies, hay fever, and the common cold. Doxylamine has sedative properties, making it effective in helping individuals fall asleep more easily.
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Frequently Asked Questions
How long does it take for Dotti to work?
Patients may start to notice effects within 30 minutes of taking Dotti, with peak effects occurring around 1 to 2 hours after administration.
Can Dotti be taken during pregnancy?
Dotti should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Dotti?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Dotti?
There are no specific dietary restrictions while taking Dotti.
Is Dotti safe for long-term use?
Dotti is generally recommended for short-term use; prolonged use should be monitored by a healthcare provider to avoid tolerance and dependence.
Comprehensive Drug Guide
How Does Dotti Work?
- Blocking histamine receptors: It inhibits the action of histamine at H1 receptors, which helps reduce allergy symptoms such as runny nose and sneezing.
- Sedative effects: By crossing the blood-brain barrier, doxylamine causes sedation, helping to promote sleep.
Common Dosages
- Tablets: Usually available in strengths of 25 mg.
Typical Dosing
- For sleep aid: The usual adult dosage is 25 mg, taken 30 minutes before bedtime.
- For allergy relief: The typical dose is 12.5 mg to 25 mg taken every 4 to 6 hours, not exceeding 75 mg in 24 hours.
Typical Dosing
FDA Approved Indications
- Relief of symptoms due to hay fever or other upper respiratory allergies.
- Short-term treatment of insomnia.
Who Shouldn't Take Dotti?
- Known hypersensitivity to doxylamine or any components of the formulation.
- Glaucoma, asthma, or urinary retention.
Advice From The Pharmacist
- Take Dotti as directed and avoid combining it with other CNS depressants, such as alcohol or benzodiazepines, due to the increased risk of sedation.
- Monitor for any side effects, such as dizziness or dry mouth, and report any severe reactions to your healthcare provider.
- Avoid driving or operating machinery until you know how Dotti affects you, as it may cause drowsiness.
Side Effects of Dotti
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Blurred vision
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
Risks and Warnings of Dotti
- Cognitive Effects: Use caution in elderly patients, as antihistamines can increase the risk of cognitive impairment and falls.
- Anticholinergic Effects: Dotti may cause side effects related to anticholinergic activity, such as urinary retention and blurred vision.
Interactions with Dotti
Common Drug Interactions
- Other sedatives: Caution should be exercised when using Dotti with other medications that can cause sedation, such as benzodiazepines and alcohol.
- MAO inhibitors: Concurrent use with monoamine oxidase inhibitors should be avoided due to the risk of increased side effects.
Alternatives to Dotti
- Other antihistamines: Such as diphenhydramine or chlorpheniramine, which may also be used for allergy relief and sedation.
- Non-sedating antihistamines: Such as loratadine or cetirizine, for allergy relief without sedation.
