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Alora
Alora (generic name: estradiol transdermal system) is a hormone replacement therapy (HRT) patch that delivers estradiol, a form of estrogen, through the skin to help manage symptoms of menopause such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. It is primarily used in women who are experiencing menopausal symptoms due to the body's reduced estrogen production. Estradiol helps replenish hormone levels, easing menopausal discomfort and preventing long-term complications like bone loss.
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Frequently Asked Questions
How long does it take for Alora to start working?
Most patients start to notice improvement in symptoms like hot flashes within a few weeks of starting Alora, though full benefits may take several months.
Can Alora help with bone health?
Yes, Alora helps prevent bone loss and can be prescribed for the prevention of osteoporosis in postmenopausal women at risk of fractures.
What should I do if my Alora patch falls off?
If your patch falls off, try to reapply it. If it doesn’t stick, apply a new patch and continue with your regular dosing schedule.
Can I use Alora during pregnancy?
No, Alora is contraindicated during pregnancy. If you become pregnant while using the patch, discontinue use and consult your healthcare provider immediately.
Is Alora safe for long-term use?
Long-term use of hormone replacement therapy may carry increased risks, including cardiovascular events and certain cancers. It’s important to have regular check-ups with your healthcare provider to assess whether continuing Alora is appropriate for you.
Comprehensive Drug Guide
How Does Alora Work?
Alora delivers estradiol through the skin, where it is absorbed into the bloodstream. Estradiol replaces the estrogen that the body no longer produces in sufficient amounts during menopause. Estrogen plays a vital role in regulating many functions in the body, including maintaining bone density, controlling body temperature, and keeping the vaginal lining healthy. By supplementing estrogen levels, Alora helps manage menopausal symptoms and prevent bone loss associated with osteoporosis.
Common Dosages
- 0.025 mg/day
- 0.05 mg/day
- 0.075 mg/day
- 0.1 mg/day
Typical Dosing
- Apply the Alora patch to a clean, dry area of the skin, usually on the lower abdomen or buttocks. The patch should be changed twice a week (every 3 to 4 days).
- The dosage strength and frequency of patch changes will depend on the severity of symptoms and your healthcare provider’s recommendation.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vasomotor symptoms (hot flashes, night sweats) associated with menopause.
- Treatment of vulvar and vaginal atrophy (vaginal dryness and irritation) due to menopause.
- Prevention of postmenopausal osteoporosis in women at risk for bone loss.
Who Shouldn't Take Alora?
- Undiagnosed abnormal vaginal bleeding
- Active or history of breast cancer
- Known or suspected pregnancy
- Active blood clots or history of thromboembolic disease
- Severe liver disease
Advice From The Pharmacist
- Apply Alora to the lower abdomen or buttocks, rotating the application site with each new patch to avoid skin irritation.
- Avoid applying the patch to the breasts or areas where the skin is oily, broken, or irritated.
- If a patch falls off, try reapplying it to a different area, but if it won’t stick, apply a new patch immediately and continue your normal patch-changing schedule.
- Alora patches should not be exposed to heat sources, such as heating pads or hot baths, as this may increase the release of estradiol from the patch.
Side Effects of Alora
Common Side Effects
- Skin irritation at the patch application site
- Nausea
- Breast tenderness
- Headache
- Bloating
Uncommon/Severe Side Effects
- Blood clots
- Stroke or heart attack
- Increased risk of breast or uterine cancer
Risks and Warnings of Alora
- Cardiovascular Risks: Estrogen replacement therapy can increase the risk of heart attack, stroke, and blood clots, especially in older women or those with other risk factors like smoking.
- Cancer Risk: Long-term use of estrogen, particularly without progesterone in women with an intact uterus, can increase the risk of endometrial and breast cancer.
- Liver Effects: Alora may cause liver problems in patients with pre-existing liver conditions.
Interactions with Alora
Common Drug Interactions
- Blood thinners: Medications such as warfarin may have their effectiveness altered when taken with estrogen therapy.
- Thyroid medications: Hormone replacement therapy can affect thyroid levels, requiring adjustments in the dosage of thyroid hormone medications.
- CYP3A4 inhibitors: Drugs such as ketoconazole or ritonavir may increase blood levels of estradiol, raising the risk of side effects.
Alternatives to Alora
- Climara: Another transdermal estradiol patch used for similar symptoms and conditions.
- Estrace: An oral form of estradiol used for hormone replacement therapy.
- Premarin: A conjugated estrogen therapy for menopause symptoms.
- Non-hormonal options: Drugs like SSRIs or gabapentin can help manage hot flashes in women who cannot use estrogen therapy.
