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Elestrin
Elestrin is a brand name for estradiol, a form of estrogen hormone used to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and irritation. Estradiol is the primary estrogen hormone produced by the ovaries and is often prescribed as part of hormone replacement therapy (HRT) for women experiencing menopause. Elestrin comes in the form of a topical gel, which is applied to the skin, allowing estradiol to be absorbed into the bloodstream to alleviate menopausal symptoms.
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Frequently Asked Questions
How long does it take for Elestrin to start working?
Many women experience relief from hot flashes and other menopausal symptoms within 1 to 2 weeks of starting Elestrin. Full benefits may take a few weeks.
Can I use Elestrin if I still have my uterus?
If you have an intact uterus, your doctor may prescribe a progestin along with Elestrin to reduce the risk of endometrial cancer.
What should I do if I miss a dose of Elestrin?
If you miss a dose, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra gel to make up for a missed dose.
Can I use Elestrin for vaginal dryness?
Yes, Elestrin can help improve vaginal dryness associated with menopause. However, for severe vaginal symptoms, a local vaginal estrogen product may be more effective.
Is there an increased risk of cancer with Elestrin?
Long-term use of estrogen products may increase the risk of breast cancer, endometrial cancer, and other estrogen-dependent cancers. It’s important to discuss these risks with your healthcare provider before starting treatment. Regular screenings are recommended.
Comprehensive Drug Guide
How Does Elestrin Work?
Estradiol in Elestrin works by replacing the estrogen that the body no longer produces after menopause. Estrogen helps regulate various bodily functions, including temperature control, vaginal health, and bone density. By supplementing estradiol, Elestrin helps reduce the frequency and severity of menopausal symptoms such as hot flashes and vaginal dryness.
Common Dosages
Elestrin is available in a topical gel formulation. The usual strength is:
- 0.06% transdermal gel (0.87 grams delivers 0.52 mg of estradiol)
Typical Dosing
- The typical dose of Elestrin is 0.87 grams of the gel applied to the upper arm or shoulder once daily.
- The dosage may be adjusted by your healthcare provider based on the severity of symptoms and response to treatment.
Typical Dosing
FDA Approved Indications
- Moderate to severe vasomotor symptoms (hot flashes) associated with menopause
- Vaginal atrophy and related symptoms (such as dryness and irritation) due to menopause
Who Shouldn't Take Elestrin?
- Known hypersensitivity to estradiol or any component of the gel
- Undiagnosed abnormal vaginal bleeding
- History of breast cancer or estrogen-dependent cancers
- Active or history of blood clots, stroke, or heart attack
- Liver dysfunction or disease
Advice From The Pharmacist
- Apply Elestrin gel to clean, dry skin on the upper arm or shoulder. Avoid applying the gel to irritated or broken skin.
- After applying the gel, allow it to dry completely before dressing and avoid washing the area for at least one hour.
- Avoid exposing the application site to direct sunlight, as this may affect the absorption of the medication.
- Do not apply the gel to the breasts or vaginal area.
Side Effects of Elestrin
Common Side Effects
- Skin redness or irritation at the application site
- Headache
- Breast tenderness
- Nausea
- Bloating
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- Breast cancer or other estrogen-related cancers
- Liver problems (yellowing of the skin or eyes)
Risks and Warnings of Elestrin
- Cardiovascular Risk: Estrogen-containing products like Elestrin may increase the risk of blood clots, stroke, and heart attack, especially in women who smoke or have underlying cardiovascular conditions.
- Breast Cancer Risk: Long-term use of estrogen therapy may increase the risk of breast cancer. Regular breast exams and mammograms are recommended during treatment.
- Endometrial Cancer: Women with an intact uterus who use estrogen alone without progesterone may have an increased risk of endometrial cancer.
Interactions with Elestrin
Common Drug Interactions
- Blood Thinners: Using Elestrin with anticoagulants like warfarin may reduce the effectiveness of blood thinners and increase the risk of clotting.
- Thyroid Hormone Replacement: Estrogen can affect the levels of thyroid hormones in the blood. Dose adjustments may be necessary.
- CYP3A4 Inhibitors: Drugs like ketoconazole or ritonavir may increase estradiol levels and the risk of side effects.
Alternatives to Elestrin
- Estradiol Transdermal Patch (Vivelle-Dot, Climara): A patch that delivers estradiol through the skin for menopausal symptom relief.
- Premarin (Conjugated Estrogens): An oral or topical estrogen used to treat menopausal symptoms.
- Estrogel: Another estradiol transdermal gel option for managing hot flashes and vaginal atrophy.
- Bioidentical Hormone Replacement Therapy (BHRT): Customized hormone therapy options that may be available for some women.
