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Bijuva
Bijuva is a hormone replacement therapy (HRT) designed for women experiencing moderate to severe vasomotor symptoms (such as hot flashes) due to menopause. It combines estradiol (a form of estrogen) and progesterone, which helps alleviate symptoms of estrogen deficiency while reducing the risk of endometrial hyperplasia (a thickening of the uterine lining) that can occur with estrogen-only therapies in women with a uterus.
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Frequently Asked Questions
How soon does Bijuva start working?
Most women start to experience relief from hot flashes within a few weeks, but it may take up to three months for the full effects to be noticeable.
Can Bijuva be used long-term?
Bijuva is typically used for short-term relief of menopausal symptoms, with regular medical evaluations to assess risks and benefits for continued use.
What should I do if I miss a dose of Bijuva?
If you miss a dose, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and do not double up on doses.
Can Bijuva cause weight gain?
Weight gain is a possible side effect of hormone replacement therapy, but not all women experience it. Maintaining a healthy diet and lifestyle can help mitigate this effect.
Can Bijuva be used if I’ve had a hysterectomy?
No, Bijuva is designed for women with an intact uterus. If you’ve had a hysterectomy, estrogen-only therapy may be more appropriate.
Comprehensive Drug Guide
How Does Bijuva Work?
Bijuva works by supplementing estradiol, which compensates for the natural decline of estrogen levels during menopause, helping to relieve hot flashes and other symptoms associated with menopause. The progesterone component ensures protection of the uterine lining, preventing the overgrowth of cells (endometrial hyperplasia) that could lead to cancer if only estrogen were administered.
Common Dosages
- Capsules: 1 mg estradiol / 100 mg progesterone.
.Typical Dosing
- The typical dosing is one capsule daily, taken with food.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vasomotor symptoms associated with menopause in women with an intact uterus.
Who Shouldn't Take Bijuva?
- Undiagnosed abnormal vaginal bleeding
- Known or suspected breast cancer
- Liver disease
- Blood clots, stroke, or heart disease
- Pregnancy
Advice From The Pharmacist
- Take Bijuva with food to enhance absorption and reduce stomach discomfort.
- It is important to have regular follow-ups with your healthcare provider while on hormone therapy to monitor for any potential side effects or complications.
- If you miss a dose, take it as soon as possible, but do not double up on doses.
Side Effects of Bijuva
Common Side Effects
- Breast tenderness
- Headache
- Vaginal bleeding
- Nausea
Uncommon/Severe Side Effects
- Blood clots
- Stroke
- Breast cancer
Risks and Warnings of Bijuva
- Cardiovascular risk: Estrogen-containing therapies, including Bijuva, increase the risk of heart attack, stroke, and blood clots, especially in women who smoke or are over the age of 60.
- Cancer risk: Long-term hormone therapy can increase the risk of breast cancer.
Interactions with Bijuva
Common Drug Interactions
- Antibiotics (such as rifampin) and antifungals (like ketoconazole) may affect Bijuva’s metabolism.
- Blood thinners: Bijuva may alter the effects of anticoagulants like warfarin, which can increase the risk of bleeding.
Alternatives to Bijuva
- Prempro: A combination of conjugated estrogens and medroxyprogesterone.
- Estrace + Prometrium: Separate oral estrogen and progesterone pills for similar hormone therapy.
- Climara Pro: A transdermal patch containing estradiol and levonorgestrel.
