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Delestrogen
Delestrogen (generic name: estradiol valerate) is a form of estrogen used in hormone replacement therapy (HRT) to manage symptoms associated with menopause, such as hot flashes, vaginal dryness, and irregular periods. It is also used for conditions that require estrogen supplementation, including hypoestrogenism due to ovarian failure or removal, and as part of hormone therapy for transgender women. Delestrogen is an injectable form of estradiol, which is the primary estrogen hormone produced by the ovaries.
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Frequently Asked Questions
How long does it take for Delestrogen to start working?
You may start to feel relief from menopausal symptoms within a few weeks, but full effects can take up to 3 months of consistent use.
Can Delestrogen be used for transgender women?
Yes, Delestrogen is commonly used as part of hormone replacement therapy for transgender women to promote feminization by providing estrogen.
What should I do if I miss a dose of Delestrogen?
If you miss a dose, take it as soon as possible. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Is Delestrogen safe for long-term use?
Long-term use of Delestrogen can be safe when closely monitored by a healthcare provider, but it may increase the risk of blood clots and certain cancers. Regular check-ups and screenings are important.
Can Delestrogen cause weight gain?
Some individuals may experience weight gain while using Delestrogen, though it is usually mild. Discuss any significant weight changes with your doctor.
Comprehensive Drug Guide
How Does Delestrogen Work?
Delestrogen contains estradiol, a synthetic form of the naturally occurring hormone estrogen. Estradiol works by binding to estrogen receptors in various tissues, including the reproductive system, bones, and skin, where it helps regulate numerous bodily functions. In hormone replacement therapy, Delestrogen helps restore estrogen levels, alleviating menopausal symptoms and preventing complications such as bone loss.
Common Dosages
- 10 mg/mL
- 20 mg/mL
- 40 mg/mL injectable solution
Typical Dosing
- For menopausal symptoms: The typical dose ranges from 10 to 20 mg every 4 weeks, adjusted based on individual response.
- For hypoestrogenism: The dosing is individualized and may range from 10 to 40 mg every 2 to 4 weeks, depending on the severity of the condition.
- For transgender women: Dosing is also individualized and typically involves 20 to 40 mg every 2 to 4 weeks.
Typical Dosing
FDA Approved Indications
- Moderate to severe vasomotor symptoms (hot flashes) due to menopause
- Vulvar and vaginal atrophy due to menopause
- Hypoestrogenism due to ovarian failure, removal of ovaries, or primary ovarian insufficiency
- Used as part of gender-affirming hormone therapy for transgender women
Who Shouldn't Take Delestrogen?
- Undiagnosed abnormal vaginal bleeding
- History of breast cancer or estrogen-dependent cancers
- Active or history of blood clots (deep vein thrombosis or pulmonary embolism)
- Liver disease
- Known hypersensitivity to estradiol valerate or any of its components
Advice From The Pharmacist
- Delestrogen is usually administered by a healthcare provider via intramuscular injection. If you are administering it yourself at home, follow the exact instructions provided by your healthcare professional.
- Regular monitoring of hormone levels may be necessary to ensure the dosage is appropriate and to avoid side effects.
- Do not stop taking Delestrogen abruptly; always consult with your doctor before adjusting your dosage.
Side Effects of Delestrogen
Common Side Effects
- Breast tenderness or swelling
- Headache
- Nausea
- Weight changes
- Mood changes
Uncommon/Severe Side Effects
- Increased risk of blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Breast cancer
- Endometrial hyperplasia (thickening of the uterine lining)
Risks and Warnings of Delestrogen
- Blood Clot Risk: Like all estrogen therapies, Delestrogen increases the risk of blood clots, particularly in individuals with a history of thrombosis or cardiovascular disease.
- Cancer Risk: Prolonged use of estrogen therapy has been associated with an increased risk of breast cancer and endometrial cancer. Adding progestin to estrogen therapy may reduce the risk of endometrial cancer in women with a uterus.
Interactions with Delestrogen
Common Drug Interactions
- CYP3A4 inducers (such as rifampin, carbamazepine) can reduce the effectiveness of Delestrogen by increasing its metabolism.
- Anticoagulants: Estrogens can interfere with the effects of blood thinners like warfarin, potentially increasing the risk of clotting.
- Thyroid medications: Estrogen can affect the dosage of thyroid replacement therapies, so thyroid function may need to be monitored.
Alternatives to Delestrogen
- Estradiol patches (Vivelle-Dot): A transdermal form of estrogen therapy.
- Premarin: A conjugated estrogen used for hormone replacement therapy.
- Estrace: Oral or vaginal estradiol for hormone therapy in menopausal women.
