Browse Medications by Drug Class: Keratolytics

Written by Amar Lunagaria
Pharm.D • NiHowdy Founder

Reviewed by James Wong
Pharm.D • NiHowdy Founder
Published Jan 15, 2025

What are Keratolytics?
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List of drugs in Keratolytics
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Brief history about Keratolytics?
How do Keratolytics work?
What are Keratolytics used to treat?
Acne
Keratolytics like salicylic acid and benzoyl peroxide are widely used to treat acne. By exfoliating dead skin cells and unclogging pores, these agents reduce inflammation, prevent new breakouts, and improve skin texture. They are particularly effective for mild to moderate acne and are often included in over-the-counter and prescription skin-care products.
Psoriasis
In psoriasis, keratolytics help manage the excessive skin cell buildup that leads to scaling and plaques. Urea and salicylic acid are commonly used to soften and remove thickened skin, allowing other topical treatments, such as corticosteroids or vitamin D analogs, to penetrate more effectively.
Warts
Salicylic acid is a first-line treatment for warts, working to dissolve the keratin layer and gradually remove the wart tissue. Keratolytics are often used in combination with freezing therapies to enhance treatment outcomes and speed up recovery.
Seborrheic Dermatitis
Keratolytics are used to treat seborrheic dermatitis by reducing scaling and flaking, particularly on the scalp. Agents like salicylic acid and sulfur are included in medicated shampoos to manage symptoms and restore skin health.
Who should consider Keratolytics medications?
Adults
Adults with dermatological conditions such as acne, psoriasis, or warts benefit from keratolytics as part of their skin-care regimen. These treatments provide effective exfoliation, improve the penetration of other topical agents, and enhance overall skin health. Keratolytics are particularly useful for adults managing chronic skin conditions or seeking smoother, clearer skin.
Children
Keratolytics can be used safely in children for conditions like warts, mild acne, or psoriasis under medical supervision. Pediatric formulations ensure appropriate dosing and minimize irritation. Parents appreciate the convenience and effectiveness of these treatments in addressing common skin concerns in younger populations.
Seniors
Seniors with thickened or rough skin, such as corns, calluses, or hyperkeratosis, benefit from keratolytics for maintaining skin health and comfort. These agents are particularly useful for addressing age-related changes in skin texture and reducing discomfort from pressure points. Careful monitoring ensures safety and efficacy in this population.
Are Keratolytics safe?
Can I take Keratolytics during pregnancy?
Are Keratolytics safe to take while lactating?
Are Keratolytics controlled substances?
Side effects of Keratolytics?
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