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Urea Nail

Urea Nail is a topical medication used to treat thickened or damaged nails, particularly in conditions such as onychomycosis (fungal nail infections), psoriasis, or trauma to the nails. It contains urea, a keratolytic agent that works by softening and breaking down the thickened or hardened nail, allowing for easier trimming or removal. Urea Nail helps improve the appearance and health of the nail by promoting smoother and more manageable nail growth.



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Frequently Asked Questions

How long does it take for Urea Nail to work?
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Improvement can typically be seen within a few weeks to months, depending on the severity of the nail condition. Consistent use is important to achieve the best results.

Can I use Urea Nail on my skin?
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Urea Nail is intended for use on nails, particularly thickened or damaged nails. However, urea-based creams are available for skin conditions and can be used to treat dry or rough skin.

How often should I apply Urea Nail?
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Urea Nail is typically applied once or twice daily, depending on your healthcare provider’s instructions. Regular application is important for effective treatment.

Is Urea Nail safe for diabetics?
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Yes, Urea Nail is generally safe for diabetics to use for nail conditions, but it's always best to consult your healthcare provider before starting treatment.

Can Urea Nail treat fungal nail infections?
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While Urea Nail helps soften and thin the nail, making it easier to treat, it is not an antifungal. It is often used in conjunction with antifungal treatments to help remove thickened nails and improve penetration of the antifungal medication.

Comprehensive Drug Guide

How Does Urea Nail Work?

Urea Nail works by breaking down the keratin in thickened nails, which softens and thins the nail plate, making it easier to trim or treat. Urea also acts as a humectant, drawing moisture into the nail and surrounding skin, which helps to hydrate and reduce brittleness. This dual action of exfoliating and moisturizing promotes healthier nail growth.



Common Dosages

  • 20% urea
  • 40% urea

The specific strength used depends on the severity of the nail condition.

Typical Dosing

  • Apply a thin layer of Urea Nail to the affected nail(s) once or twice daily, as directed by your healthcare provider.
  • Allow the product to fully absorb before covering the nail with socks, shoes, or gloves.
  • Use regularly for best results, as improvement may take several weeks to months depending on the severity of the condition.


Typical Dosing

FDA Approved Indications

  • Onychomycosis (fungal infections of the nail)
  • Psoriasis affecting the nails
  • Thickened or deformed nails due to injury or other conditions


Who Shouldn't Take Urea Nail?

  • Known hypersensitivity to urea or any of the other ingredients in the product.
  • Open wounds or severe skin irritation around the nail area unless directed by a healthcare provider.


Advice From The Pharmacist

  • Apply Urea Nail to clean, dry nails, and avoid contact with the surrounding skin as it can cause irritation, particularly in higher concentrations.
  • Use caution when applying near broken or irritated skin, as urea can cause a burning or stinging sensation.
  • If your nails are thick and difficult to trim, use Urea Nail as directed for several days to soften the nail before trimming.
  • Be patient, as it may take several weeks to see improvement in nail appearance and thickness.
  • Store the product at room temperature and keep it away from moisture and heat.


Side Effects of Urea Nail

Common Side Effects

  • Mild stinging or burning at the application site
  • Redness or irritation around the nail
  • Dryness or peeling of the skin around the nail


Uncommon/Severe Side Effects

  • Severe irritation or allergic reactions (rash, swelling, difficulty breathing)


Risks and Warnings of Urea Nail

  • Skin Irritation: Urea can cause irritation, especially when applied to broken skin or in higher concentrations. If irritation occurs, stop use and consult your healthcare provider.
  • Avoid Contact with Eyes and Mucous Membranes: Urea can cause irritation if it comes into contact with sensitive areas like the eyes, nose, or mouth. Rinse thoroughly with water if contact occurs.


Interactions with Urea Nail

Common Drug Interactions

  • There are no significant drug interactions associated with Urea Nail when used topically. However, inform your healthcare provider about all other topical treatments or medications you are using to avoid potential skin irritation.

Alternatives to Urea Nail

  • Salicylic Acid: Another keratolytic agent that is commonly used for thickened nails or warts.
  • Terbinafine (Lamisil): An antifungal medication used to treat fungal infections of the nails, available in oral and topical forms.
  • Efinaconazole (Jublia): A topical antifungal treatment specifically for onychomycosis.
  • Ciclopirox (Penlac): A topical antifungal lacquer used to treat mild to moderate fungal infections of the nails.