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Jublia
Jublia (generic name: efinaconazole) is a topical antifungal medication specifically formulated for the treatment of onychomycosis, which is a fungal infection of the toenails or fingernails. Jublia is designed to penetrate the nail and reach the site of infection, effectively targeting the fungus responsible for the infection. It is particularly useful for patients who prefer a topical treatment option or cannot tolerate oral antifungal medications.
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Frequently Asked Questions
How long does it take for Jublia to work?
Patients may start to see improvement in their nail appearance within a few weeks, but complete resolution of the infection can take several months as the nail grows out.
What should I do if I miss an application?
If you miss an application, apply Jublia as soon as you remember. If it’s close to the time of your next scheduled application, skip the missed dose and continue your regular schedule. Do not double up on doses.
Can I use Jublia with other nail products?
It is best to avoid using nail polish or other cosmetic nail products while treating with Jublia, as these can interfere with the medication's effectiveness.
Is Jublia safe for long-term use?
Jublia can be used safely for the duration of treatment as prescribed by your healthcare provider, typically up to 48 weeks.
Are there any special care instructions after using Jublia?
After using Jublia, it’s important to monitor for any adverse effects and continue to take precautions against nail infections, especially in individuals with a history of onychomycosis.
Are there any special care instructions after using Jublia?
After using Jublia, it’s important to monitor for any adverse effects and continue to take precautions against nail infections, especially in individuals with a history of onychomycosis.
Comprehensive Drug Guide
How Does Jublia Work?
- Inhibition of ergosterol synthesis: Efinaconazole disrupts the fungal cell membrane by inhibiting the enzyme lanosterol demethylase, which is essential for the synthesis of ergosterol, a vital component of fungal cell membranes.
- This action leads to the death of fungal cells and helps clear the infection from the nail.
Common Dosages
- Apply a thin layer of the solution to the affected toenail and surrounding skin once daily for up to 48 weeks.
Typical Dosing
- For onychomycosis: Apply Jublia once daily to the affected toenail or fingernail, ensuring it is allowed to dry. Continue treatment for up to 48 weeks or as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Onychomycosis (fungal nail infection) caused by Trichophyton rubrum and Trichophyton mentagrophytes.
Who Shouldn't Take Jublia?
- Known hypersensitivity to efinaconazole or any components of the formulation.
- Open wounds or damaged skin in the area where Jublia will be applied.
Advice From The Pharmacist
- Ensure the affected nail is clean and dry before applying Jublia.
- Use the applicator brush to apply the solution to the entire surface of the affected nail and surrounding skin.
- Allow the solution to dry completely before covering the nail or putting on socks or shoes.
- Do not use nail polish or other cosmetic products on the treated nail while using Jublia.
- Follow the prescribed duration of treatment, even if symptoms improve before completing the course.
Side Effects of Jublia
Common Side Effects
- Pain at the application site
- Fatigue
- Nail discoloration
- Nail loss or ingrown nails
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, difficulty breathing)
- Worsening of nail condition or the appearance of new fungal infections.
Risks and Warnings of Jublia
- Local Irritation: Some patients may experience skin irritation at the application site. If severe irritation occurs, discontinue use and consult a healthcare provider.
- Not for Infected Nails: Jublia should not be used on nails that are actively infected or inflamed.
- Superficial Infections: Caution should be taken in patients with superficial infections, as they may require a different treatment approach.
Interactions with Jublia
Common Drug Interactions
- Topical medications: Jublia may interact with other topical treatments applied to the same area. It is best to space applications of different medications to avoid potential interactions.
Alternatives to Jublia
- Kerydin (tavaborole): Another topical solution used to treat onychomycosis with a similar application regimen.
- Ciclopirox (Penlac): A topical antifungal solution that can also be used for fungal nail infections.
- Oral antifungal medications: Such as terbinafine or itraconazole, which may be considered for more extensive fungal infections.
