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Tavaborole
Tavaborole (brand name: Kerydin) is a topical antifungal medication used to treat onychomycosis, a fungal infection of the toenails or fingernails. Onychomycosis is caused by dermatophytes and other fungi that infect the nail, causing discoloration, thickening, and separation from the nail bed. Tavaborole works by inhibiting the fungal enzyme leucyl-tRNA synthetase, which is essential for fungal protein synthesis, leading to the death of the fungus.
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Frequently Asked Questions
How long does it take for tavaborole to work?
Tavaborole must be used for up to 48 weeks to treat onychomycosis because the medication works as the nail grows out. The infection gradually clears as the new, healthy nail replaces the infected nail.
Can I use nail polish while using tavaborole?
No, it is recommended to avoid nail polish or other cosmetic nail products while using tavaborole, as these may interfere with the treatment and prevent the medication from properly reaching the affected area.
What should I do if I miss a dose of tavaborole?
If you miss a dose, apply the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Can tavaborole be used for fungal skin infections?
Tavaborole is specifically indicated for fungal infections of the nails (onychomycosis) and is not approved for use on the skin. For skin fungal infections, other topical or oral antifungal treatments may be more appropriate.
Can tavaborole be used for fingernail infections?
Yes, although tavaborole is most commonly used for toenail onychomycosis, it can also be used to treat fungal infections of the fingernails.
Comprehensive Drug Guide
How Does Tavaborole Work?
Tavaborole works by inhibiting the fungal enzyme leucyl-tRNA synthetase, which is necessary for protein synthesis in fungal cells. By blocking this enzyme, tavaborole prevents the fungus from growing and reproducing, leading to its eventual death. This mechanism helps to clear the fungal infection in the nails.
Common Dosages
- 5% topical solution, typically supplied in a 4 mL or 10 mL bottle with a dropper.
Typical Dosing
- For onychomycosis: Apply once daily to the affected toenail(s) or fingernail(s). Use the provided dropper to apply the solution to the nail surface and under the tip of the nail. Treatment may be required for 48 weeks or longer, as nails grow slowly and the infection may take time to fully clear.
Typical Dosing
FDA Approved Indications
- Onychomycosis of the toenails and fingernails due to Trichophyton rubrum or Trichophyton mentagrophytes.
Who Shouldn't Take Tavaborole?
- Hypersensitivity to tavaborole or any of its components.
Advice From The Pharmacist
- Apply tavaborole once daily, making sure the solution covers the entire affected nail and the skin under the nail tip. Use the dropper provided and avoid using more solution than directed.
- Be patient, as treating onychomycosis takes time. Treatment with tavaborole can take up to 48 weeks (nearly a year) to fully clear the infection as the infected nail grows out.
- Avoid contact with surrounding skin to prevent irritation. If the solution comes into contact with other skin areas, wipe it off immediately.
- Do not use nail polish or other cosmetic nail products while using tavaborole, as this may interfere with the treatment.
- Store the bottle in a cool, dry place and make sure it is tightly closed after each use.
Side Effects of Tavaborole
Common Side Effects
- Redness or irritation at the application site
- Ingrown toenail
- Skin peeling around the nail
- Itching or stinging sensation
Uncommon/Severe Side Effects
- Severe allergic reactions, such as swelling, rash, or difficulty breathing.
Risks and Warnings of Tavaborole
- Skin Irritation: Tavaborole may cause mild irritation or redness around the treated nail. If irritation becomes severe, stop using the medication and consult your healthcare provider.
- Long Treatment Duration: Treating onychomycosis can take up to 48 weeks or longer. Consistency with the daily application is critical for achieving the best results.
- Systemic Absorption: Tavaborole is a topical medication and is not significantly absorbed into the bloodstream, so systemic side effects are very rare.
Interactions with Tavaborole
Common Drug Interactions
Since tavaborole is a topical medication, it has minimal risk of systemic drug interactions. However, avoid using other topical treatments on the affected nails unless recommended by your doctor, as they may interfere with the effectiveness of tavaborole.
Alternatives to Tavaborole
- Ciclopirox (Penlac): A topical antifungal lacquer used for onychomycosis, applied daily.
- Efinaconazole (Jublia): Another topical antifungal solution used to treat onychomycosis, applied once daily for up to 48 weeks.
- Terbinafine (Lamisil): An oral antifungal medication often used to treat more severe or widespread onychomycosis.
- Itraconazole (Sporanox): An oral antifungal option used for fungal nail infections, taken in cycles or continuously over several months.
