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Kerydin
Kerydin (tavaborole) is a topical antifungal medication primarily used to treat onychomycosis, which is a fungal infection of the toenails or fingernails. It is designed to penetrate the nail to reach the site of infection, effectively targeting the fungus. Kerydin is typically prescribed for individuals who have not responded well to other antifungal treatments or who cannot use oral antifungal medications.
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Frequently Asked Questions
How long does it take for Kerydin to work?
Patients may start to see improvement in their nail appearance within a few weeks, but complete resolution of the infection can take several months, as the nail grows out.
What should I do if I miss an application?
If you miss an application, apply Kerydin as soon as you remember. If it’s close to the time of your next scheduled application, skip the missed dose and resume your regular schedule. Do not double up on doses.
Can I use Kerydin with other nail products?
It is best to avoid using nail polish or other cosmetic nail products while treating with Kerydin, as these can interfere with the medication's effectiveness.
Is Kerydin safe during pregnancy?
Kerydin should be used during pregnancy only if the potential benefits justify the risks. Consult your healthcare provider for personalized advice.
Can Kerydin be used on toenails and fingernails?
Yes, Kerydin can be used for both toenails and fingernails affected by onychomycosis, following the same application instructions.
Comprehensive Drug Guide
How Does Kerydin Work?
Kerydin works by inhibiting the fungal enzyme leucyl-tRNA synthetase, which is essential for protein synthesis in fungi. By blocking this enzyme, Kerydin disrupts fungal cell function and ultimately leads to cell death. This action helps to clear the fungal infection from the nail.
Common Dosages
- Apply a thin layer of the solution to the affected nail and surrounding skin once daily for up to 48 weeks.
Typical Dosing
- For onychomycosis: Apply Kerydin once daily to the affected toenail or fingernail, ensuring it is allowed to dry. Continue treatment for up to 48 weeks or as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Onychomycosis (fungal nail infection) caused by Trichophyton rubrum and Trichophyton mentagrophytes.
Who Shouldn't Take Kerydin?
- Known hypersensitivity to tavaborole or any components of the formulation.
- Open wounds or damaged skin in the area where Kerydin will be applied.
Advice From The Pharmacist
- Ensure the affected nail is clean and dry before applying Kerydin.
- Use the applicator brush to apply the solution to the entire surface of the affected nail and surrounding skin.
- Allow the solution to dry completely before covering the nail or putting on socks or shoes.
- Do not use nail polish or other cosmetic products on the treated nail while using Kerydin.
- Follow the prescribed duration of treatment, even if symptoms improve before completing the course.
Side Effects of Kerydin
Common Side Effects
- Application site reactions (redness, itching, or burning)
- Nail discoloration
- Nail loss or ingrown nails
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Worsening of nail condition or the appearance of new fungal infections.
Risks and Warnings of Kerydin
- Local Irritation: Some patients may experience skin irritation at the application site. If severe irritation occurs, discontinue use and consult a healthcare provider.
- Not for Infected Nails: Kerydin should not be used on nails that are actively infected or inflamed.
- Superficial Infections: Caution should be taken in patients with superficial infections, as they may require a different treatment approach.
Interactions with Kerydin
Common Drug Interactions
- Topical medications: Kerydin may interact with other topical treatments applied to the same area. It is best to space applications of different medications to avoid potential interactions.
Alternatives to Kerydin
- Efinaconazole (Jublia): Another topical solution used to treat onychomycosis with a similar application regimen.
- Ciclopirox (Penlac): A topical antifungal solution that can also be used for fungal nail infections.
- Oral antifungal medications: Such as terbinafine or itraconazole may be considered for more extensive fungal infections.
