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Xurea
Xurea (urea topical) is a keratolytic agent used to treat dry, rough, and scaly skin conditions, such as eczema, psoriasis, ichthyosis, and keratosis pilaris. Urea works by increasing the moisture content in the skin, softening hardened areas, and promoting the natural shedding of dead skin cells. It is commonly used to improve skin hydration and texture and is available in various concentrations depending on the severity of the skin condition.
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Frequently Asked Questions
How long does it take for Xurea to show improvement in my skin condition?
Most patients notice an improvement in skin texture and hydration within 1-2 weeks of regular use. For more severe conditions, it may take longer to see the full benefits.
Can Xurea be used on the face?
Yes, but use lower concentrations (such as 10% urea) on facial skin, as it can be more sensitive than other areas of the body. Avoid contact with the eyes, mouth, and mucous membranes.
Can I use Xurea with other moisturizers or creams?
Yes, you can use Xurea alongside other moisturizers, especially for conditions like eczema or psoriasis. Apply Xurea first, followed by your regular moisturizer to enhance skin hydration.
What should I do if I miss a dose of Xurea?
Apply the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not apply extra product to make up for a missed dose.
Can I use Xurea on my hands and feet for cracked skin?
Yes, higher concentrations of urea (such as 20%-50%) are often used for treating cracked heels or dry, callused skin on the hands and feet. Regular use can help soften and heal rough or thickened skin.
Comprehensive Drug Guide
How Does Xurea Work?
Xurea works by softening and moisturizing the outer layer of the skin (stratum corneum). Urea enhances the skin’s ability to retain water, which helps reduce dryness and scaling. It also helps dissolve the intercellular matrix, which holds dead skin cells together, promoting the natural shedding (desquamation) of hardened or thickened skin. This action makes it effective in conditions where excessive skin buildup occurs.
Common Dosages
- 10% for mild skin hydration
- 20%-40% for moderate conditions
- 50% for severe conditions such as thickened or callused skin
Typical Dosing
- For dry skin or mild conditions: Apply a thin layer of 10% urea cream or lotion to the affected areas once or twice daily.
- For more severe conditions, such as psoriasis or thickened skin: Higher concentrations (e.g., 40%-50% urea) may be used. Apply as directed by your healthcare provider, typically once or twice daily.
Typical Dosing
FDA Approved Indications
- Xerosis (dry skin)
- Ichthyosis
- Psoriasis
- Eczema
- Keratosis pilaris
- Nail disorders (such as onychomycosis or thickened nails)
Who Shouldn't Take Xurea?
- Hypersensitivity to urea or any other ingredients in the formulation.
- Open wounds, burns, or severely irritated skin, unless directed by a healthcare provider.
Advice From The Pharmacist
- Apply Xurea to clean, dry skin. Gently rub the cream or lotion into the skin until it is fully absorbed.
- Avoid applying Xurea to broken, inflamed, or infected skin unless instructed by a healthcare provider.
- Use caution when applying higher concentrations of urea, as it may cause mild irritation, particularly on sensitive areas.
- Moisturize regularly after applying Xurea to maintain skin hydration, especially in cold or dry weather conditions.
- If using Xurea for nail conditions (e.g., thickened nails), consult your doctor on how to use the product effectively.
Side Effects of Xurea
Common Side Effects
- Mild skin irritation
- Redness
- Burning or stinging sensation at the application site
- Peeling or itching
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, swelling, or difficulty breathing
- Severe irritation or worsening of skin condition
Risks and Warnings of Xurea
- Skin Irritation: Higher concentrations of urea (above 20%) may cause skin irritation or burning, particularly when applied to sensitive areas. If irritation occurs, discontinue use and consult your healthcare provider.
- Avoid Broken Skin: Do not apply Xurea to open wounds, severe burns, or inflamed skin without medical advice, as it may cause further irritation.
Interactions with Xurea
Common Drug Interactions
- There are no significant drug interactions with topical Xurea, as it is applied externally. However, if you are using other topical treatments, consult your healthcare provider to ensure safe use, especially if using medications for other skin conditions.
Alternatives to Xurea
- Ammonium lactate (Lac-Hydrin): Another keratolytic used for dry, scaly skin conditions.
- Salicylic acid: Used as a keratolytic to treat skin conditions like psoriasis or calluses.
- Topical corticosteroids: Used for inflammatory skin conditions like eczema or psoriasis in conjunction with moisturizers.
- Ceramide-based moisturizers: Provide barrier support and hydration for dry skin conditions.
