NiHowdy > Drug Classes > Typical Antipsychotics

Browse Medications by Drug Class: Typical Antipsychotics

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Typical Antipsychotics?

Typical antipsychotics, also known as first-generation antipsychotics (FGAs), are a class of medications primarily used to treat psychotic disorders such as schizophrenia. They work by blocking dopamine receptors in the brain, helping to reduce symptoms like hallucinations, delusions, and disorganized thinking. While highly effective for managing positive symptoms of psychosis, typical antipsychotics may also have sedative properties, making them useful for acute agitation. A defining characteristic of these medications is their potent dopamine receptor antagonism, which underlies both their therapeutic effects and potential side effects. NiHowdy ensures affordable access to these essential treatments, supporting patients in managing their mental health effectively.

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List of drugs in Typical Antipsychotics

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Adasuve	Adasuve Information	Adasuve Pricing
chlorproMAZINE HCl	chlorproMAZINE HCl Information	chlorproMAZINE HCl Pricing
Compro	Compro Information	Compro Pricing
fluPHENAZine Decanoate	fluPHENAZine Decanoate Information	fluPHENAZine Decanoate Pricing
fluPHENAZine HCl	fluPHENAZine HCl Information	fluPHENAZine HCl Pricing
Haldol	Haldol Information	Haldol Pricing
Haldol Decanoate	Haldol Decanoate Information	Haldol Decanoate Pricing
Haloperidol	Haloperidol Information	Haloperidol Pricing
Haloperidol Decanoate	Haloperidol Decanoate Information	Haloperidol Decanoate Pricing
Haloperidol Lactate	Haloperidol Lactate Information	Haloperidol Lactate Pricing
Loxapine Succinate	Loxapine Succinate Information	Loxapine Succinate Pricing
Molindone HCl	Molindone HCl Information	Molindone HCl Pricing
Perphenazine	Perphenazine Information	Perphenazine Pricing
Perphenazine-Amitriptyline	Perphenazine-Amitriptyline Information	Perphenazine-Amitriptyline Pricing
Prochlorperazine	Prochlorperazine Information	Prochlorperazine Pricing
Prochlorperazine Edisylate	Prochlorperazine Edisylate Information	Prochlorperazine Edisylate Pricing
Prochlorperazine Maleate	Prochlorperazine Maleate Information	Prochlorperazine Maleate Pricing
Thioridazine HCl	Thioridazine HCl Information	Thioridazine HCl Pricing
Thiothixene	Thiothixene Information	Thiothixene Pricing
Trifluoperazine HCl	Trifluoperazine HCl Information	Trifluoperazine HCl Pricing

Brief history about Typical Antipsychotics?

The development of typical antipsychotics began in the 1950s with the discovery of chlorpromazine, which marked a breakthrough in the treatment of schizophrenia and psychosis. This was followed by the introduction of other FGAs such as haloperidol and fluphenazine, which provided additional options for managing severe mental illness. These medications revolutionized psychiatry, shifting treatment from institutional care to outpatient settings and improving patient quality of life. While second-generation antipsychotics have largely replaced FGAs as first-line treatments, typical antipsychotics remain valuable for certain clinical scenarios. NiHowdy simplifies access to these effective medications, ensuring affordability for patients.

How do Typical Antipsychotics work?

Typical antipsychotics work by blocking dopamine D2 receptors in the brain, particularly in the mesolimbic pathway, which helps reduce symptoms of psychosis such as hallucinations and delusions. However, this mechanism can also affect other dopamine pathways, leading to side effects such as motor symptoms or sedation. For example, haloperidol is frequently used to manage acute psychotic episodes due to its strong dopamine receptor blockade, providing rapid symptom relief. NiHowdy ensures patients can access these targeted therapies affordably, supporting their mental health management.

What are Typical Antipsychotics used to treat?

Schizophrenia

Typical antipsychotics are primarily used to manage schizophrenia, particularly the positive symptoms such as hallucinations, delusions, and agitation. Medications like haloperidol and fluphenazine help stabilize mood and behavior, allowing patients to function better in daily life.

Bipolar Disorder (Manic Episodes)

In acute manic episodes associated with bipolar disorder, typical antipsychotics like chlorpromazine can rapidly reduce agitation, mood elevation, and hyperactivity, helping to stabilize the patient.

Acute Psychosis and Agitation

Typical antipsychotics are effective in managing acute psychosis and agitation, often used in emergency settings. Medications like haloperidol provide quick sedation and control over severe symptoms, improving patient safety.

Tourette Syndrome

In some cases, typical antipsychotics such as pimozide are prescribed to manage tics and vocal outbursts associated with Tourette syndrome, reducing the frequency and severity of these symptoms.

Who should consider Typical Antipsychotics medications?

Adults

Adults with psychotic disorders such as schizophrenia or acute manic episodes benefit significantly from typical antipsychotics. These medications provide rapid relief from positive symptoms, allowing patients to regain stability and functionality.

Children

Typical antipsychotics are used cautiously in pediatric populations, primarily for severe cases of psychosis or Tourette syndrome. Doses are carefully adjusted, and regular monitoring ensures safety and effectiveness.

Seniors

Seniors with psychotic symptoms or severe agitation may benefit from typical antipsychotics, but they require careful assessment due to increased sensitivity to side effects such as sedation and movement disorders. Healthcare providers tailor treatment to minimize risks and ensure safety.

Are Typical Antipsychotics safe?

Typical antipsychotics are generally safe when used as prescribed but can cause side effects. Common side effects include drowsiness, dry mouth, and constipation. More serious risks include extrapyramidal symptoms (EPS), tardive dyskinesia, and neuroleptic malignant syndrome. Regular monitoring and adherence to prescribed doses help ensure safe and effective treatment.

Can I take Typical Antipsychotics during pregnancy?

The use of typical antipsychotics during pregnancy should be carefully evaluated. While some medications may be used if the benefits outweigh the risks, others may pose potential risks to the developing fetus. Pregnant individuals should consult their healthcare provider for personalized guidance.

Are Typical Antipsychotics safe to take while lactating?

Certain typical antipsychotics may be used during breastfeeding with caution, as some may pass into breast milk in small amounts. Patients should consult their healthcare provider to determine the safest options and monitor for any adverse effects in the infant.

Are Typical Antipsychotics controlled substances?

Typical antipsychotics are not classified as controlled substances. They are available by prescription for managing conditions like schizophrenia and acute psychosis. Regular follow-ups with healthcare providers ensure proper use and monitoring.

Side effects of Typical Antipsychotics?

Typical antipsychotics are effective but may cause side effects. Common side effects include drowsiness, dry mouth, weight gain, and constipation. These effects are generally mild and improve with continued use or dose adjustments. Less common side effects include dizziness, blurred vision, and mild restlessness. Patients experiencing these symptoms should discuss them with their healthcare provider for potential adjustments to their treatment. Rare but serious side effects include extrapyramidal symptoms (e.g., muscle stiffness, tremors, or rigidity), tardive dyskinesia (involuntary movements), and neuroleptic malignant syndrome (a life-threatening reaction characterized by fever, muscle rigidity, and altered mental status). Immediate medical attention is required for severe symptoms. Healthcare providers recommend regular monitoring, including assessments for movement disorders and metabolic changes, to minimize risks and optimize the benefits of treatment. Adherence to prescribed regimens and open communication ensure safe and effective use.

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Cost considerations and insurance coverage for Typical Antipsychotics

Typical antipsychotics are widely available as affordable generic options, such as haloperidol and chlorpromazine. Most insurance plans cover these medications for approved indications, such as schizophrenia or acute psychosis. NiHowdy offers discounts, rebates, and Bitcoin rewards to further reduce costs, making these therapies accessible to all patients.

How do I get rebates on Typical Antipsychotics?

NiHowdy's Bitcoin rebate program for typical antipsychotics offers patients a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing psychotic disorders both affordable and rewarding, ensuring access to effective treatments while building long-term value.