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Perphenazine-Amitriptyline
Perphenazine-amitriptyline is a combination medication that combines perphenazine, an antipsychotic, with amitriptyline, a tricyclic antidepressant. This combination is used to treat various psychiatric disorders, particularly those involving anxiety and mood disturbances, as well as conditions like depression accompanied by psychotic features.
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Frequently Asked Questions
How quickly does perphenazine-amitriptyline work?
Patients may begin to notice improvements in their symptoms within 1 to 2 weeks, but it may take longer for the full effects to be realized.
Can I take perphenazine-amitriptyline with food?
Yes, it can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while using perphenazine-amitriptyline?
There are no specific dietary restrictions, but avoid alcohol.
Is perphenazine-amitriptyline safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using this medication during these periods.
Comprehensive Drug Guide
How Does Perphenazine-Amitriptyline Work?
- Perphenazine: Blocks dopamine D2 receptors, helping to reduce psychotic symptoms such as hallucinations and delusions.
- Amitriptyline: Inhibits the reuptake of norepinephrine and serotonin, which can help improve mood and alleviate depressive symptoms. The combination enhances the therapeutic effects on mood and anxiety while managing psychotic symptoms.
Common Dosages
Perphenazine-amitriptyline is typically available in the following dosage form:
- Tablets: Common combinations include 4 mg perphenazine with 12.5 mg amitriptyline.
Typical Dosing
- The usual starting dose may vary based on the condition being treated, but it often starts around 1 tablet taken 2 to 3 times daily, adjusted based on clinical response.
Typical Dosing
FDA Approved Indications
- Psychotic Depression: to treat depression with accompanying psychotic features.
- Severe Anxiety: in certain cases where an antidepressant and antipsychotic may be beneficial.
Who Shouldn't Take Perphenazine-Amitriptyline?
- Known hypersensitivity to either perphenazine or amitriptyline.
- Severe central nervous system depression or comatose states.
- Recent myocardial infarction (heart attack) or arrhythmias.
Advice From The Pharmacist
- Take the medication exactly as prescribed; do not stop taking it abruptly without consulting your healthcare provider to avoid withdrawal symptoms.
- Monitor for any side effects, particularly those related to mood or movement disorders, and report them to your healthcare provider.
- Avoid alcohol and other central nervous system depressants while using this medication.
Side Effects of Perphenazine-Amitriptyline
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Weight gain
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (e.g., tremors, rigidity)
- Neuroleptic Malignant Syndrome (NMS)
- Serotonin syndrome (especially with other serotonergic agents).
Risks and Warnings of Perphenazine-Amitriptyline
- Movement Disorders: Monitor for signs of extrapyramidal symptoms and report them immediately.
- NMS: Be aware of signs such as high fever, muscle rigidity, and altered mental status.
Interactions with Perphenazine-Amitriptyline
Common Drug Interactions
- Other Antidepressants: Avoid combining with other serotonergic agents due to the risk of serotonin syndrome.
- CNS Depressants: Use caution with other medications that may cause sedation.
Alternatives to Perphenazine-Amitriptyline
- Other Antipsychotics: Such as risperidone or quetiapine for managing psychotic features.
- Other Antidepressants: Such as SSRIs or SNRIs for managing depressive symptoms.
