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Perphenazine
Perphenazine is an antipsychotic medication primarily used to treat schizophrenia and other severe mental health conditions. It is also effective for managing symptoms of severe anxiety and agitation. As a typical antipsychotic, it works by helping to restore the balance of certain neurotransmitters in the brain.
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Frequently Asked Questions
How quickly does perphenazine work?
Patients may start to notice improvements in symptoms within 1 to 2 weeks, but it may take longer for the full therapeutic effects to be realized.
Can I take perphenazine with food?
Yes, it can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while using perphenazine?
There are no specific dietary restrictions while using perphenazine.
Is perphenazine safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using perphenazine during these periods.
Comprehensive Drug Guide
How Does Perphenazine Work?
Perphenazine primarily works by blocking dopamine D2 receptors in the brain. This action helps reduce psychotic symptoms such as hallucinations and delusions, as well as stabilizing mood and reducing agitation.
Common Dosages
Perphenazine is typically available in the following dosage forms:
- Tablets: Common strengths include 4 mg, 8 mg, and 16 mg.
- Injection: Available for intramuscular administration.
Typical Dosing
- The usual starting dose for adults is 8 mg to 16 mg daily, divided into two or three doses, with potential adjustments based on clinical response. The maximum recommended dose is 64 mg per day.
Typical Dosing
FDA Approved Indications
- Schizophrenia: for the treatment of schizophrenia in adults.
- Severe Anxiety: for the management of severe anxiety or agitation.
Who Shouldn't Take Perphenazine?
- Known hypersensitivity to perphenazine or any component of the formulation.
- Severe central nervous system depression.
- Coma.
Advice From The Pharmacist
- Take perphenazine exactly as prescribed and do not discontinue abruptly without consulting your healthcare provider, as this can lead to withdrawal symptoms.
- Regular monitoring for side effects and effectiveness is important, especially in the early stages of treatment.
- Avoid alcohol and other central nervous system depressants while using this medication.
Side Effects of Perphenazine
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Constipation
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (e.g., tremors, rigidity, restlessness)
- Neuroleptic Malignant Syndrome (NMS)
- Tardive dyskinesia (involuntary movements).
Risks and Warnings of Perphenazine
- Movement Disorders: Monitor for signs of extrapyramidal symptoms and report them to your healthcare provider immediately.
- NMS: A potentially life-threatening condition characterized by fever, muscle rigidity, and altered mental status.
Interactions with Perphenazine
Common Drug Interactions
- Other Antipsychotics: Use caution when combining with other antipsychotics due to increased risk of side effects.
- CNS Depressants: Caution is advised when used with other medications that cause sedation.
Alternatives to Perphenazine
- Other Antipsychotics: Such as risperidone or quetiapine for similar indications.
- Non-Pharmacological Approaches: Psychotherapy or cognitive behavioral therapy may also be beneficial in managing symptoms.
