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Compro
Compro (prochlorperazine) is a phenothiazine antipsychotic used to treat nausea, vomiting, and schizophrenia. It is also sometimes used to manage severe anxiety and other conditions where control of nausea and vomiting is necessary. Compro works by blocking dopamine receptors in the brain, which helps control symptoms.
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Frequently Asked Questions
How long does it take for Compro to work?
Compro typically starts working within 30 to 60 minutes after taking the oral tablet or suppository for nausea and vomiting.
Can I use Compro for long-term nausea control?
Compro is generally used for short-term management of nausea and vomiting. Long-term use may lead to serious side effects, such as tardive dyskinesia.
What should I do if I miss a dose of Compro?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Can Compro cause movement problems?
Yes, Compro can cause extrapyramidal symptoms and tardive dyskinesia, particularly with long-term use. Contact your healthcare provider if you experience any unusual muscle movements.
Is Compro safe during pregnancy?
Compro should be used during pregnancy only if clearly needed. Consult your healthcare provider about the risks and benefits.
Comprehensive Drug Guide
How Does Compro Work?
Compro works by blocking dopamine D2 receptors in the brain, which helps to reduce nausea, vomiting, and certain psychotic symptoms. This action affects the chemoreceptor trigger zone in the brain, which is responsible for inducing vomiting, and reduces dopamine’s influence on psychosis.
Common Dosages
- Suppositories: 25 mg
- Tablets: 5 mg, 10 mg
Typical Dosing
- For nausea and vomiting: The usual dose is 5 to 10 mg orally three to four times a day, or 25 mg by suppository every 12 hours, as needed.
- For schizophrenia: The dose is typically 10 mg three to four times daily, with adjustments based on clinical response.
Typical Dosing
FDA Approved Indications
- Severe nausea and vomiting
- Schizophrenia
- Severe anxiety (short-term use)
Who Shouldn't Take Compro?
- Known hypersensitivity to prochlorperazine or other phenothiazines.
- Severe central nervous system depression (e.g., coma).
- Bone marrow suppression or severe liver disease.
Advice From The Pharmacist
- For suppositories, remove the outer packaging before insertion. Insert the suppository rectally, and remain lying down for a few minutes to allow absorption.
- Avoid driving or operating heavy machinery until you know how Compro affects you, as it can cause drowsiness or dizziness.
- Do not drink alcohol while using Compro, as it can increase the risk of side effects like drowsiness.
Side Effects of Compro
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Constipation
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (EPS), such as muscle stiffness, tremors, or difficulty walking.
- Tardive dyskinesia (involuntary muscle movements), especially with long-term use.
- Severe allergic reactions (rash, swelling, difficulty breathing).
Risks and Warnings of Compro
- Extrapyramidal Symptoms: Compro can cause movement disorders, including tremors, muscle rigidity, and restlessness. If these occur, contact your healthcare provider immediately.
- Tardive Dyskinesia: Long-term use of Compro can lead to involuntary muscle movements, which may be permanent.
- Neuroleptic Malignant Syndrome: Rarely, Compro can cause a life-threatening condition called neuroleptic malignant syndrome, characterized by fever, muscle rigidity, and altered mental status.
Interactions with Compro
Common Drug Interactions
- CNS depressants: Using Compro with other central nervous system depressants (e.g., alcohol, sedatives, opioids) can increase the risk of sedation and respiratory depression.
- Anticholinergics: Concurrent use with anticholinergic medications can increase the risk of constipation, dry mouth, and urinary retention.
- Antihypertensive medications: Combining Compro with blood pressure-lowering medications can increase the risk of low blood pressure.
Alternatives to Compro
- Zofran (ondansetron): A serotonin antagonist used to treat nausea and vomiting, particularly in chemotherapy and postoperative patients.
- Phenergan (promethazine): Another phenothiazine used to treat nausea, vomiting, and motion sickness.
- Reglan (metoclopramide): A medication used to treat nausea, vomiting, and gastroparesis, with prokinetic effects.
