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Ondansetron
Ondansetron is an antiemetic medication commonly known for its effectiveness against nausea and vomiting, symptoms which are often associated with surgery, chemotherapy, and radiation therapy.
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Frequently Asked Questions
Can I take ondansetron if I'm pregnant or planning to become pregnant?
You should discuss this with your healthcare provider. The risk of developing a major congenital malformation following first trimester exposure is under study.
Can I drink alcohol while on ondansetron?
It's best to avoid alcohol. Although ondansetron can help with nausea, alcohol can negate its effects and may even make nausea symptoms worse.
I missed a dose of ondansetron. What should I do?
If you remember soon after the missed dose, take it as soon as possible. However, if it's nearly time for your next dose, skip it and continue with your regular dosing schedule.
Can I stop taking ondansetron as soon as I start feeling better?
Always follow your healthcare provider's instructions. In some cases, you might need to complete the treatment course despite feeling better, to ensure the best results.
Comprehensive Drug Guide
How Does Ondansetron Work?
Ondansetron is a selective 5-HT3 receptor antagonist. It blocks the action of serotonin, a natural substance that can trigger nausea and vomiting.
What is Ondansetron Used For?
Ondansetron is used primarily to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery.
Off-label it has been used for drug-induced nausea and vomiting, panic disorder, multiple sclerosis nausea, and gastroenteritis vomiting.
Common Dosages
Ondansetron is most commonly manufactured in the following formulations:
Tablets: 4mg, 8mg, 24mg
Oral disintegrating tablets: 4mg, 8mg
Oral solution: 4mg/5mL
Typical Dosing
FDA Approved Indications
- Prevention of postoperative nausea/vomiting: 16mg, 1 hour before anesthesia induction.
- Radiation-induced nausea and vomiting: 8mg 1-2 hours prior to each fraction of radiotherapy, then 8 mg every 12 hours for 1 to 2 days post-chemotherapy
Off-Label Uses
- Drug induced nausea and vomiting: 8-16 mg IV once daily.
- Multiple sclerosis nausea: 8mg orally twice daily.
Who Shouldn't Take Ondansetron?
- Those with a history of irregular heart rhythm or Long QT Syndrome.
- Those with severe liver disease.
- Those with phenylketonuria because it contains phenylalanine.
Advice From The Pharmacist
- Possible side effects include headaches, lightheadedness, constipation, and rarely, chest pain or slow heart rate. Reach out to your healthcare provider if you notice such symptoms.
- Let your healthcare provider know about all medications you are currently taking, to avoid possible drug interactions.
- Do not drive or operate heavy machinery if you feel dizzy or lightheaded.
Side Effects of Ondansetron
Common Side Effects
- You may feel a bit dizzy or tired.
- A headache might bug you.
- You may feel a bit constipated.
- You might notice your mouth is a bit dry.
Uncommon/Severe Side Effects
- You might have irregular heart rhythms, which can be life-threatening.
- You may feel light-headed due to low blood pressure (hypotension).
Risks and Warnings of Ondansetron
- Avoid taking ondansetron if you're on apomorphine due to severe interactions.
- Side effects like headache, lightheadedness, or dizziness are telltale signs of a dose gone wrong.
Interactions with Ondansetron
Common Drug Interactions
- Certain pain medications (controlled substances like tramadol)
- Medicine for depression and mental illnesses (such as SSRIs, SNRIs, and MAOIs)
- Other medications for nausea or vomiting (like promethazine and prochlorperazine)
Alternatives to Ondansetron
- Granisetron
- Dolasetron
- Promethazine
- Prochlorperazine
- Metoclopramide
