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Reglan
Reglan (metoclopramide) is a medication primarily used to treat nausea and vomiting, as well as to facilitate gastric emptying in patients with gastroparesis. It is particularly effective for managing nausea related to chemotherapy, postoperative recovery, or conditions affecting the stomach. Metoclopramide acts as a prokinetic agent and antiemetic, enhancing gastrointestinal motility and blocking dopamine receptors in the brain that trigger nausea.
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Frequently Asked Questions
How quickly does Reglan start working?
Metoclopramide typically starts to relieve nausea and vomiting within 30 to 60 minutes of administration.
Can I stop taking Reglan suddenly?
It is advisable to consult your healthcare provider before discontinuing Reglan, especially if you have been using it long-term, to avoid potential withdrawal symptoms.
Are there any dietary restrictions while taking Reglan?
There are no specific dietary restrictions, but it may be helpful to maintain a balanced diet to support gastrointestinal health.
What should I do if I miss a dose of Reglan?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Reglan safe for long-term use?
Long-term use of Reglan should be regularly evaluated by a healthcare provider to assess benefits and risks, particularly concerning the potential for movement disorders.
Comprehensive Drug Guide
How Does Reglan Work?
Metoclopramide works by blocking dopamine D2 receptors in the brain, which reduces nausea and vomiting. It also enhances the motility of the upper gastrointestinal tract by increasing peristalsis and gastric emptying, thereby improving the movement of food through the stomach and intestines.
Common Dosages
- Tablets: 5 mg and 10 mg
- Orally disintegrating tablets: 5 mg and 10 mg
- Injectable solution: 5 mg/mL
Typical Dosing
- For nausea and vomiting: The typical oral dose for adults is 10 mg taken 30 minutes before meals and at bedtime, up to four times daily.
- For gastroparesis: The usual dose is 10 mg taken 30 minutes before meals and at bedtime, similar to the dosing for nausea.
Typical Dosing
FDA Approved Indications
- Prevention of nausea and vomiting associated with chemotherapy and surgery
- Treatment of gastroparesis in diabetic patients
- Facilitation of gastric emptying in patients with certain gastrointestinal disorders
Who Shouldn't Take Reglan?
- Known hypersensitivity to metoclopramide or any of its components
- Gastrointestinal obstruction, perforation, or hemorrhage
- History of tardive dyskinesia or other movement disorders
Advice From The Pharmacist
- Take Reglan exactly as prescribed, and do not exceed the recommended dosage to minimize the risk of side effects.
- Be cautious when driving or operating heavy machinery until you know how Reglan affects you, as it can cause drowsiness.
- Inform your healthcare provider about any other medications you are taking, as there may be interactions.
Side Effects of Reglan
Common Side Effects
- Drowsiness or sedation
- Fatigue
- Nausea
- Diarrhea
Uncommon/Severe Side Effects
- Tardive dyskinesia (a serious movement disorder)
- Neuroleptic malignant syndrome (a rare but life-threatening reaction)
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
Risks and Warnings of Reglan
- Movement Disorders: Prolonged use of metoclopramide can lead to tardive dyskinesia, especially in elderly patients or those on long-term therapy. Regular monitoring is essential.
- CNS Effects: Monitor for symptoms of excessive sedation or changes in mental status, especially when used in combination with other CNS depressants.
- Pregnancy and Lactation: Discuss the use of Reglan during pregnancy or while breastfeeding with your healthcare provider to ensure safety and appropriateness.
Interactions with Reglan
Common Drug Interactions
- CNS Depressants: Be cautious when using Reglan with other sedatives or alcohol, as they may enhance the sedative effects.
- Anticholinergic Drugs: Concurrent use may reduce the effectiveness of metoclopramide.
- Digoxin: Metoclopramide may affect the absorption of digoxin, necessitating monitoring of digoxin levels.
Alternatives to Reglan
- Other Antiemetics: Such as ondansetron or prochlorperazine for managing nausea and vomiting.
- Prokinetic Agents: Such as erythromycin or other medications for gastrointestinal motility disorders.
