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Adasuve
Adasuve (generic name: loxapine) is an inhaled antipsychotic medication used to treat acute agitation associated with schizophrenia and bipolar I disorder in adults. It is a typical antipsychotic that works by modulating neurotransmitters in the brain, particularly dopamine and serotonin, helping to quickly reduce agitation and aggressive behavior. Adasuve is unique in its inhaled formulation, providing rapid relief of symptoms in patients experiencing severe agitation.
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Frequently Asked Questions
How quickly does Adasuve work?
Adasuve typically begins to take effect within 10 minutes of inhalation, providing rapid relief from acute agitation.
Can I take Adasuve at home?
No, Adasuve is only administered in a healthcare setting due to the risk of serious side effects, including bronchospasm, which requires monitoring after administration.
Is Adasuve safe for people with asthma?
No, Adasuve is contraindicated in individuals with asthma or any other respiratory condition, as it can cause severe bronchospasm.
What should I do if I experience difficulty breathing after using Adasuve?
If you experience any difficulty breathing or signs of bronchospasm after using Adasuve, seek immediate medical attention. This is why the medication is only administered in a healthcare setting where emergency care is available.
How often can Adasuve be used?
Adasuve is typically administered as a single dose during an episode of acute agitation. Repeated doses are not generally recommended due to the risk of side effects.
Comprehensive Drug Guide
How Does Adasuve Work?
Adasuve works by blocking dopamine D2 receptors and serotonin 5-HT2 receptors in the brain. By reducing the activity of these neurotransmitters, Adasuve helps decrease the agitation and aggressive behavior associated with acute psychosis or manic episodes. The inhaled form allows the medication to be absorbed quickly through the lungs, providing rapid onset of action, usually within 10 minutes.
Common Dosages
- Inhalation powder: 10 mg (single-use device)
Typical Dosing
- The recommended dose for acute agitation is 10 mg, administered via inhalation. The medication is delivered through a single-use inhaler, and only one dose is typically given during an episode of agitation.
- Additional doses are not usually recommended, as Adasuve is meant for acute, short-term management.
Typical Dosing
FDA Approved Indications
- The treatment of acute agitation in patients with schizophrenia or bipolar I disorder.
Who Shouldn't Take Adasuve?
- Known hypersensitivity to loxapine or any of the ingredients in Adasuve
- Chronic obstructive pulmonary disease (COPD), asthma, or any other acute or chronic respiratory conditions
- Acute respiratory distress or risk of bronchospasm
Advice From The Pharmacist
- Adasuve should only be administered in a healthcare facility where patients can be monitored for potential respiratory issues, particularly bronchospasm.
- Inhalation is the only approved route of administration for this medication. It is not available in oral or injectable forms.
- After administration, patients should be observed for at least one hour for signs of bronchospasm or respiratory distress.
- Patients with a history of asthma or respiratory conditions should not use Adasuve due to the risk of severe bronchospasm.
Side Effects of Adasuve
Common Side Effects
- Sedation or drowsiness
- Dizziness
- Dysgeusia (altered taste sensation)
Uncommon/Severe Side Effects
- Bronchospasm, which can be life-threatening in individuals with respiratory conditions
- Acute respiratory distress
- Severe allergic reactions (such as anaphylaxis)
Risks and Warnings of Adasuve
- Bronchospasm Risk: Adasuve carries a risk of bronchospasm, which can lead to respiratory distress. This is why the medication is only administered in a supervised healthcare setting where emergency care is available.
- Sedation: Patients may experience drowsiness or sedation after inhaling Adasuve, which could affect their ability to perform tasks that require alertness, such as driving.
- Respiratory Monitoring: Continuous monitoring for at least one hour post-administration is essential, particularly for signs of breathing difficulty or bronchospasm.
Interactions with Adasuve
Common Drug Interactions
- Central nervous system depressants: Combining Adasuve with medications that depress the central nervous system, such as benzodiazepines or opioids, may increase the risk of sedation or respiratory depression.
- Anticholinergic medications: These may exacerbate the side effects of Adasuve, including dry mouth, dizziness, and urinary retention.
Alternatives to Adasuve
- Haloperidol: A first-generation antipsychotic often used for acute agitation, available in injectable or oral forms.
- Olanzapine (Zyprexa): An atypical antipsychotic available in oral, injectable, and dissolvable forms for treating acute agitation in schizophrenia or bipolar disorder.
- Risperidone: Another atypical antipsychotic used to manage agitation in patients with schizophrenia or bipolar disorder, available in oral or injectable forms.
