NiHowdy > Drug Classes > Topical Antifungals

Browse Medications by Drug Class: Topical Antifungals

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Updated Jan 24, 2025

•

Published Jan 15, 2025

Fact checked

What are Topical Antifungals?

Topical antifungals are medications applied directly to the skin, nails, or mucous membranes to treat fungal infections. These treatments work by targeting and disrupting the structure or function of fungal cells, thereby stopping their growth or killing them outright. Commonly used to treat conditions like athlete's foot, ringworm, and yeast infections, topical antifungals offer a localized treatment approach with minimal systemic side effects. A unique feature of these medications is their ability to provide effective relief while maintaining a targeted application, ensuring minimal interference with overall health. NiHowdy ensures affordable access to these essential therapies, supporting patients in managing fungal infections effectively.

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List of drugs in Topical Antifungals

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Benzoic Acid	Benzoic Acid Information	Benzoic Acid Pricing
Ciclopirox	Ciclopirox Information	Ciclopirox Pricing
Ciclopirox Olamine	Ciclopirox Olamine Information	Ciclopirox Olamine Pricing
Dermetazole	Dermetazole Information	Dermetazole Pricing
Econazole Nitrate	Econazole Nitrate Information	Econazole Nitrate Pricing
Ecoza	Ecoza Information	Ecoza Pricing
Ertaczo	Ertaczo Information	Ertaczo Pricing
Exelderm	Exelderm Information	Exelderm Pricing
Extina	Extina Information	Extina Pricing
Jublia	Jublia Information	Jublia Pricing
Ketoconazole	Ketoconazole Information	Ketoconazole Pricing
Ketodan	Ketodan Information	Ketodan Pricing
Loprox	Loprox Information	Loprox Pricing
Luliconazole	Luliconazole Information	Luliconazole Pricing
Luzu	Luzu Information	Luzu Pricing
Mentax	Mentax Information	Mentax Pricing
Naftifine HCl	Naftifine HCl Information	Naftifine HCl Pricing
Naftin	Naftin Information	Naftin Pricing
Oxiconazole Nitrate	Oxiconazole Nitrate Information	Oxiconazole Nitrate Pricing
Oxistat	Oxistat Information	Oxistat Pricing
Rimi	Rimi Information	Rimi Pricing
Selenium Sulfide	Selenium Sulfide Information	Selenium Sulfide Pricing
SelRx	SelRx Information	SelRx Pricing
Sulconazole Nitrate	Sulconazole Nitrate Information	Sulconazole Nitrate Pricing
Xolegel	Xolegel Information	Xolegel Pricing

Brief history about Topical Antifungals?

The development of topical antifungals began in the mid-20th century, with early treatments like tolnaftate and clotrimazole revolutionizing the management of superficial fungal infections. Over time, newer agents such as ketoconazole, terbinafine, and ciclopirox expanded the therapeutic arsenal, offering enhanced efficacy and broader antifungal coverage. These advancements have made topical antifungals the cornerstone of fungal infection treatment, providing patients with safe and effective options for localized therapy. NiHowdy simplifies access to these medications, ensuring affordability for patients.

How do Topical Antifungals work?

Topical antifungals work by disrupting the cell membranes or metabolic processes of fungi, inhibiting their growth or killing them. For example: ^ Azoles (e.g., clotrimazole, ketoconazole): Inhibit ergosterol synthesis, a critical component of fungal cell membranes, leading to cell death. ^ Allylamines (e.g., terbinafine): Block the synthesis of squalene epoxidase, disrupting fungal cell membrane integrity. ^ Polyene Antifungals (e.g., nystatin): Bind to ergosterol, creating pores in the fungal cell membrane and causing cell leakage. ^ Other Agents (e.g., ciclopirox): Target fungal enzymes or disrupt their metabolic pathways. These mechanisms ensure effective treatment while minimizing systemic absorption, making them safe for most patients. NiHowdy ensures affordable access to these targeted therapies, improving patient outcomes in managing fungal infections.

What are Topical Antifungals used to treat?

Athlete's Foot (Tinea Pedis)

Topical antifungals like terbinafine and clotrimazole are first-line treatments for athlete's foot, addressing symptoms such as itching, scaling, and redness. These medications penetrate the skin to eliminate the underlying fungal infection, providing relief within days to weeks.

Ringworm (Tinea Corporis)

Ringworm, a common fungal skin infection, responds well to azoles and allylamines. These topical agents target the fungus directly, reducing inflammation and preventing the spread of infection.

Jock Itch (Tinea Cruris)

Topical antifungals like miconazole and terbinafine are effective in managing jock itch, alleviating discomfort and irritation caused by fungal growth in warm, moist areas of the body.

Yeast Infections (Cutaneous Candidiasis)

Yeast infections caused by Candida species are treated with topical azoles like clotrimazole and nystatin. These medications reduce fungal overgrowth and relieve associated symptoms, such as redness and itching.

Nail Fungus (Onychomycosis)

Topical antifungals such as ciclopirox and efinaconazole are used to treat fungal infections of the nails. While slower acting than oral treatments, they are effective in mild to moderate cases and provide a non-systemic option for patients.

Who should consider Topical Antifungals medications?

Adults

Adults with superficial fungal infections, including athlete's foot, jock itch, and ringworm, benefit from topical antifungal medications. These treatments provide targeted relief without significant systemic effects, making them suitable for a wide range of patients.

Children

Topical antifungals are safe and effective for children with fungal infections, particularly for conditions like ringworm or athlete's foot. Pediatric formulations and dosing ensure effective treatment while minimizing irritation.

Seniors

Seniors with fungal infections, especially nail fungus or candidiasis, can benefit from topical antifungals. These medications provide localized treatment with minimal drug interactions, which is important for individuals managing multiple health conditions.

Are Topical Antifungals safe?

Topical antifungals are generally safe and well-tolerated when used as directed. Common side effects include mild skin irritation, redness, or burning at the application site, which are usually temporary. Rare but serious risks include allergic reactions or worsening of symptoms, requiring immediate medical attention. Regular use as prescribed ensures effective treatment while minimizing side effects.

Can I take Topical Antifungals during pregnancy?

Many topical antifungals, such as clotrimazole and miconazole, are considered safe for use during pregnancy when applied as directed. Pregnant individuals should consult their healthcare provider to confirm the safety of specific treatments for their condition.

Are Topical Antifungals safe to take while lactating?

Topical antifungals are generally safe to use while breastfeeding, as systemic absorption is minimal. Lactating individuals should avoid applying these medications to areas that may come into direct contact with the infant, such as the breasts, without consulting a healthcare provider.

Are Topical Antifungals controlled substances?

Topical antifungals are not classified as controlled substances. They are widely available over the counter or by prescription, depending on the formulation and strength, ensuring accessibility for managing fungal infections.

Side effects of Topical Antifungals?

Topical antifungals are effective but may cause side effects. Common side effects include mild irritation, redness, or itching at the application site. These symptoms are typically short-lived and resolve as the skin adapts to treatment. Less common side effects include dryness, peeling, or slight discoloration of the treated area. Adjustments to the application frequency or the use of a soothing moisturizer can alleviate these effects. Rare but serious side effects include severe allergic reactions, such as swelling, rash, or difficulty breathing. Patients experiencing these symptoms should seek immediate medical attention. Rarely, worsening of symptoms may occur due to incorrect use or an underlying condition requiring further evaluation. Healthcare providers recommend using topical antifungals exactly as prescribed and monitoring for any adverse reactions. Proper application and adherence to the treatment regimen ensure effective results while minimizing side effects.

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Cost considerations and insurance coverage for Topical Antifungals

The cost of topical antifungals varies based on the medication and whether it is over-the-counter or prescription. Generic options like clotrimazole and terbinafine are affordable, while prescription treatments may be more expensive. Most insurance plans cover prescription antifungals for fungal infections. NiHowdy offers discounts, rebates, and Bitcoin rewards to make these treatments accessible and cost-effective.

How do I get rebates on Topical Antifungals?

NiHowdy's Bitcoin rebate program for topical antifungals provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing fungal infections both affordable and rewarding, ensuring access to effective treatments while building long-term value.

Therapeutic Classes linked to Topical Antifungals

Dermatological Agents (Skin Disorders)

Medical Conditions treated by Topical Antifungals

A

Acne

Y

Yeast Infections (Candidiasis)