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Naftifine HCl

Naftifine HCl is an antifungal medication used primarily to treat superficial fungal infections, including tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). It belongs to the class of allylamine antifungals and works by inhibiting fungal growth.



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Frequently Asked Questions

How quickly does naftifine HCl work?
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Patients may start to notice improvements within a few days of treatment, but it is important to complete the full course to ensure the infection is fully cleared.

Can I use naftifine HCl with other skin products?
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Yes, but it’s best to apply naftifine first, and wait for it to dry before applying other topical products.

What should I do if I miss a dose?
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If you miss a dose, apply it as soon as you remember. If it's close to the time for your next application, skip the missed dose and continue with your regular schedule.

Are there any dietary restrictions while using naftifine HCl?
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There are no specific dietary restrictions while using naftifine.

Is naftifine HCl safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using naftifine HCl.

Comprehensive Drug Guide

How Does Naftifine HCl Work?

Naftifine works by inhibiting the enzyme squalene epoxidase, which is crucial for the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to increased permeability of the fungal cell membrane, ultimately resulting in cell death.



Common Dosages

  • Topical Cream: 1% formulation.
  • Gel: 1% formulation.

Typical Dosing

  • For topical use, apply a thin layer of naftifine cream or gel to the affected area once daily, usually for 2 to 4 weeks, depending on the severity of the infection.


Typical Dosing

FDA Approved Indications

  • Tinea Pedis: for the treatment of an athlete's foot.
  • Tinea Cruris: for the treatment of jock itch.
  • Tinea Corporis: for the treatment of ringworm.


Who Shouldn't Take Naftifine HCl?

  • Known hypersensitivity to naftifine or any component of the formulation.
  • Open wounds or on mucous membranes.


Advice From The Pharmacist

  • Apply naftifine as directed, ensuring the affected area is clean and dry before application.
  • Continue treatment for the full prescribed duration, even if symptoms improve, to prevent recurrence of the infection.
  • Avoid covering the treated area with airtight dressings unless directed by a healthcare provider.


Side Effects of Naftifine HCl

Common Side Effects

  • Localized skin irritation
  • Burning or stinging sensation at the application site
  • Rash or redness


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, itching, swelling)
  • Signs of infection (increased redness, swelling, or pus).


Risks and Warnings of Naftifine HCl

  • Skin Reactions: Monitor for any signs of allergic reactions or worsening skin conditions; discontinue use and seek medical attention if they occur.
  • Avoid Eye Contact: Naftifine should not come into contact with the eyes; rinse thoroughly with water if accidental contact occurs.


Interactions with Naftifine HCl

Common Drug Interactions

  • Other Topical Agents: Use caution when applying naftifine in conjunction with other topical medications to avoid irritation.


Alternatives to Naftifine HCl

  • Other Antifungal Medications: Such as terbinafine or clotrimazole for similar fungal infections.
  • Oral Antifungals: For more severe or extensive fungal infections, systemic treatment may be necessary.