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Xolegel
Xolegel (generic name: ketoconazole) is a topical antifungal gel used to treat seborrheic dermatitis, a common skin condition that causes redness, scaling, and dandruff-like flaking, particularly on the scalp, face, and chest. Ketoconazole, the active ingredient in Xolegel, works by inhibiting the growth of fungi and yeasts, which contribute to the inflammation and symptoms of seborrheic dermatitis.
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Frequently Asked Questions
How long does it take for Xolegel to start working?
You may start noticing improvements in seborrheic dermatitis symptoms within a few days to a week, but full resolution may take up to 2 weeks. Continue using the gel as prescribed, even if symptoms improve before the treatment period ends.
Can I use Xolegel on my scalp?
Yes, Xolegel is commonly used to treat seborrheic dermatitis on the scalp. Apply it to the affected areas as directed by your healthcare provider.
What should I do if I miss a dose of Xolegel?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up to make up for a missed dose.
Is Xolegel safe for long-term use?
Xolegel is generally prescribed for short-term use (up to 2 weeks). Prolonged use without medical supervision can lead to skin irritation or decreased effectiveness of the medication. Always follow your healthcare provider’s instructions.
Can I use Xolegel for other fungal infections?
Xolegel is specifically indicated for seborrheic dermatitis. For other fungal infections, your healthcare provider may prescribe different formulations of ketoconazole or other antifungals. Always consult your healthcare provider for appropriate treatment.
Comprehensive Drug Guide
How Does Xolegel Work?
Ketoconazole in Xolegel works by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting the cell membrane, ketoconazole weakens the fungus, preventing its growth and leading to the resolution of seborrheic dermatitis symptoms.
Common Dosages
- Ketoconazole 2% topical gel
Typical Dosing
- Apply a thin layer of Xolegel to the affected areas of the skin once daily for 2 weeks. The duration of treatment may vary based on the severity of the condition and the healthcare provider’s recommendations.
Typical Dosing
FDA Approved Indications
- Treatment of seborrheic dermatitis in immunocompetent adults and adolescents.
Who Shouldn't Take Xolegel?
- Known hypersensitivity to ketoconazole or any components of the formulation.
Advice From The Pharmacist
- Clean and dry the affected area before applying Xolegel. Apply a thin layer of the gel and gently rub it in.
- Avoid contact with the eyes, mouth, and mucous membranes. If the gel comes into contact with these areas, rinse thoroughly with water.
- Xolegel is for external use only. Do not use it on broken or irritated skin unless directed by your healthcare provider.
- Do not cover the treated area with occlusive dressings unless instructed by your healthcare provider, as this may increase the risk of side effects.
Side Effects of Xolegel
Common Side Effects
- Itching
- Burning sensation at the application site
- Redness
- Dryness
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Blistering or crusting at the application site
Risks and Warnings of Xolegel
- Allergic Reactions: Some individuals may experience allergic reactions to ketoconazole. Discontinue use and consult your healthcare provider if you notice signs of an allergic reaction, such as rash, swelling, or difficulty breathing.
- Long-Term Use: Avoid prolonged use of Xolegel without medical supervision, as long-term application of topical antifungals can increase the risk of skin irritation or sensitization.
Interactions with Xolegel
Common Drug Interactions
- Other topical products: Avoid using other topical products (e.g., corticosteroids, moisturizers) on the same areas as Xolegel unless instructed by your healthcare provider, as this may affect the efficacy of the treatment or increase the risk of skin irritation.
Alternatives to Xolegel
- Selenium sulfide (Selsun): Another topical treatment for seborrheic dermatitis that works by slowing the growth of fungi and skin cells.
- Ciclopirox (Loprox): A topical antifungal used to treat seborrheic dermatitis and other fungal skin infections.
- Hydrocortisone: A mild topical corticosteroid that can be used alongside antifungals to reduce inflammation and itching in seborrheic dermatitis.
