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Oxistat

Oxistat, the brand name for oxiconazole, is an antifungal medication used primarily for the topical treatment of tinea (ringworm) infections and other superficial fungal infections, including athlete's foot and jock itch. Oxistat works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting the growth and replication of the fungi responsible for these infections.

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Frequently Asked Questions

How long does it take for Oxistat to work?
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Many patients notice improvement within 1 to 2 weeks, but it is essential to continue treatment for at least 2 weeks after symptoms resolve to ensure complete elimination of the infection.

Can I use Oxistat on my face?
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Oxistat is typically intended for use on the body and should be used cautiously on the face. Consult your healthcare provider before applying it to facial areas.

What should I do if I miss a dose of Oxistat?
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If you miss an application, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Is Oxistat safe to use during pregnancy?
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While there is limited data on the use of Oxistat during pregnancy, topical antifungals are generally considered safe. However, consult your healthcare provider before use during pregnancy.

Can I use Oxistat if I have a skin infection?
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Oxistat is designed for fungal infections and should not be used for bacterial or viral skin infections. If you suspect a skin infection, consult your healthcare provider for appropriate treatment.

Comprehensive Drug Guide

How Does Oxistat Work?

Oxistat (oxiconazole) exerts its antifungal effect by inhibiting the enzyme 14α-demethylase, which is crucial for the synthesis of ergosterol in the fungal cell membrane. By disrupting ergosterol production, Oxistat alters the integrity of the fungal cell membrane, leading to cell death and ultimately resolving the infection.

Common Dosages

  • Oxistat cream: Typically contains 1% oxiconazole.
  • Oxistat solution: Typically contains 1% oxiconazole.

Typical Dosing

  • For most superficial fungal infections, apply Oxistat to the affected area once or twice daily as directed by your healthcare provider.
  • Continue using the medication for at least 2 weeks after symptoms improve to ensure the infection is completely resolved.

Typical Dosing

FDA Approved Indications

  • Topical treatment of tinea corporis (ringworm of the body).
  • Tinea pedis (athlete's foot).
  • Tinea cruris (jock itch).

Who Shouldn't Take Oxistat?

  • Known hypersensitivity to oxiconazole or any of the components of the formulation.
  • Open wounds or severe skin conditions, unless directed by a healthcare provider.

Advice From The Pharmacist

  • Apply a thin layer of Oxistat cream or solution to the affected area and rub it in gently.
  • Wash your hands before and after applying the medication to prevent the spread of infection.
  • Do not cover the treated area with a bandage unless directed by your healthcare provider.
  • Avoid using other topical products on the same area unless directed, as they may interfere with the effectiveness of Oxistat.

Side Effects of Oxistat

Common Side Effects

  • Localized skin irritation
  • Redness or burning sensation at the application site
  • Dryness or peeling of the skin

Uncommon/Severe Side Effects

  • Severe allergic reactions: Symptoms may include rash, itching, swelling, or difficulty breathing. Seek medical attention immediately if these occur.

Risks and Warnings of Oxistat

  • Skin reactions: If irritation or a rash develops that worsens or does not improve after a few days of treatment, discontinue use and consult your healthcare provider.
  • Infection recurrence: Superficial fungal infections may recur, especially if underlying conditions (like diabetes or a weakened immune system) are present. Addressing these factors may be necessary for effective treatment.

Interactions with Oxistat

Common Drug Interactions

  • Other topical antifungals: Caution should be exercised when using other antifungal products concurrently on the same area of skin, as this may interfere with treatment effectiveness.
  • Other topical medications: Always consult your healthcare provider before using other topical medications to avoid potential interactions.

Alternatives to Oxistat

  • Clotrimazole: Another topical antifungal commonly used to treat similar fungal infections.
  • Terbinafine: Available as both topical and oral formulations for treating fungal infections.
  • Miconazole: Another effective topical antifungal for treating skin infections.