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Ketodan

Ketodan, the brand name for ketoconazole, is an antifungal medication used primarily to treat various fungal infections. It is effective against a wide range of fungi, including those that cause skin infections, nail infections, and systemic infections. Ketodan is also used in some cases for dandruff and seborrheic dermatitis due to its ability to reduce fungal growth on the skin and scalp.

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Frequently Asked Questions

How long does it take for Ketodan to work?
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Ketodan may start to improve fungal infections within a few days, but it is important to complete the full course of treatment as directed to ensure the infection is fully resolved.

Can I use Ketodan with other skin products?
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You should wait until Ketodan has dried before applying other topical products to the same area. Inform your healthcare provider about all products you are using.

What should I do if I miss a dose of Ketodan?
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If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next application, skip the missed dose and return to your regular schedule. Do not double up on doses.

Can Ketodan be used during pregnancy?
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Topical ketoconazole is generally considered safer, but oral ketoconazole is contraindicated in pregnancy due to potential risks. Consult your healthcare provider if you are pregnant or planning to become pregnant.

Is Ketodan effective for all types of fungal infections?
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While Ketodan is effective against many fungal infections, its efficacy may vary based on the type of fungus. Your healthcare provider will determine the best treatment option based on the specific infection.

Comprehensive Drug Guide

How Does Ketodan Work?

Ketoconazole works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting the formation of ergosterol, ketoconazole compromises the integrity of the fungal cell membrane, leading to cell death. This mechanism is effective against a variety of fungi, including Candida species, Dermatophytes, and Malassezia.

Common Dosages

  • Topical cream or gel: Apply to the affected area once or twice daily.
  • Shampoo: Typically used once daily for 2 to 4 weeks for dandruff and seborrheic dermatitis.
  • Oral tablets: The usual dose for systemic infections is 200 mg once daily, but this can vary based on the specific infection.

Typical Dosing

  • For fungal skin infections: Apply the cream or gel to the affected area once daily for 2 to 4 weeks.
  • For dandruff: Use the shampoo twice a week for 4 weeks. For maintenance, it may be used once weekly.
  • For systemic infections: Oral tablets are typically dosed at 200 mg daily, depending on the severity and type of infection.

Typical Dosing

FDA Approved Indications

  • Treatment of dermatophyte infections (e.g., tinea corporis, tinea pedis, tinea cruris)
  • Candidiasis (cutaneous candidiasis)
  • Seborrheic dermatitis
  • Dandruff
  • Systemic fungal infections (oral tablets)

Who Shouldn't Take Ketodan?

  • Known hypersensitivity or allergy to ketoconazole or any components of the formulation.
  • Pregnancy: Oral ketoconazole is contraindicated in pregnancy due to potential teratogenic effects.
  • Concomitant use with certain medications that can prolong the QT interval (e.g., some antiarrhythmics).

Advice From The Pharmacist

  • Follow the prescribed application instructions closely to ensure effectiveness.
  • For topical formulations, clean and dry the affected area before applying the medication. Apply a thin layer and gently rub it in.
  • Avoid contact with the eyes and mucous membranes. If contact occurs, rinse thoroughly with water.
  • For oral use, take ketoconazole with food to enhance absorption. Do not take it on an empty stomach.
  • Store Ketodan at room temperature and keep it out of reach of children.

Side Effects of Ketodan

Common Side Effects

  • Skin irritation (topical use)
  • Itching or burning sensation at the application site
  • Nausea (oral use)
  • Headache
  • Dizziness

Uncommon/Severe Side Effects

  • Liver toxicity: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.
  • Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
  • Hormonal effects (due to systemic absorption from oral tablets), which can lead to gynecomastia or menstrual irregularities.

Risks and Warnings of Ketodan

  • Liver Function: Regular monitoring of liver function tests is recommended, especially for patients on oral ketoconazole, due to the risk of hepatotoxicity.
  • Drug Interactions: Ketoconazole can interact with many medications, affecting their metabolism. Patients should inform their healthcare provider of all medications they are taking.
  • Prolonged QT Interval: Use caution in patients with a history of cardiovascular issues, as ketoconazole can prolong the QT interval, leading to arrhythmias.

Interactions with Ketodan

Common Drug Interactions

  • CYP3A4 inhibitors: Other medications that inhibit this enzyme may increase the risk of side effects.
  • CYP3A4 inducers: Medications that induce this enzyme may reduce the effectiveness of ketoconazole.
  • Anticoagulants: Increased effects of anticoagulants (e.g., warfarin) can occur, necessitating closer monitoring.

Alternatives to Ketodan

  • Fluconazole: An antifungal that can be used for similar indications, especially systemic infections.
  • Itraconazole: Another oral antifungal option for various fungal infections.
  • Terbinafine: Often used for dermatophyte infections, particularly nail infections.