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Sildenafil Citrate
Sildenafil Citrate is the generic version of Viagra, the wellknown medication for treating erectile dysfunction (ED). It is also used to treat pulmonary arterial hypertension (PAH). It belongs to a drug class known as phosphodiesterase type 5 (PDE5) inhibitors, which work by blocking the PDE5 enzyme and reducing the breakdown of cGMP molecules which regulate blood flow in your body.
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Frequently Asked Questions
Can anyone take Sildenafil, or are there any restrictions?
Sildenafil is generally safe for most adults, but it may not be suitable for folks with certain health conditions or taking specific medications. Always consult your doctor or pharmacist before starting sildenafil.
Can I take Sildenafil as a daily medication, or do I only take it as needed?
Sildenafil is typically used on an asneeded basis. Your doctor may recommend daily use in certain cases, but always follow their instructions on dosage and frequency.
Can sildenafil be used to treat conditions other than erectile dysfunction?
Yes, sildenafil is also used to treat pulmonary arterial hypertension (PAH), an uncommon but serious condition affecting the blood vessels of the lungs. The medication helps to relax these blood vessels and improve symptoms, easing shortness of breath and increasing exercise capacity.
How long does it take for Sildenafil to start working?
Sildenafil usually begins to work within 30 to 60 minutes. It's best to take the medication around an hour before any planned sexual activity.
How often can I safely take sildenafil?
You can take sildenafil up to once a day, but it's important not to exceed your prescribed dose. Taking more than the recommended amount can lead to adverse effects or complications.
Is it okay to drink alcohol while taking sildenafil?
It's best to avoid or limit alcohol consumption when using sildenafil, as alcohol can potentially reduce the medication's effectiveness and cause side effects like dizziness or low blood pressure.
Comprehensive Drug Guide
How Does Sildenafil Citrate Work?
Sildenafil is a selective inhibitor of cGMPspecific phosphodiesterase type 5 (PDE5). PDE5 is responsible for the degradation of cGMP, which mediates the vasodilatory action of nitric oxide in the corpus cavernosum. By inhibiting PDE5, Sildenafil enhances the effect of NO and cGMP, leading to an increase in blood flow to the penis, facilitating erection during sexual arousal ?? ?? ??.
What is Sildenafil Citrate Used For?
Sildenafil is approved for the treatment of erectile dysfunction and pulmonary arterial hypertension.
Offlabel, Sildenafil may be prescribed for conditions such as Raynaud's phenomenon and female sexual arousal disorder.
Common Dosages
Sildenafil Citrate comes in tablet forms in strengths of 25mg, 50mg, 100mg and.
Typical Dosing
FDA Approved Indications
- Erectile Dysfunction: the recommended dosage of Viagra is 50 mg, taken as needed about 1 hour before sexual activity. You can take it 30 minutes to 4 hours before sexual activity and should not take more than one dose per day. Depending on how Viagra works, your doctor may suggest decreasing your dose to as low as 25 mg or as high as100 mg ?? ??.
- Pulmonary Arterial Hypertension (PAH): 20mg is taken three times each day, about 4 to 6 hours apart ?? ??.
Who Shouldn't Take Sildenafil Citrate?
- People with severe heart or liver problems
- Those who recently had a heart attack or stroke
- People with low blood pressure (hypotension) or uncontrolled high blood pressure (hypertension)
- Those with retinitis pigmentosa or those who have vision loss due to anterior ischemic optic neuropathy (NAION) should avoid sildenafil.
- If you are taking medications such as nitrates, certain antifungal medications and antibiotics, HIV protease inhibitors, or others you should consult with your doctor before taking sildenafil.
Advice From The Pharmacist
- Interactions with Nitrates: Do not take sildenafil if you're using nitrate medications (like nitroglycerin) for chest pain. The combination can cause a significant drop in blood pressure.
- Prolonged Erection: If you experience an erection lasting more than 4 hours, seek medical attention immediately.
- Vision Changes: Sildenafil can cause temporary vision changes, such as a blue tint or even sudden vision loss. If vision changes occur, stop the drug and contact your doctor.
- Heart Risks: If you have heart problems and experience symptoms like chest pain, dizziness, or nausea during sexual activity, discontinue the activity and seek medical help immediately.
Side Effects of Sildenafil Citrate
Common Side Effects
- Headaches
- Flushing
- Upset stomach
- Abnormal vision, such as changes in color vision and blurred vision
- Stuffy or runny nose
- Back pain
- Muscle pain
- Nausea
- Dizziness
- Rash
Uncommon/Severe Side Effects
- Sudden severe loss of vision
- Blurred vision
- Sudden decrease or loss of hearing
- Ringing in ears (tinnitus) or dizziness
- Erection that is painful or lasts longer than 4 hours (priapism)
- Heart attacklike symptoms, such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
- Irregular heartbeat
- Swelling in hands, ankles, or feet
- Shortness of breath
- Seizures
- Lightheadedness
Risks and Warnings of Sildenafil Citrate
- Interactions with Nitrates: Do not take sildenafil if you're using nitrate medications (like nitroglycerin) for chest pain. The combination can cause a significant drop in blood pressure.
- Prolonged Erection: If you experience an erection lasting more than 4 hours, seek medical attention immediately.
- Vision Changes: Sildenafil can cause temporary vision changes, such as a blue tint or even sudden vision loss. If vision changes occur, stop the drug and contact your doctor.
- Heart Risks: If you have heart problems and experience symptoms like chest pain, dizziness, or nausea during sexual activity, discontinue the activity and seek medical help immediately.
Interactions with Sildenafil Citrate
Common Drug Interactions
- Nitrates (e.g., Nitroglycerin, Isosorbide Mononitrate, Isosorbide Dinitrate): Taking these in combination with sildenafil may cause a serious drop in blood pressure.
- Alphablockers (e.g., Terazosin, Tamsulosin): Combined with sildenafil, these can lead to hypotension (low blood pressure).
- Antifungal medications (e.g., Ketoconazole, Itraconazole): These can increase the concentration of sildenafil in the blood, potentially enhancing its side effects.
- Certain antibiotics (e.g., Erythromycin, Clarithromycin): These may increase sildenafil blood levels, leading to increased side effects.
- HIV protease inhibitors (e.g., Ritonavir, Saquinavir): These can also increase blood concentrations of sildenafil, potentially enhancing its side effects.
- Guanylate Cyclase (GC) stimulators (e.g., Riociguat, Vericiguat): This combination could potentially lead to a significant drop in blood pressure.
- Certain Hepatitis C medication (e.g., Boceprevir, Telaprevir): These can increase the concentration of sildenafil in your blood, leading to potential side effects.
- Other PDE5 inhibitors (e.g., Tadalafil, Vardenafil): These medications have similar effects to sildenafil, and taking them together can increase the risk of side effects.
- Certain Blood pressure medicines (e.g., Amlodipine): This combination might cause an additional lowering of blood pressure.
Alternatives to Sildenafil Citrate
- Tadalafil (Cialis)
- Vardenafil (Levitra, Staxyn)
- Avanafil (Stendra)
- Alprostadil (Caverject, Edex, MUSE): This is a different type of medication that comes as an injection or a pellet.
