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Stendra
Stendra (generic name: avanafil) is a prescription medication used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which help increase blood flow to the penis during sexual stimulation, resulting in an erection. Stendra is known for its fast onset of action, often working within 15 to 30 minutes, and can be taken closer to the time of sexual activity compared to other ED medications. It is typically used on an as-needed basis and is well-tolerated with fewer side effects for most users.
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Frequently Asked Questions
How quickly does Stendra work?
Stendra typically begins working within 15 to 30 minutes after taking the medication, making it one of the fastest-acting ED treatments available.
Can I take Stendra with food?
Yes, Stendra can be taken with or without food. However, taking it with a high-fat meal may delay the onset of action.
How long does Stendra last?
The effects of Stendra can last for up to 6 hours, although it may vary from person to person.
Can I take Stendra every day?
Stendra is typically taken on an as-needed basis for erectile dysfunction. It is not intended for daily use, and you should not take more than one dose in a 24-hour period.
Is Stendra safe for long-term use?
Yes, Stendra is generally considered safe for long-term use when taken as prescribed. However, your doctor will monitor your condition and response to the medication during ongoing treatment.
Comprehensive Drug Guide
How Does Stendra Work?
Stendra works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which regulates blood flow in the penis. During sexual arousal, the body releases nitric oxide, which stimulates the production of cyclic guanosine monophosphate (cGMP). cGMP causes the muscles in the penile blood vessels to relax, allowing increased blood flow and resulting in an erection. By blocking PDE5, Stendra helps maintain higher levels of cGMP, promoting blood flow to the penis and improving erectile function.
Common Dosages
- 50 mg tablet
- 100 mg tablet
- 200 mg tablet
Typical Dosing
- The recommended starting dose of Stendra is 100 mg, taken approximately 15 to 30 minutes before sexual activity. The dose can be adjusted based on individual response, with the maximum recommended dose being 200 mg and the minimum dose being 50 mg.
- Stendra can be taken with or without food, but high-fat meals may delay its onset of action.
- Do not take more than one dose of Stendra within a 24-hour period.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction (ED)
Who Shouldn't Take Stendra?
- Concurrent use of nitrates (such as nitroglycerin) for chest pain or heart problems, as this combination can cause a dangerous drop in blood pressure.
- Severe heart or liver problems.
- Recent history of stroke or heart attack.
- Known hypersensitivity or allergic reaction to avanafil or any component of the formulation.
Advice From The Pharmacist
- Stendra should be taken about 15 to 30 minutes before sexual activity. It is faster-acting than other ED medications, making it a convenient option for those who prefer less planning.
- Avoid consuming large amounts of alcohol while taking Stendra, as this can increase the risk of side effects such as dizziness, fainting, or low blood pressure.
- Stendra does not protect against sexually transmitted infections (STIs) or function as a form of contraception. Use proper protection during sexual activity.
- Store Stendra at room temperature and keep it away from moisture and heat.
Side Effects of Stendra
Common Side Effects
- Headache
- Flushing (redness of the face or neck)
- Nasal congestion
- Back pain
- Dizziness
Uncommon/Severe Side Effects
- Priapism (an erection lasting more than 4 hours)
- Sudden vision loss
- Sudden hearing loss
- Severe hypotension (low blood pressure), especially when combined with nitrates or certain blood pressure medications.
Risks and Warnings of Stendra
- Nitrate Interaction: Stendra must never be used in combination with nitrates (e.g., nitroglycerin) or nitric oxide donors (e.g., amyl nitrite, "poppers") due to the risk of life-threatening drops in blood pressure.
- Priapism: If an erection lasts longer than 4 hours (priapism), seek immediate medical attention. Untreated priapism can cause permanent damage to the penis.
- Cardiovascular Risk: Sexual activity itself can place additional strain on the heart. Men with heart problems should consult their doctor before using Stendra.
Interactions with Stendra
Common Drug Interactions
- Nitrates: Stendra should never be used with nitrates (e.g., nitroglycerin) or nitric oxide donors, as the combination can cause a severe drop in blood pressure.
- Alpha-blockers: Medications used to treat high blood pressure or prostate conditions, such as tamsulosin, may cause low blood pressure when taken with Stendra.
- Alcohol: Excessive alcohol use can increase the risk of side effects such as dizziness and low blood pressure.
- Other PDE5 inhibitors: Do not take Stendra with other PDE5 inhibitors (e.g., sildenafil, tadalafil, vardenafil) as this increases the risk of side effects.
Alternatives to Stendra
- Viagra (sildenafil): Another PDE5 inhibitor that is commonly used to treat erectile dysfunction. It is usually taken 30 to 60 minutes before sexual activity.
- Cialis (tadalafil): A PDE5 inhibitor known for its long-lasting effects, allowing for up to 36 hours of effectiveness.
- Levitra (vardenafil): Another PDE5 inhibitor used to treat erectile dysfunction, taken 30 to 60 minutes before sexual activity.
- Alprostadil: An alternative treatment for ED that can be injected or inserted into the urethra for patients who do not respond to oral PDE5 inhibitors.
