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Cialis
Cialis (tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor primarily used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and in some cases, pulmonary arterial hypertension (PAH). Cialis helps increase blood flow to the penis, enabling men with ED to achieve and maintain an erection. It is also used to relieve the symptoms of BPH, such as difficulty urinating or frequent urination. Cialis is well-known for its long duration of action, often referred to as the "weekend pill" because it can work up to 36 hours after a dose.
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Frequently Asked Questions
How long does Cialis last?
Cialis can last up to 36 hours after taking a dose, allowing for more flexibility compared to other ED medications.
Can I take Cialis every day?
Yes, Cialis can be taken daily at a lower dose (2.5 mg or 5 mg) for those who prefer continuous treatment, particularly for men who engage in sexual activity more than twice a week.
How quickly does Cialis work?
Cialis typically starts working within 30 minutes to 2 hours after ingestion. Sexual stimulation is required for it to work effectively.
Can Cialis be used to treat conditions other than erectile dysfunction?
Yes, Cialis is also prescribed to treat benign prostatic hyperplasia (BPH) and, under the name Adcirca, for pulmonary arterial hypertension (PAH).
What should I do if I experience an erection lasting more than 4 hours?
Seek immediate medical attention. This condition, known as priapism, can cause permanent damage to the penis if not treated promptly.
Comprehensive Drug Guide
How Does Cialis Work?
Cialis works by inhibiting PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a molecule responsible for relaxing the smooth muscles and increasing blood flow to certain areas of the body, particularly the penis. In the presence of sexual stimulation, this increased blood flow helps facilitate an erection. Additionally, Cialis relaxes the smooth muscles in the prostate and bladder, easing symptoms of benign prostatic hyperplasia (BPH).
Common Dosages
- 2.5 mg tablets (for daily use)
- 5 mg tablets (for daily use or as needed)
- 10 mg tablets (for as-needed use)
- 20 mg tablets (for as-needed use)
Typical Dosing
- For erectile dysfunction (ED): The typical starting dose is 10 mg taken 30 minutes before sexual activity. Depending on efficacy and tolerability, the dose may be adjusted to 20 mg or decreased to 5 mg. Cialis can also be taken as a once-daily medication at a dose of 2.5 mg to 5 mg for those who prefer continuous treatment.
- For benign prostatic hyperplasia (BPH): The recommended dose is 5 mg once daily.
- For ED and BPH combined: 5 mg once daily is the usual dosage.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction (ED)
- Benign prostatic hyperplasia (BPH)
- ED and BPH combined
- Pulmonary arterial hypertension (PAH) (marketed under a different name, Adcirca)
Who Shouldn't Take Cialis?
- Severe heart conditions (e.g., recent heart attack or unstable angina)
- Severe liver or kidney disease without dose adjustment
- Patients taking nitrates (e.g., nitroglycerin), as the combination can cause a dangerous drop in blood pressure
- Known hypersensitivity to tadalafil or any component of the formulation
Advice From The Pharmacist
- Take Cialis exactly as prescribed, with or without food.
- Avoid excessive alcohol consumption, as it can reduce the effectiveness of Cialis and increase the risk of side effects such as dizziness.
- Do not take Cialis if you are using nitrates or alpha-blockers without consulting your doctor, as these medications can interact dangerously with tadalafil.
- Store Cialis at room temperature, away from moisture and heat.
Side Effects of Cialis
Common Side Effects
- Headache
- Indigestion
- Back pain
- Muscle aches
- Flushing
- Nasal congestion
Uncommon/Severe Side Effects
- Priapism (an erection lasting more than 4 hours, which requires immediate medical attention)
- Vision changes or loss of vision (rare)
- Sudden hearing loss (rare)
- Allergic reactions such as rash, swelling, or difficulty breathing
Risks and Warnings of Cialis
- Hypotension: Cialis can cause a significant drop in blood pressure, particularly when used in combination with nitrates or alpha-blockers.
- Cardiovascular events: Men with heart conditions should consult their doctor before using Cialis, especially if they are not healthy enough for sexual activity.
- Priapism: Prolonged erections lasting more than 4 hours require immediate medical attention to prevent permanent damage to the penis.
Interactions with Cialis
Common Drug Interactions
- Nitrates: The combination of Cialis with nitrates can cause a dangerous drop in blood pressure.
- Alpha-blockers: When used together, these can increase the risk of low blood pressure.
- Antifungal medications (e.g., ketoconazole) and HIV protease inhibitors (e.g.,
Alternatives to Cialis
- Viagra (sildenafil): Another PDE5 inhibitor used for erectile dysfunction with a shorter duration of action (4-6 hours).
- Levitra (vardenafil): A PDE5 inhibitor with a similar onset of action to Viagra.
- Stendra (avanafil): A newer PDE5 inhibitor with a faster onset of action and fewer side effects.
- Alprostadil: Available as an injection or urethral suppository for erectile dysfunction.
