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Muse
Muse is the brand name for alprostadil, a medication used to treat erectile dysfunction (ED) in men. It is administered as a urethral suppository, which delivers the medication directly to the penis to improve blood flow and help achieve an erection. Alprostadil belongs to the prostaglandin E1 class of drugs, which work by relaxing blood vessels and increasing blood flow to the penis. Unlike oral ED medications like sildenafil (Viagra), Muse is applied locally and acts more quickly for some patients.
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Frequently Asked Questions
How quickly does Muse work?
Muse typically works within 5 to 10 minutes after administration, and the erection can last for 30 to 60 minutes.
Can I use Muse more than once a day?
It is recommended not to use Muse more than twice in a 24-hour period. Overuse may increase the risk of side effects such as priapism.
Does Muse work for all types of erectile dysfunction?
Muse may be effective for men with mild to moderate ED or for those who do not respond well to oral medications. It may not be effective for men with severe vascular or neurological conditions affecting erections.
Can my partner be affected by Muse during intercourse?
In rare cases, female partners may experience vaginal irritation or discomfort after intercourse. If this occurs, discuss it with your doctor.
Is Muse painful to use?
Some men may experience mild discomfort or a burning sensation when inserting the suppository into the urethra. If the pain is severe or persists, speak to your healthcare provider.
Comprehensive Drug Guide
How Does Muse Work?
Muse works by delivering alprostadil directly into the urethra, where it is absorbed into the surrounding tissues of the penis. Alprostadil acts as a vasodilator, relaxing the smooth muscles of the blood vessels and allowing increased blood flow into the penile tissues. This increased blood flow results in an erection. The action is local, meaning it only affects the area where it is applied.
Common Dosages
- 125 mcg, 250 mcg, 500 mcg, and 1000 mcg urethral suppositories
- The dosage is individualized, typically starting at 500 mcg and adjusted based on the patient’s response.
Typical Dosing
- The usual recommended starting dose is 500 mcg, administered once daily as needed prior to sexual activity.
- Muse should be inserted into the urethra using the applicator 5 to 10 minutes before intercourse.
- Do not use more than two doses in 24 hours.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction (ED) in men, particularly in those who do not respond well to oral medications for ED or prefer a non-oral treatment option.
Who Shouldn't Take Muse?
- Known hypersensitivity or allergic reaction to alprostadil or any components of Muse
- Men with conditions that predispose them to priapism (prolonged erection), such as sickle cell anemia, leukemia, or multiple myeloma
- Men with anatomical abnormalities of the penis, such as severe curvature, urethral stricture, or Peyronie's disease
- Individuals prone to bleeding disorders
Advice From The Pharmacist
- Muse should be used as prescribed by your healthcare provider. Insert the urethral suppository using the applicator, and avoid urinating for at least 30 minutes after administration to ensure proper absorption.
- Erections usually occur within 5 to 10 minutes and can last for 30 to 60 minutes.
- Always use Muse as directed and avoid using more than two doses in a 24-hour period.
- Common side effects may include mild pain or burning in the urethra during application. If these symptoms persist or worsen, consult your healthcare provider.
Side Effects of Muse
Common Side Effects
- Mild pain or burning in the urethra or penis
- Lightheadedness or dizziness
- Penile redness or swelling
- Temporary aching in the testes
Uncommon/Severe Side Effects
- Priapism (prolonged erection lasting more than 4 hours)
- Significant penile pain or discomfort
- Severe dizziness or fainting
Risks and Warnings of Muse
- Priapism: In rare cases, Muse can cause priapism, a prolonged and painful erection lasting more than 4 hours. This is a medical emergency and requires immediate treatment to prevent permanent damage to the penis.
- Urethral Bleeding: Some men may experience minor urethral bleeding after inserting the suppository. If the bleeding is significant or does not stop, contact your doctor.
- Use in Partners: In rare cases, female partners may experience vaginal irritation or discomfort after sexual intercourse with a man using Muse. It is important to discuss any concerns with your healthcare provider.
- Cardiovascular Risk: Since Muse increases blood flow, it may not be suitable for men with certain heart conditions. Always inform your doctor about any heart problems or medications you are taking.
Interactions with Muse
Common Drug Interactions
- Antihypertensives: If you are taking blood pressure medications, using Muse may cause a drop in blood pressure, resulting in dizziness or fainting.
- Anticoagulants: If you are on blood thinners, there may be an increased risk of bleeding when using Muse.
- Other ED medications: Do not use Muse in combination with other erectile dysfunction treatments, such as Viagra (sildenafil) or Cialis (tadalafil), without consulting your doctor.
Alternatives to Muse
- Viagra (sildenafil): An oral medication used for erectile dysfunction, it works by increasing blood flow to the penis.
- Cialis (tadalafil): A longer-lasting oral medication for ED that can be taken as needed or daily.
- Trimix injections: A combination of medications injected into the penis to induce an erection.
- Caverject (alprostadil injection): An injectable form of alprostadil used for ED.
- Vacuum erection devices (VEDs): A non-pharmaceutical option for inducing erections by creating a vacuum around the penis to draw blood into it.
