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Caverject

Caverject is an injectable medication containing alprostadil, a vasodilator used to treat erectile dysfunction (ED). Alprostadil works by relaxing blood vessels and increasing blood flow to the penis, helping men achieve and maintain an erection. It is typically used when oral medications for ED, such as sildenafil (Viagra), are ineffective or not suitable. Caverject is injected directly into the penis to produce an erection.

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Frequently Asked Questions

How long does it take for Caverject to work?
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Caverject typically begins to work within 5 to 20 minutes after injection. The resulting erection usually lasts between 30 and 60 minutes.

Is it safe to use Caverject more than once a day?
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No, Caverject should not be used more than once in a 24-hour period, and it should not be used more than 3 times per week to reduce the risk of complications like priapism or penile damage.

What should I do if I experience an erection lasting more than 4 hours?
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If you experience an erection lasting more than 4 hours (priapism), seek immediate medical attention to prevent permanent damage to the tissues in your penis.

Can I use Caverject if oral ED medications don’t work for me?
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Yes, Caverject is often prescribed to men who do not respond to oral ED medications such as sildenafil (Viagra) or tadalafil (Cialis). However, it is important to discuss with your doctor whether Caverject is appropriate for you.

Does Caverject increase sexual desire?
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No, Caverject does not affect sexual desire or libido. It only helps achieve and maintain an erection by increasing blood flow to the penis.

Can Caverject be used in combination with other ED treatments?
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Caverject should not be used with other ED treatments like oral medications (e.g., sildenafil or tadalafil) without the supervision of a healthcare provider, as combining treatments may increase the risk of side effects such as priapism.

Comprehensive Drug Guide

How Does Caverject Work?

Caverject works by relaxing the smooth muscles of the blood vessels in the penis, allowing more blood to flow into the area and creating an erection. Alprostadil binds to specific receptors in the penis, causing an increase in cyclic adenosine monophosphate (cAMP), which leads to smooth muscle relaxation and vasodilation. This effect promotes erection within minutes of injection.

What is Caverject Used For?

Erectile Dysfunction (ED): Used to treat men who have difficulty achieving or maintaining an erection suitable for sexual activity.

Diagnosis of Erectile Dysfunction: It is sometimes used in diagnostic tests for evaluating erectile function.

Common Dosages

Caverject is available by prescription only and is not classified as a controlled substance. It is supplied as a powder that must be reconstituted with sterile water before injection. It is available in the following strengths:

  • 5 mcg, 10 mcg, 20 mcg, and 40 mcg for injection.

Administration: Caverject is injected directly into the side of the penis (corpus cavernosum) using a very fine needle. Patients are typically trained by a healthcare provider on how to administer the injection correctly.

Frequency: Caverject should not be used more than 3 times per week, and there must be at least 24 hours between doses.

Duration of Use: Caverject is used on an as-needed basis, with the erection occurring within 5 to 20 minutes after injection and lasting about 30 to 60 minutes.

Typical Dosing

FDA Approved Indications

Caverject dosages vary depending on the patient’s needs and response to the medication. The initial dose is usually 2.5 mcg to 10 mcg, and it may be adjusted by the healthcare provider based on response. Typical dosages range from:

  • 5 mcg to 20 mcg administered as needed before sexual activity.
  • The maximum recommended dose is 60 mcg per injection.

Who Shouldn't Take Caverject?

Caverject is contraindicated in patients with:

  • Hypersensitivity to alprostadil or any component of the formulation.
  • Conditions that predispose them to priapism (prolonged erection), such as sickle cell anemia, multiple myeloma, or leukemia.
  • Anatomical deformities of the penis (e.g., Peyronie’s disease or fibrosis).
  • Penile implants.

Advice From The Pharmacist

Patients using Caverject should be advised to:

  • Follow the proper injection technique as instructed by their healthcare provider to avoid complications such as bruising or pain.
  • Rotate the injection site on the penis with each dose to avoid tissue damage.
  • Contact their healthcare provider immediately if they experience an erection lasting longer than 4 hours (priapism), as this is a medical emergency.
  • Avoid using Caverject more than 3 times per week, with at least 24 hours between injections.
  • Store the reconstituted solution at the proper temperature and discard any unused portion after the recommended time.


Side Effects of Caverject

Common Side Effects

  • Pain at the injection site
  • Mild bleeding or bruising at the injection site
  • Penile pain during or after erection
  • Prolonged erections (priapism)


Uncommon/Severe Side Effects

  • Priapism (Prolonged Erection): An erection lasting more than 4 hours requires immediate medical attention to prevent permanent damage to the penis.
  • Penile Fibrosis: Repeated injections can lead to scarring or fibrous tissue formation in the penis.
  • Injection Site Reactions: Severe pain, swelling, or infection at the injection site.

Risks and Warnings of Caverject

  • Priapism: Prolonged erections are a known risk with Caverject. Patients should seek immediate medical help if they experience an erection lasting longer than 4 hours, as priapism can cause permanent damage to the penis.
  • Penile Fibrosis: Repeated injections into the same area of the penis can lead to scarring or the formation of fibrous tissue. Rotating injection sites and proper administration techniques can help reduce this risk.
  • Infection: Improper injection technique can increase the risk of infection at the injection site.
  • Cardiovascular Events: Although rare, patients with underlying cardiovascular conditions should use Caverject with caution, as sexual activity may strain the heart.

Interactions with Caverject

Common Drug Interactions

Caverject may interact with other medications that affect blood flow or increase the risk of bleeding, including:

  • Blood thinners (anticoagulants): Such as warfarin or heparin, which can increase the risk of bleeding or bruising at the injection site.
  • Other ED medications: Such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), which should not be used in combination with Caverject without medical supervision.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.



Alternatives to Caverject

Alternative treatments for erectile dysfunction include:

  • Oral ED Medications: Such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra), which are typically tried before injectable treatments.
  • Vacuum Erection Devices (VEDs): A non-invasive option that uses a vacuum pump to help achieve an erection.
  • Penile Implants: A surgical option for men who do not respond to other ED treatments.
  • Intraurethral Alprostadil (MUSE): A small suppository inserted into the urethra that releases alprostadil.