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Nabumetone
Nabumetone is a nonsteroidal antiinflammatory drug (NSAID) that is used for pain relief, inflammation reduction, and fever reduction. It's primarily used to treat arthritis (osteoarthritis and rheumatoid arthritis). Some common side effects include indigestion, diarrhea, and headache, but your doctor will always weigh the risks versus the benefits before prescribing it.
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Frequently Asked Questions
Can I take Nabumetone if I have heart disease?
Your doctor will need to assess the risks and benefits, as nabumetone may increase the risk of heart attack or stroke.
Can I take this medication while pregnant?
No, it's not recommended, especially in the last trimester. Always consult your doctor.
I missed a dose of Nabumetone, what should I do?
No worries, if it's close to the time you're supposed to take the next dose, then skip the missed one. Otherwise, take the dose as soon as you remember. However, don't double up, stick to your regular schedule.
When will my symptoms improve with Nabumetone?
This varies from person to person. Some may feel relief within days, while for others, it may take a few weeks. Always consult with your doctor.
Comprehensive Drug Guide
How Does Nabumetone Work?
Nabumetone is a prodrug that, once metabolized in the liver, inhibits the enzyme cyclooxygenase which reduces the formation of prostaglandins?substances responsible for pain, inflammation, and fever.
What is Nabumetone Used For?
FDA indications: Nabumetone is specifically used to manage symptoms of osteoarthritis and rheumatoid arthritis, including inflammation, pain, and joint swelling.
Offlabel uses: While there are no offlabel uses for nabumetone, a consultation with your healthcare provider might reveal other potential uses depending on your particular situation.
Common Dosages
Tablets: 500mg, 750mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Osteoarthritis and rheumatoid arthritis: 1000mg per day. This may be increased based on the patient's response to therapy up to a maximum of 2000mg per day.
Who Shouldn't Take Nabumetone?
- Anybody known to be allergic to nabumetone or other NSAIDs.
- Individuals with a history of peptic ulcers or gastrointestinal bleeding.
- Individuals who have recently undergone heart surgery.
- People who've had an asthma attack, hives, or other allergic reactions after taking an NSAID.
- People with known chronic heart conditions.
- Pregnant women, particularly in their third trimester.
Advice From The Pharmacist
- Take nabumetone with a full glass of water and preferably a meal to avoid an upset stomach.
- If you've switched from regular nabumetone tablets to extendedrelease tablets, keep in mind that you might not notice the benefits right away.
- Don?t lie down for about 10 minutes after taking the medication.
- Contact your healthcare provider if you notice any unexplained weight gain or swelling.
- If you have a persistent stomach upset, inform your doctor.
- Monitor your blood pressure regularly, and share the result with your doctor.
- It?s important to notify your healthcare practitioner if you have any symptoms such as chest pain, shortness of breath, weakness, or slurring of speech.
Side Effects of Nabumetone
Common Side Effects
- indigestion, nausea, diarrhea, and headache.
Uncommon/Severe Side Effects
- stomach ulcers or bleeding, heart attack, stroke, high blood pressure, heart failure, kidney problems, or liver disease.
Risks and Warnings of Nabumetone
- People with heart disease or risks for heart disease may be at greater risk as it may increase the chance of a heart attack or stroke.
- Longterm use may lead to stomach or intestine problems, including ulcers and bleeding.
- Nabumetone may cause kidney issues. You must inform your healthcare provider if you have previously had kidney problems or are at risk.
- Uncontrolled high blood pressure patients should exercise caution when taking nabumetone as it may worsen the condition.
- Not suitable for pregnant women, particularly in the third trimester.
Interactions with Nabumetone
Common Drug Interactions
- Anticoagulants (e.g., warfarin)
- ACE inhibitors (e.g., captopril, lisinopril)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Biologics (e.g., etanercept, infliximab)
- Cyclosporine
- Lithium
Alternatives to Nabumetone
- Ibuprofen (Advil, Motrin)
- Naproxen (Aleve)
- Celecoxib (Celebrex)
- Etodolac (Lodine)
- Meloxicam (Mobic)
