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Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for various conditions, including arthritis, muscle pain, tendonitis, dental pain, and menstrual cramps.
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Frequently Asked Questions
How quickly does naproxen work?
Naproxen typically starts to relieve pain within 30 minutes to 1 hour, with maximum effects often seen within a few hours.
Can I take naproxen with food?
Yes, taking naproxen with food or milk can help reduce gastrointestinal irritation.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using naproxen?
There are no specific dietary restrictions while using naproxen.
Is naproxen safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using naproxen, particularly in the third trimester, as it may pose risks to the fetus.
Comprehensive Drug Guide
How Does Naproxen Work?
Naproxen works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which play key roles in the production of prostaglandins—compounds involved in the inflammatory response, pain, and fever. By reducing prostaglandin production, naproxen alleviates pain and inflammation.
Common Dosages
- Tablets: 250 mg, 500 mg, and 750 mg.
- Liquid Suspension: 125 mg/5 mL.
Typical Dosing
- For acute pain: The usual initial dose is 500 mg, followed by 250 mg every 6 to 8 hours as needed, not to exceed 1,250 mg in the first day.
- For arthritis: The recommended dose is usually 250 mg to 500 mg twice daily, based on individual response.
Typical Dosing
FDA Approved Indications
- Acute Pain: including headache, dental pain, and menstrual cramps.
- Chronic Pain: associated with conditions such as arthritis and ankylosing spondylitis.
- Fever Reduction: to help lower fever.
Who Shouldn't Take Naproxen?
- Known hypersensitivity to naproxen or other NSAIDs.
- Active gastrointestinal bleeding or peptic ulcer disease.
- Severe kidney or liver disease.
Advice From The Pharmacist
- Take naproxen with food or milk to help minimize gastrointestinal irritation.
- Avoid taking other NSAIDs concurrently unless directed by a healthcare provider.
- Monitor for signs of gastrointestinal bleeding (e.g., black or bloody stools) and report them immediately.
Side Effects of Naproxen
Common Side Effects
- Upset stomach or indigestion
- Dizziness
- Headache
- Drowsiness
- Rash
Uncommon/Severe Side Effects
- Gastrointestinal bleeding
- Kidney problems (symptoms include decreased urine output or swelling)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Naproxen
- Gastrointestinal Risk: NSAIDs can increase the risk of serious gastrointestinal events; use the lowest effective dose for the shortest duration necessary.
- Cardiovascular Risk: Long-term use may increase the risk of heart attack or stroke; monitor patients with existing cardiovascular conditions.
- Kidney Effects: Use with caution in patients with pre-existing kidney disease or those on diuretics.
Interactions with Naproxen
Common Drug Interactions
- Anticoagulants: Increased risk of bleeding when taken with blood thinners (e.g., warfarin).
- Other NSAIDs: Avoid combining with other NSAIDs to reduce the risk of gastrointestinal side effects.
Alternatives to Naproxen
- Other NSAIDs: Such as ibuprofen or ketoprofen for similar indications.
- Acetaminophen: As an alternative for pain relief if NSAIDs are contraindicated.
