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cycloSPORINE
Cyclosporine is a medication that belongs to the class of drugs known as immunosuppressants. It helps to control your body's immune system to prevent it from rejecting transplanted organs or to treat certain autoimmune diseases. Common side effects can include headaches, abdominal discomfort, and high blood pressure, although your healthcare provider will closely monitor you to ensure the benefits outweigh these potential concerns.
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Frequently Asked Questions
Can Cyclosporine cause weight gain?
Cyclosporine doesn't typically cause weight gain, but it can occur due to associated water retention with longterm use.
Can Cyclosporine cause weight gain?
Cyclosporine doesn't typically cause weight gain, but it can occur due to associated water retention with longterm use.
Can I just stop taking Cyclosporine?
Abruptly stopping the use of cyclosporine can lead to organ rejection or severe flareups of your autoimmune condition. It's important to taper the dose under your doctor's supervision.
Can I just stop taking Cyclosporine?
Abruptly stopping the use of cyclosporine can lead to organ rejection or severe flareups of your autoimmune condition. It's important to taper the dose under your doctor's supervision.
If I drink alcohol while taking Cyclosporine what could happen?
Alcohol may have negative effects on the liver, and since cyclosporine is processed in the liver, this could potentially worsen any side effects; it's best to limit your alcohol intake while taking Cyclosporine.
If I drink alcohol while taking Cyclosporine what could happen?
Alcohol may have negative effects on the liver, and since cyclosporine is processed in the liver, this could potentially worsen any side effects; it's best to limit your alcohol intake while taking Cyclosporine.
Is Cyclosporine a steroid?
Cyclosporine is not a steroid. It is an immunosuppressant, a drug that suppresses the immune response.
Is Cyclosporine a steroid?
Cyclosporine is not a steroid. It is an immunosuppressant, a drug that suppresses the immune response.
What if I forget to take a dose?
If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed dose. Don't take double doses to make up for a missed dose.
What if I forget to take a dose?
If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed dose. Don't take double doses to make up for a missed dose.
What should I do if I experience side effects?
If you experience any unwelcome side effects from Cyclosporine, report them to your healthcare provider immediately. Depending on the type and severity of the side effect, your doctor may adjust your dosage or suggest an alternative medication.
What should I do if I experience side effects?
If you experience any unwelcome side effects from Cyclosporine, report them to your healthcare provider immediately. Depending on the type and severity of the side effect, your doctor may adjust your dosage or suggest an alternative medication.
Comprehensive Drug Guide
How Does cycloSPORINE Work?
Cyclosporine is a powerful immunosuppressive agent that inhibits Tlymphocytes, a type of white blood cell that plays a major role in the body's immune response. It reduces the activity of the immune system, minimizing the risk of organ transplant rejection and alleviating the symptoms of autoimmune diseases.
What is cycloSPORINE Used For?
FDA indications: Cyclosporine is employed to prevent organ rejection in transplant patients and treat several autoimmune disorders such as psoriasis and rheumatoid arthritis.
Offlabel uses: It's also used offlabel to treat severe Atopic Dermatitis and Ulcerative Colitis.
Common Dosages
Capsules: 25mg, 100 mg
Oral solution: 100 mg/mL
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Organ Transplantation: The dosage varies depending on the type of organ transplanted, the patient's weight, and other medications being used in the management of the patient.
- Psoriasis and Rheumatoid Arthritis: The dose is individualized based on the patient's medical condition and response to treatment, typically between 1.25 to 5 mg per kilogram of body weight per day.
Off-Label Uses
- For offlabel uses:
- Severe Atopic Dermatitis & Ulcerative Colitis: The dose is usually 5mg per kilogram of body weight per day, but it might be adjusted by the healthcare provider.
Who Shouldn't Take cycloSPORINE?
- People who are allergic to cyclosporine or any of its components.
- Patients who have a history of liver or kidney disease.
- Patients with uncontrolled high blood pressure.
- Those with certain types of cancer.
- Women who are pregnant, planning to become pregnant, or breastfeeding should use cyclosporine cautiously as its effects on the baby are unknown.
- People with a history of gout or high levels of uric acid in the blood, those who have been recently vaccinated or are due for a vaccination.
- Patients with abnormal levels of magnesium in their blood.
Advice From The Pharmacist
- Limit your time in the sun as cyclosporine can make your skin more sensitive to sunlight leading to sunburn.
- Stay hydrated, cyclosporine can sometimes cause kidney problems, and keeping hydrated can protect your kidneys.
- Take your dose at the same time every day to maintain consistent levels in your blood.
- Avoid eating grapefruit or drinking grapefruit juice when taking cyclosporine. Grapefruit can increase the amount of this medicine in your bloodstream.
- Monitor your blood pressure regularly and report any substantive changes to your doctor.
- Get regular blood tests to monitor your kidney function, liver function, blood pressure, and blood levels of cyclosporine.
- Make sure you maintain good oral hygiene. Cyclosporine can cause gum overgrowth (gingival hyperplasia).
Side Effects of cycloSPORINE
Common Side Effects
- Increased body hair growth, gum overgrowth, high blood pressure, and kidney problems
Uncommon/Severe Side Effects
- Uncommon side effects:
- Nausea, vomiting, diarrhea, and tremors.
- Rare side effects:
- Nerverelated side effects like trembling hands, changes in speech or vision, muscular cramping or spasms, and tingling or numbness.
- Severe side effects:
- These include signs of organ rejection like fever, change in the amount of urine, and pain around the area of transplant. If these symptoms are noticed, medical attention should be immediately sought.
Risks and Warnings of cycloSPORINE
- Patients with a history of renal dysfunction should be careful while taking cyclosporine, as it may exacerbate their condition.
- Cyclosporine may raise blood pressure. Hence try to maintain a lowsodium diet and monitor your blood pressure regularly.
- Longterm use of cyclosporine can increase the risk of developing serious infections, lymphoma, and other types of cancer.
- Cyclosporine can affect your body?s ability to manage blood sugar levels, increasing the risk of developing diabetes.
- Be cautious if you are planning to receive a vaccination as vaccination effectiveness can be reduced during Cyclosporine treatment.
Interactions with cycloSPORINE
Common Drug Interactions
- Certain antibiotics and antifungals: like erythromycin, itraconazole
- Certain seizures or epilepsy medications: like carbamazepine, phenobarbital
- Certain heart or blood pressure medications: like diltiazem, verapamil, losartan
Alternatives to cycloSPORINE
- Tacrolimus
- Sirolimus
- Mycophenolate mofetil
- Azathioprine
- Methotrexate
