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Lodine
Lodine is a brand name for etodolac, a nonsteroidal anti-inflammatory drug (NSAID) used primarily to relieve pain and inflammation associated with conditions such as arthritis (including osteoarthritis and rheumatoid arthritis), as well as for short-term relief of pain from other sources, such as menstrual cramps and post-surgical pain.
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Frequently Asked Questions
How quickly does Lodine work?
Patients may begin to feel relief within 30 minutes to 1 hour after taking the medication
Can I take Lodine with food?
Yes, it is recommended to take Lodine with food or milk to help reduce gastrointestinal irritation.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Lodine?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable, particularly if you are monitoring blood pressure or gastrointestinal health.
Is Lodine safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Lodine.
Comprehensive Drug Guide
How Does Lodine Work?
Etodolac works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are responsible for converting arachidonic acid into prostaglandins. By reducing the production of these inflammatory mediators, Lodine helps to decrease pain, swelling, and fever.
Common Dosages
- Tablets: 400 mg, 500 mg, and 600 mg.
Typical Dosing
- The usual recommended dose for adults is 300 mg to 500 mg taken two to three times daily, depending on the severity of the pain and the specific condition being treated. The maximum daily dose should not exceed 1000 mg.
Typical Dosing
FDA Approved Indications
- Relief of Pain: including acute pain and chronic pain associated with arthritis.
- Anti-inflammatory Treatment: for conditions characterized by inflammation.
Who Shouldn't Take Lodine?
- Known hypersensitivity to etodolac or any component of the formulation.
- History of gastrointestinal bleeding or ulcers.
- Severe renal or hepatic impairment.
Advice From The Pharmacist
- Take Lodine with food or milk to minimize gastrointestinal irritation.
- Monitor for any signs of gastrointestinal bleeding, such as black or tarry stools.
- Use the lowest effective dose for the shortest duration necessary to manage symptoms.
Side Effects of Lodine
Common Side Effects
- Nausea
- Diarrhea
- Indigestion
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding
- Kidney problems (reduced urine output, swelling)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Lodine
- Cardiovascular Risk: NSAIDs may increase the risk of heart attack and stroke; use with caution in patients with cardiovascular disease.
- Gastrointestinal Risk: NSAIDs can lead to serious gastrointestinal issues, including bleeding and perforation, particularly in older adults.
- Kidney Function: Monitor renal function in patients with pre-existing kidney disease or those on long-term therapy.
Interactions with Lodine
Common Drug Interactions
- Gastrointestinal bleeding
- Kidney probleaOther NSAIDs: Use caution when combining with other NSAIDs or aspirin to avoid increased risk of gastrointestinal side effects.
- Anticoagulants: NSAIDs can increase the risk of bleeding when taken with blood thinners.
- Diuretics: Etodolac may reduce the effectiveness of certain diuretics.
- ms (reduced urine output, swelling)
- Severe allergic reactions (rash, itching, swelling)
Alternatives to Lodine
- Other NSAIDs: Such as ibuprofen or naproxen for pain and inflammation management.
- Acetaminophen: For pain relief without the anti-inflammatory effects.
- Corticosteroids: For more severe inflammatory conditions under a healthcare provider's guidance.
