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Mobic
Mobic (generic name: meloxicam) is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It helps reduce inflammation, pain, and swelling in the joints by inhibiting the production of certain natural substances in the body that cause inflammation. Mobic is commonly prescribed for long-term management of arthritis-related pain and inflammation.
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Frequently Asked Questions
How long does it take for Mobic to start working?
Mobic typically begins to relieve pain and inflammation within a few hours of the first dose, but it may take up to two weeks for the full therapeutic effects to be felt.
Can I take Mobic with food?
Yes, Mobic can be taken with or without food, but taking it with food or milk may help prevent stomach upset.
Is Mobic safe for long-term use?
Long-term use of Mobic can increase the risk of serious side effects, such as gastrointestinal bleeding, heart attack, stroke, and kidney problems. It should be used at the lowest effective dose for the shortest duration necessary.
Can I drink alcohol while taking Mobic?
It is recommended to limit or avoid alcohol while taking Mobic, as alcohol can increase the risk of stomach bleeding and other gastrointestinal side effects.
Can I take Mobic if I’m pregnant?
Mobic should not be taken during the third trimester of pregnancy, as it can harm the fetus. Consult your doctor if you are pregnant or planning to become pregnant while using this medication.
Comprehensive Drug Guide
How Does Mobic Work?
Mobic works by inhibiting the enzyme cyclooxygenase (COX), specifically COX-2, which is involved in the production of prostaglandins, substances in the body that cause inflammation, pain, and swelling. By reducing prostaglandin production, Mobic helps alleviate the symptoms of arthritis and other inflammatory conditions.
Common Dosages
- 7.5 mg and 15 mg tablets
- Oral suspension: 7.5 mg/5 mL
Typical Dosing
- For osteoarthritis and rheumatoid arthritis in adults: The typical starting dose is 7.5 mg once daily, which may be increased to 15 mg once daily depending on the patient's response and severity of symptoms. The maximum recommended daily dose is 15 mg.
- For juvenile rheumatoid arthritis (children 2 years and older): The typical dose is 0.125 mg/kg once daily, up to a maximum of 7.5 mg per day.
Typical Dosing
FDA Approved Indications
- Osteoarthritis: For the relief of the signs and symptoms of osteoarthritis.
- Rheumatoid arthritis: For the treatment of pain and inflammation associated with rheumatoid arthritis.
- Juvenile rheumatoid arthritis: For children aged 2 years and older to relieve the symptoms of juvenile rheumatoid arthritis.
Who Shouldn't Take Mobic?
- Known hypersensitivity to meloxicam or other NSAIDs.
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Active gastrointestinal bleeding or ulcers.
- Severe kidney or liver disease.
- Coronary artery bypass graft (CABG) surgery, as it increases the risk of cardiovascular complications.
Advice From The Pharmacist
- Take Mobic once daily, with or without food, though taking it with food or milk may help prevent stomach upset.
- Avoid taking other NSAIDs (like ibuprofen or aspirin) while using Mobic unless directed by your doctor.
- Alcohol can increase the risk of stomach bleeding, so it’s best to limit or avoid alcohol while taking Mobic.
- If you have a history of stomach ulcers or gastrointestinal bleeding, inform your healthcare provider, as Mobic can increase the risk of these complications.
- Store Mobic at room temperature, away from moisture and heat.
Side Effects of Mobic
Common Side Effects
- Stomach upset or indigestion
- Nausea or vomiting
- Diarrhea or constipation
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers.
- Heart attack or stroke, especially in individuals with pre-existing cardiovascular conditions or prolonged use.
- Kidney problems, including worsening kidney function.
- Liver damage, indicated by yellowing of the skin or eyes (jaundice), dark urine, or severe fatigue.
Risks and Warnings of Mobic
- Cardiovascular Risks: Mobic, like other NSAIDs, can increase the risk of heart attack or stroke, especially in individuals with pre-existing heart disease or when used long-term. Patients should be monitored for signs of cardiovascular issues.
- Gastrointestinal Risks: Mobic may cause stomach ulcers, bleeding, or perforation of the stomach or intestines, which can be fatal. This risk is higher in elderly patients and those with a history of GI issues.
- Renal and Hepatic Risks: Mobic can lead to kidney damage or worsen pre-existing kidney conditions. It may also cause liver dysfunction or damage, particularly in patients with pre-existing liver disease.
- Pregnancy Warning: Mobic should not be used during the third trimester of pregnancy, as it may cause harm to the fetus, including premature closure of the ductus arteriosus.
Interactions with Mobic
Common Drug Interactions
- Anticoagulants (e.g., warfarin): Taking Mobic with blood thinners can increase the risk of bleeding.
- Other NSAIDs or aspirin: Concurrent use increases the risk of gastrointestinal side effects.
- Diuretics: NSAIDs like Mobic may reduce the effectiveness of diuretics and increase the risk of kidney problems.
- ACE inhibitors or angiotensin II receptor blockers (ARBs): These medications, when combined with NSAIDs, may worsen kidney function and reduce blood pressure control.
Alternatives to Mobic
- Celebrex (celecoxib): A selective COX-2 inhibitor that is used to treat similar inflammatory conditions with a potentially lower risk of gastrointestinal side effects.
- Ibuprofen (Advil, Motrin): Another NSAID commonly used for pain and inflammation.
- Naproxen (Aleve): An over-the-counter NSAID used to treat pain and inflammation.
- Methotrexate: A disease-modifying antirheumatic drug (DMARD) often used to treat rheumatoid arthritis.
- Acetaminophen (Tylenol): An alternative for pain relief that does not have the anti-inflammatory properties of NSAIDs but is less likely to cause stomach problems.
