Browse Medications by Drug Class: Opioid Agonist/Antagonists

Moderate to Severe Pain

Opioid agonist/antagonists, such as buprenorphine or nalbuphine, are effective in managing moderate to severe pain, especially in settings where the risk of opioid misuse needs to be minimized. Their partial agonist activity provides sufficient pain relief while reducing the risks of euphoria and dependency, making them suitable for post-operative or injury-related pain.

Chronic Pain

For patients with chronic pain conditions, such as cancer pain or fibromyalgia, opioid agonist/antagonists provide sustained relief while limiting tolerance and dependency risks. Long-acting formulations, like transdermal buprenorphine patches, offer consistent symptom control with fewer side effects compared to traditional opioids.

Opioid Use Disorder (OUD)

Buprenorphine is a cornerstone therapy for OUD, reducing withdrawal symptoms and cravings without producing the euphoric effects of full opioid agonists. It helps patients stabilize during recovery and is often used in medication-assisted treatment (MAT) programs to support long-term sobriety.

Anesthesia and Sedation

Opioid agonist/antagonists are used in anesthesia protocols to provide pain relief and sedation during surgical procedures. Medications like nalbuphine are particularly valuable in this setting due to their balanced effects and reduced risk of respiratory depression.

Adults

Adults experiencing moderate to severe pain that requires opioid-level treatment but are at risk of misuse or dependency benefit from opioid agonist/antagonists. These medications offer effective pain relief with a reduced likelihood of addiction, making them ideal for individuals recovering from surgery or managing chronic conditions.

Children

Opioid agonist/antagonists are rarely used in pediatric populations but may be considered in specific cases, such as severe post-operative pain or injury. When prescribed, these medications are carefully dosed based on the child's age and weight, ensuring safety and efficacy under close medical supervision.

Seniors

Seniors with chronic or acute pain conditions benefit from the safety profile of opioid agonist/antagonists, which limit side effects like sedation and respiratory depression. Healthcare providers carefully tailor these medications to the unique needs of older adults, considering factors like metabolism and the risk of falls.