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Bunavail
Bunavail (Buprenorphine and naloxone) is a buccal film used for the treatment of opioid dependence. Buprenorphine is a partial opioid agonist, which helps to reduce withdrawal symptoms and cravings, while naloxone is an opioid antagonist that helps prevent misuse by blocking the effects of opioids if the medication is misused. Bunavail is used as part of a comprehensive treatment program, including counseling and behavioral therapy, for opioid addiction.
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Frequently Asked Questions
How long does it take for Bunavail to work?
Bunavail starts to reduce opioid withdrawal symptoms within 1 to 2 hours after taking it.
Can Bunavail be misused?
Bunavail is designed to reduce the potential for misuse. The inclusion of naloxone helps block the effects of opioids if the drug is injected.
What should I do if I miss a dose of Bunavail?
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your next dose at the scheduled time.
Can Bunavail be used during pregnancy?
Buprenorphine may be used during pregnancy if prescribed by a healthcare provider, but careful monitoring is necessary. Naloxone is generally avoided during pregnancy due to the risk of withdrawal symptoms in the fetus.
Does Bunavail interact with other medications?
Yes, Bunavail can interact with other medications, particularly those that affect the central nervous system (e.g., alcohol, benzodiazepines), increasing the risk of sedation or respiratory depression.
Comprehensive Drug Guide
How Does Bunavail Work?
Bunavail contains buprenorphine, which binds to opioid receptors in the brain, reducing withdrawal symptoms and cravings associated with opioid dependence. Naloxone is included to block the effects of opioids if the medication is misused by injection, reducing the risk of abuse.
Common Dosages
- Buccal films: 2.1 mg/0.3 mg, 4.2 mg/0.7 mg, and 6.3 mg/1 mg of buprenorphine and naloxone.
Typical Dosing
- For opioid dependence: The recommended starting dose is one buccal film, placed inside the cheek, once daily. The dose may be adjusted based on response and clinical need.
Typical Dosing
FDA Approved Indications
- Opioid dependence as part of a comprehensive treatment plan
Who Shouldn't Take Bunavail?
- Known hypersensitivity to buprenorphine, naloxone, or any component of the formulation.
- Severe liver impairment.
Advice From The Pharmacist
- Place the Bunavail buccal film inside your cheek and allow it to dissolve completely. Do not chew or swallow the film.
- Avoid eating or drinking while the film is dissolving to ensure proper absorption.
- Do not stop using Bunavail abruptly, as this may lead to withdrawal symptoms. Consult your healthcare provider to taper off the medication if necessary.
Side Effects of Bunavail
Common Side Effects
- Headache
- Nausea
- Constipation
- Drowsiness
- Sweating
Uncommon/Severe Side Effects
- Respiratory depression
- Severe allergic reactions
- Liver problems
Risks and Warnings of Bunavail
- Respiratory Depression: Bunavail can cause respiratory depression, particularly when combined with other central nervous system depressants such as alcohol, benzodiazepines, or other opioids.
- Risk of Dependence: Buprenorphine, though less likely to cause dependence compared to full opioids, can still lead to physical dependence if misused.
- Hepatitis Risk: Bunavail may cause liver injury in patients with pre-existing liver conditions.
Interactions with Bunavail
Common Drug Interactions
- Benzodiazepines: Concomitant use of Bunavail with benzodiazepines or other CNS depressants may result in profound sedation, respiratory depression, and even death.
- Alcohol: Avoid consuming alcohol while taking Bunavail, as it increases the risk of respiratory depression and liver damage.
- CYP3A4 inhibitors: Drugs that inhibit CYP3A4 enzymes (e.g., Ketoconazole) can increase Buprenorphine levels, increasing the risk of side effects.
Common Food Interactions
Alternatives to Bunavail
- Suboxone (Buprenorphine and naloxone): A similar medication used for the treatment of opioid dependence in a sublingual tablet or film form.
- Zubsolv (buprenorphine and naloxone): An alternative combination for opioid dependence treatment.
- Methadone: Another opioid agonist used in medication-assisted treatment for opioid dependence.
