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Percocet

Percocet is a combination medication that contains oxycodone and acetaminophen. It is used to relieve moderate to severe pain and is typically prescribed after surgeries, injuries, or for chronic pain conditions. Oxycodone is an opioid analgesic, while acetaminophen enhances pain relief and reduces fever.



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Frequently Asked Questions

How quickly does Percocet work?
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Patients may begin to feel pain relief within 30 to 60 minutes after taking the medication.

Can I take Percocet with food?
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Yes, Percocet can be taken with or without food, but taking it with food may help reduce gastrointestinal side effects.

What should I do if I miss a dose?
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If you miss a dose and it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up.

Is Percocet safe during pregnancy?
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Percocet should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.

What are the signs of serious side effects to watch for?
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Monitor for symptoms of severe respiratory depression, liver damage (e.g., jaundice), or allergic reactions, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Percocet Work?

  • Oxycodone: Binds to opioid receptors in the central nervous system (CNS), altering the perception of pain and emotional response to pain.
  • Acetaminophen: Works by inhibiting the synthesis of prostaglandins in the brain, which helps to alleviate pain and reduce fever.

Common Dosages

Percocet is available in various formulations, including:

  • Tablets: Common strengths include 2.5 mg, 5 mg, 7.5 mg, and 10 mg of oxycodone combined with 325 mg of acetaminophen.

Typical Dosing

  • Adults: The usual starting dose is 1 tablet every 6 hours as needed for pain. The maximum dosage should not exceed 4,000 mg of acetaminophen per day to avoid liver toxicity.

Typical Dosing

FDA Approved Indications

The relief of moderate to severe pain when treatment with an opioid is necessary.


Off-Label Uses


Who Shouldn't Take Percocet?

  • Known hypersensitivity to oxycodone, acetaminophen, or any component of the formulation
  • Severe respiratory depression
  • Acute or severe asthma
  • A history of substance use disorder


Advice From The Pharmacist

  • Take Percocet exactly as prescribed, and do not exceed the recommended dose.
  • Use caution when driving or operating heavy machinery until you know how the medication affects you.
  • Avoid alcohol and other CNS depressants while taking Percocet, as this can increase the risk of severe side effects.


Side Effects of Percocet

Common Side Effects

  • Dizziness or lightheadedness
  • Nausea or vomiting
  • Constipation
  • Drowsiness


Uncommon/Severe Side Effects

  • Respiratory depression
  • Liver damage (due to acetaminophen overdose)
  • Allergic reactions (rash, itching, swelling)


Risks and Warnings of Percocet

  • Respiratory Depression: Monitor for signs of respiratory distress, especially in patients with pre-existing respiratory conditions.
  • Dependence and Withdrawal: Caution in patients with a history of substance use disorders; discontinuation may lead to withdrawal symptoms.

Interactions with Percocet

Common Drug Interactions

  • CNS Depressants: Use with caution when combined with other medications that cause sedation, as this may enhance effects and increase the risk of respiratory depression.
  • Other Opioids: Avoid concurrent use with other opioid medications to prevent overdose.

Alternatives to Percocet

  • Other Opioid Analgesics: Such as hydrocodone or morphine for pain management.
  • Non-opioid Pain Management: Such as NSAIDs (e.g., ibuprofen or naproxen) for mild to moderate pain.