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Endocet

Endocet is a combination medication that contains oxycodone (a strong opioid pain reliever) and acetaminophen (a non-opioid pain reliever). It is used to treat moderate to severe pain when other pain treatments are not sufficient. Oxycodone works in the brain to change how your body feels and responds to pain, while acetaminophen helps reduce fever and relieve pain. Endocet is commonly prescribed for short-term use following surgery, injury, or for other painful conditions.



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Frequently Asked Questions

How long does it take for Endocet to start working?
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Endocet usually begins to relieve pain within 30 to 60 minutes after taking the dose, with peak effects occurring around 1 to 2 hours after ingestion.

Can I drive while taking Endocet?
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No, Endocet can cause drowsiness and impair your ability to operate machinery or drive safely. Avoid such activities until you know how the medication affects you.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Can I take Endocet with other over-the-counter pain medications?
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Avoid taking other medications that contain acetaminophen, as combining them can increase the risk of liver damage. Non-acetaminophen pain relievers (e.g., ibuprofen or naproxen) may be safe but consult your healthcare provider first.

Is Endocet addictive?
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Yes, Endocet contains oxycodone, an opioid that can lead to physical and psychological dependence, especially with long-term use. Follow your healthcare provider’s instructions closely and use the medication for the shortest time possible.

Comprehensive Drug Guide

How Does Endocet Work?

Oxycodone binds to opioid receptors in the brain and spinal cord, blocking pain signals and altering the perception of pain. Acetaminophen works by inhibiting the production of prostaglandins, chemicals in the brain that contribute to pain and inflammation. Together, these medications provide more effective pain relief than either drug alone.

Common Dosages

Common dosage forms of Endocet include:

  • 5 mg/325 mg tablet (oxycodone/acetaminophen)
  • 7.5 mg/325 mg tablet
  • 10 mg/325 mg tablet

Typical Dosing

  • The usual starting dose is 1 tablet every 4 to 6 hours as needed for pain. The maximum daily dose should not exceed 4000 mg of acetaminophen to prevent liver damage.
  • Doses should be adjusted based on the severity of the pain, patient response, and tolerance.


Typical Dosing

Who Shouldn't Take Endocet?

  • Severe respiratory depression
  • Acute or severe bronchial asthma in an unmonitored setting
  • Known hypersensitivity to oxycodone, acetaminophen, or any components of the formulation
  • Paralytic ileus (intestinal blockage)

Advice From The Pharmacist

  • Take Endocet exactly as prescribed. Do not take more than the prescribed dose, as this can lead to overdose or liver damage from the acetaminophen component.
  • Avoid taking other medications that contain acetaminophen (such as cold or flu remedies) while taking Endocet to avoid exceeding the recommended daily limit of acetaminophen.
  • Do not abruptly stop taking Endocet after long-term use, as this can lead to withdrawal symptoms. Discuss tapering with your healthcare provider if discontinuation is necessary.
  • Avoid alcohol and other central nervous system depressants (e.g., benzodiazepines) while taking Endocet, as this can increase the risk of severe side effects, including respiratory depression.


Side Effects of Endocet

Common Side Effects

  • Drowsiness
  • Dizziness
  • Constipation
  • Nausea
  • Vomiting
  • Lightheadedness


Uncommon/Severe Side Effects

  • Respiratory depression (slow or shallow breathing)
  • Liver toxicity (due to acetaminophen)
  • Allergic reactions (rash, itching, swelling, difficulty breathing)
  • Addiction, abuse, and misuse


Risks and Warnings of Endocet

  • Addiction, Abuse, and Misuse: Endocet contains oxycodone, an opioid, which has a high potential for abuse, dependence, and addiction. It should only be used as prescribed and for the shortest time necessary.
  • Respiratory Depression: Oxycodone can cause life-threatening respiratory depression, particularly in elderly, debilitated, or opioid-naïve patients. Use with caution, especially in patients with existing respiratory conditions.
  • Liver Toxicity: Acetaminophen can cause severe liver damage if taken in excessive doses. The daily limit of acetaminophen should not exceed 4000 mg, and patients should avoid other acetaminophen-containing medications.
  • Withdrawal Symptoms: Stopping Endocet suddenly after prolonged use can lead to withdrawal symptoms, such as restlessness, muscle pain, insomnia, and anxiety.

Interactions with Endocet

Common Drug Interactions

  • CNS depressants: Combining Endocet with alcohol, benzodiazepines, or other central nervous system depressants can increase the risk of respiratory depression, sedation, and death.
  • MAO Inhibitors: Oxycodone should not be used with monoamine oxidase inhibitors (MAOIs) as this may result in severe and unpredictable effects on the brain and nervous system.
  • Anticholinergic Drugs: These medications can increase the risk of urinary retention and severe constipation when taken with Endocet.

Alternatives to Endocet

  • Hydrocodone-Acetaminophen (Vicodin): Another opioid combination used for moderate to severe pain.
  • Tramadol: A less potent opioid used for moderate pain relief.
  • Ibuprofen (Advil): A non-opioid alternative for mild to moderate pain relief, especially when inflammation is present.
  • Gabapentin: Used for nerve pain, especially when opioids are less effective or inappropriate.